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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Artificial Intelligence Accurately Predicts Breast Cancer Years Before Diagnosis

By MedImaging International staff writers
Posted on 16 Oct 2024

Image: INSIGHT MMG software detects breast cancer with 97% accuracy (Photo courtesy of Lunit Inc.)

Mammography screening helps reduce breast cancer mortality; however, its accuracy is not perfect. For decades, various strategies have been employed to enhance the interpretive performance of mammography, including double reading. Recently, several commercial artificial intelligence (AI) algorithms have received regulatory approval as supplementary tools for radiologists, showing promising results in detecting cancer on mammograms. These AI algorithms are designed to highlight areas of concern and provide breast-level and examination-level malignant neoplasm scores to assist interpreting radiologists. However, emerging research indicates that these same AI scores may also identify imaging features linked to future breast cancer years before they are clinically diagnosed. If commercial AI algorithms developed for immediate cancer detection can also assess future cancer risk, then more accurate and reliable short-term risk estimation could facilitate personalized preventive measures (e.g., more frequent or supplemental imaging), potentially leading to earlier breast cancer detection and less aggressive treatment. Analyses of AI breast cancer detection scores from consecutive mammography screenings prior to diagnoses are essential to evaluate the potential of these tools for estimating future disease risk. A new study has now investigated whether a commercial AI algorithm for breast cancer detection could predict the development of future cancer.

This collaborative study involving researchers from the Norwegian Institute of Public Health (NIPH, Oslo, Norway) utilized AI cancer detection scores recorded during multiple consecutive screening rounds of the national screening program, BreastScreen Norway. The researchers combined consecutive AI scores with long-term cancer outcomes to determine whether Lunit Inc.’s (Seoul, South Korea) INSIGHT MMG, a regulatory-cleared commercial AI algorithm for breast cancer detection, could estimate the onset of future breast cancers identified in subsequent screening rounds. Lunit INSIGHT MMG analyzes mammography images with 97% accuracy, pinpointing lesions that are suspicious for breast cancer and providing an abnormality score reflecting the likelihood of the existence of detected lesions.

This retrospective cohort study included 116,495 women aged 50 to 69 years who had no prior history of breast cancer and underwent at least three consecutive biennial screening examinations. The researchers employed scores from INSIGHT MMG for breast cancer detection and gathered screening data from multiple consecutive rounds of mammography. The study findings, published in JAMA, indicate that INSIGHT MMG could signal breast cancer up to six years before it develops. The AI system’s discriminatory accuracy for predicting future screening-detected or interval cancer risk 4 to 6 years before diagnosis met or exceeded the performance of established risk calculators currently in widespread use. These results suggest that commercial AI algorithms could help identify women at high risk of developing future breast cancer, paving the way for personalized screening strategies to facilitate earlier diagnosis.

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87 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

91 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

92 (58.174133300781): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802779 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (125.88500976562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

94 (397.92060852051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

95 (472.06878662109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294802779 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (548.12431335449): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (370.97930908203): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

99 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

100 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

101 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

102 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

103 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

104 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

105 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

106 (328.06396484375): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 19030.094146729): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (661.84997558594): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802779 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802779 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 8129.1198730469): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (87.02278137207): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (272.03559875488): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (240.08750915527): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (185.01281738281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (206.94732666016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (277.99606323242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (108.00361633301): SELECT name FROM jos_deeppockets WHERE id=211

121 (45.7763671875): SELECT name FROM jos_deeppockets WHERE id=211

122 (521.89826965332): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (472.06878662109): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

125 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

126 (!!!!! 7273.1971740723): TRUNCATE TABLE jos_trademed_module

127 (101.08947753906): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802779 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (828.02772521973): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

131 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

132 (!!!!! 1071.9299316406): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

134 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

135 (48.87580871582): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802779 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802779 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (28.848648071289): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

137 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

138 (28.133392333984): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (!!!!! 1179.9335479736): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

140 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802779 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802779 AND published='1' LIMIT 1

141 (114.91775512695): select jos_twitters.link from jos_twitters where cat=10

142 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

143 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

144 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

145 (284.91020202637): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (898.12278747559): insert into jos_banners_delta values (14615,'2025-06-21 02:49:46','216.73.216.120','view'),(14202,'2025-06-21 02:49:46','216.73.216.120','view'),(14203,'2025-06-21 02:49:46','216.73.216.120','view')

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