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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

AI System Detects Subtle Changes in Series of Medical Images Over Time

By MedImaging International staff writers
Posted on 28 Feb 2025

Image: This image presents heatmaps highlighting the areas LILAC focuses on when making predictions (Photo courtesy of Dr. Heejong Kim/Weill Cornell Medicine)

Traditional approaches for analyzing longitudinal image datasets typically require significant customization and extensive pre-processing. For instance, in studies of the brain, researchers often begin with raw brain MRI data, focusing on a specific brain area, correcting for variations in view angles, adjusting for size discrepancies, and eliminating artifacts—before proceeding with the main analysis. Now, a new AI-driven system that can effectively detect changes in medical images over time and predict outcomes offers enhanced sensitivity and adaptability, making it applicable to a wide variety of medical and scientific contexts.

This innovative system, called LILAC (Learning-based Inference of Longitudinal imAge Changes), leverages machine learning techniques and was developed by researchers at Weill Cornell Medicine (New York City, NY, USA). In a study published in the Proceedings of the National Academy of Sciences, the team demonstrated how LILAC could analyze diverse time-series images, or longitudinal data, which included developing IVF embryos, healing tissues after injuries, and aging brains. The researchers found that LILAC can detect even minute differences between images taken over time and predict related outcomes, such as cognitive scores from brain scans. The system is designed to work with much greater flexibility by automatically handling corrections and identifying key changes.

In a proof-of-concept experiment, the researchers trained LILAC on hundreds of image sequences from in-vitro fertilized embryos as they developed. The system was then tested on new sequences to determine which image in each pair was taken first—a task that is difficult to perform without a clear time-related signal in the images. LILAC accurately completed this task with around 99% accuracy, with only a few errors in image pairs with short time intervals. Additionally, LILAC proved highly effective in ordering images of healing tissue from the same sequences and detecting group-level differences in healing rates between untreated tissue and tissue that had undergone an experimental treatment.

Similarly, LILAC was able to predict time intervals between MRI scans of healthy older adults' brains, as well as estimate individual cognitive scores from MRIs of patients with mild cognitive impairment, performing with much less error compared to conventional methods. In all these cases, the researchers showed that LILAC could be easily adapted to emphasize the most relevant image features for detecting changes in individual subjects or distinguishing between groups, potentially offering new clinical and scientific insights. The next phase of research will involve testing LILAC in real-world settings, such as predicting treatment responses from MRI scans of prostate cancer patients.

“This new tool will allow us to detect and quantify clinically relevant changes over time in ways that weren't possible before, and its flexibility means that it can be applied off-the-shelf to virtually any longitudinal imaging dataset,” said study senior author Dr. Mert Sabuncu. “We expect this tool to be useful especially in cases where we lack knowledge about the process being studied, and where there is a lot of variability across individuals.”

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82 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (!!!!! 5033.9698791504): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

91 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

92 (69.141387939453): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804193 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

94 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

95 (336.1701965332): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804193 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (!!!!! 2098.0834960938): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (366.2109375): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

99 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

100 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

101 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

102 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

103 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

104 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

105 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

106 (319.9577331543): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 20579.099655151): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (492.09594726562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804193 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804193 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (66.041946411133): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (35.04753112793): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (500.20217895508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=215

121 (27.894973754883): SELECT name FROM jos_deeppockets WHERE id=215

122 (557.89947509766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (566.95938110352): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

125 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

126 (!!!!! 9818.0770874023): TRUNCATE TABLE jos_trademed_module

127 (143.05114746094): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804193 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (630.85556030273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

131 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

132 (!!!!! 1525.1636505127): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

134 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

135 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804193 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804193 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

137 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

138 (31.948089599609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

140 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804193 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804193 AND published='1' LIMIT 1

141 (36.001205444336): select jos_twitters.link from jos_twitters where cat=10

142 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

143 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

144 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

145 (277.99606323242): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

146 (!!!!! 1193.0465698242): insert into jos_banners_delta values (14202,'2025-06-21 01:02:48','216.73.216.120','view'),(14203,'2025-06-21 01:02:48','216.73.216.120','view')

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