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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Novel Radiotracer Identifies Biomarker for Triple-Negative Breast Cancer

By MedImaging International staff writers
Posted on 13 Mar 2025

Image: 68Ga-FZ-NR-1 PET/CT images and 18F-FDG PET/CT and PET/MR images in representative Nectin-4–positive TNBC patients (Photo courtesy of The Journal of Nuclear Medicine)

Triple-negative breast cancer (TNBC), which represents 15-20% of all breast cancer cases, is one of the most aggressive subtypes, with a five-year survival rate of about 40%. Due to its significant heterogeneity and high recurrence rate, treatment can be particularly challenging. However, recent research has introduced a novel PET radiotracer that can effectively visualize Nectin-4, a promising biomarker associated with TNBC. Published in The Journal of Nuclear Medicine, the study suggests that this new PET tracer could play a pivotal role in diagnosing, treating, and monitoring this aggressive form of cancer, potentially improving clinical outcomes for patients.

Nectin-4 is a biomarker that is highly expressed in TNBC, but effective imaging tools targeting this marker have been lacking until now. To address this critical need, scientists at the Fudan University Shanghai Cancer Center (Shanghai, China) developed a series of Nectin-4-targeted radiotracers and tested their efficacy in detecting Nectin-4 in TNBC. The researchers created three different radiotracers—68Ga-FZ-NR-1, 68Ga-FZ-NR-2, and 68Ga-FZ-NR-3—and assessed their targeting ability and specificity both in vitro and in vivo, including in a murine tumor model.

After conducting preclinical experiments and screenings, the 68Ga-FZ-NR-1 radiotracer demonstrated the highest targeting efficacy and was selected for further evaluation in a first-in-human study. PET/CT scans using 68Ga-FZ-NR-1 were performed on nine TNBC patients. Positive lesions were biopsied and analyzed using immunohistochemistry to assess Nectin-4 expression levels. The PET/CT imaging with 68Ga-FZ-NR-1 effectively identified tumors in these patients, which was later confirmed by 18F-FDG PET/CT. Biopsy results revealed that the areas identified as positive by 68Ga-FZ-NR-1 PET/CT had high Nectin-4 expression, confirming the tracer’s ability to specifically target and detect Nectin-4 in TNBC tumors.

“The significance of this research lies in its potential to revolutionize the diagnostic landscape for TNBC patients,” said Shaoli Song, PhD, director of nuclear medicine in the Department of Nuclear Medicine at the Fudan University Shanghai Cancer Center. “With the introduction of 68Ga-FZ-NR-1, we are now able to detect tumors with greater precision and provide patients with more reliable diagnostic information. This advancement has the potential to improve treatment outcomes by enabling more accurate disease assessment and personalized therapeutic strategies. We anticipate that this work will stimulate further research into the development and clinical application of Nectin-4-targeted imaging agents. Ultimately, this could enhance the diagnostic value of nuclear medicine not only for TNBC, but also for other cancers.”

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83 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (105.14259338379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

91 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

92 (84.161758422852): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804331 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

94 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

95 (448.94218444824): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804331 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (!!!!! 1055.9558868408): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (!!!!! 1110.0769042969): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (272.98927307129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

99 (225.06713867188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

100 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

101 (154.01840209961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

102 (!!!!! 1034.9750518799): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

103 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

104 (823.974609375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

105 (677.10876464844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

106 (452.04162597656): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 101971.86470032): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (664.94941711426): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804331 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804331 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 33828.020095825): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (!!!!! 1528.9783477783): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (!!!!! 3076.7917633057): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (936.98501586914): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (!!!!! 3813.0283355713): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (361.20414733887): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (516.89147949219): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (304.9373626709): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (216.96090698242): SELECT name FROM jos_deeppockets WHERE id=213

121 (43.153762817383): SELECT name FROM jos_deeppockets WHERE id=213

122 (696.18225097656): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (863.07525634766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (641.1075592041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

125 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

126 (!!!!! 8198.9765167236): TRUNCATE TABLE jos_trademed_module

127 (145.91217041016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804331 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (369.07196044922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (204.08630371094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (141.14379882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

131 (377.89344787598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

132 (!!!!! 5008.9359283447): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

134 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

135 (51.021575927734): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804331 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804331 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (38.14697265625): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

137 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

138 (51.021575927734): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (124.21607971191): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

140 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804331 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804331 AND published='1' LIMIT 1

141 (48.87580871582): select jos_twitters.link from jos_twitters where cat=10

142 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

143 (32.186508178711): select jos_google_plus.link from jos_google_plus where cat=10

144 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

145 (359.05838012695): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 2100.944519043): insert into jos_banners_delta values (14615,'2025-06-21 01:00:23','216.73.216.120','view'),(14202,'2025-06-21 01:00:23','216.73.216.120','view'),(14203,'2025-06-21 01:00:23','216.73.216.120','view')

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