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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Ultra-Low Dose CT Aids Pneumonia Diagnosis in Immunocompromised Patients

By MedImaging International staff writers
Posted on 17 Mar 2025

Image: Axial noncontrast chest CT lung window images of three different sample patches shown in each row (Photo courtesy of Radiology: Cardiothoracic Imaging)

Lung infections can be life-threatening for patients with weakened immune systems, making timely diagnosis crucial. While CT scans are considered the gold standard for detecting pneumonia, repeated scans can expose patients to harmful levels of radiation. Early diagnosis is particularly important for immunocompromised patients, but the cumulative risk of radiation exposure from frequent CT scans raises concerns. Ultra-low dose CT scans, which reduce radiation exposure, often suffer from poor image quality due to added “noise,” leading to grainy textures that can hinder accurate diagnosis. A new study, published in Radiology: Cardiothoracic Imaging, reveals that denoised ultra-low dose CT scans can diagnose pneumonia in immunocompromised patients effectively, using only 2% of the radiation dose of standard CT scans.

The research, conducted by scientists at Sheba Medical Center (Ramat Gan, Israel), aimed to evaluate the denoising capabilities of a deep learning algorithm on ultra-low dose CT scans. Between September 2020 and December 2022, 54 immunocompromised patients with fevers underwent two chest CT scans: one with a standard dose and another with an ultra-low dose. The ultra-low dose CT scans were processed using a deep learning algorithm designed to reduce noise. Radiologists then assessed the scans independently, noting their findings from the standard, ultra-low dose, and denoised ultra-low dose CT images, without being aware of the patients’ clinical details.

The deep learning algorithm significantly enhanced the image quality of the ultra-low dose CT scans, improving clarity and reducing false positives. Nodules were also more easily detectable on the denoised scans. Importantly, the effective radiation dose from the ultra-low dose scans was only 2% of the standard CT scan’s radiation dose. The researchers suggest that this deep learning-based denoising method could benefit other patient groups, including pediatric patients. They plan to conduct future studies with larger sample sizes to further validate the promising results of this approach.

“This study paves the way for safer, AI-driven imaging that reduces radiation exposure while preserving diagnostic accuracy,” said lead study author Maximiliano Klug, M.D. “This pilot study identified infection with a fraction of the radiation dose. “This approach could drive larger studies and ultimately reshape clinical guidelines, making denoised ultra-low dose CT the new standard for young immunocompromised patients.”

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86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

91 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

92 (49.829483032227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804347 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

94 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

95 (352.85949707031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804347 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (576.01928710938): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (370.97930908203): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

99 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

100 (50.783157348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

101 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

102 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

103 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

104 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

105 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

106 (249.86267089844): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 27333.02116394): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (!!!!! 1224.0409851074): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804347 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804347 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 15571.117401123): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (128.98445129395): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (!!!!! 5679.8458099365): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (922.20306396484): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (643.01490783691): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (483.98971557617): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (!!!!! 2321.0048675537): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (285.14862060547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (246.04797363281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (216.00723266602): SELECT name FROM jos_deeppockets WHERE id=215

121 (591.03965759277): SELECT name FROM jos_deeppockets WHERE id=215

122 (567.91305541992): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (496.86431884766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (!!!!! 1084.0892791748): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

125 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

126 (!!!!! 3679.9907684326): TRUNCATE TABLE jos_trademed_module

127 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804347 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (342.13066101074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

131 (170.94612121582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

132 (!!!!! 1061.2010955811): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

134 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

135 (147.10426330566): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804347 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804347 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (216.00723266602): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

137 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

138 (298.97689819336): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (575.06561279297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

140 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804347 AND published='1' LIMIT 1

141 (96.08268737793): select jos_twitters.link from jos_twitters where cat=10

142 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

143 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

144 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

145 (229.83551025391): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

146 (970.84045410156): insert into jos_banners_delta values (14202,'2025-06-21 01:40:54','216.73.216.120','view'),(14203,'2025-06-21 01:40:54','216.73.216.120','view')

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