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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Advanced 3D Mammography Detects More Breast Cancers

By MedImaging International staff writers
Posted on 18 Sep 2024

Image: DBT helped to increase breast cancer detection rate and depicted invasive cancers with a lower rate of advanced cancers compared with DM (Photo courtesy of Radiology; doi.org/10.1148/radiol.232841)

Mammography is widely regarded as the gold standard for breast cancer screening in the general population. However, conventional 2D mammography, which involves taking low-dose X-ray images of the breast from two angles, misses about 20% of breast cancers. It is also linked to false-positive results, where an abnormality seen on a screening mammogram is later found not to be cancer after further tests. Digital breast tomosynthesis (DBT), an advanced form of mammography, creates 3D images of the breast by reconstructing pictures taken from different angles. Studies have shown that DBT has a higher cancer detection rate compared to standard digital mammography. Now, a new 10-year study has revealed that screening with DBT increases cancer detection rates and significantly reduces the occurrence of advanced cancers compared to conventional 2D digital mammography. The findings also suggest that 3D mammograms may lower the incidence of advanced cancer diagnoses.

In this retrospective study, researchers at Yale Cancer Center (New Haven, CT, USA) analyzed breast cancer cases detected by screening mammography over 13 years at Yale University/Yale-New Haven Health. The data included 10 years of DBT screenings, which became the standard at Yale facilities starting in 2011, and the prior three years of digital mammography screenings. The study involved 272,938 screening mammograms, with 35,544 performed using digital mammography and 237,394 using DBT. Published in the journal Radiology, the results showed that a total of 1,407 cancers were detected: 142 by digital mammography and 1,265 by DBT.

Both digital mammography and DBT detected various tumor subtypes and grades at similar rates, and the ratio of invasive cancers to ductal carcinoma in situ (DCIS) was comparable between the two methods. However, while both screening methods identified the same types of cancers, DBT detected more aggressive cancers at an earlier stage compared to digital mammography. The study found that DBT had a higher cancer detection rate (5.3% versus 4.0%) and a lower rate of advanced cancers (32.7% versus 43.6%), suggesting that earlier detection is more likely with DBT. Cancer detection improved when women underwent repeat screenings with DBT. Most true-positive cancer cases detected by DBT appeared as masses, with fewer presenting as calcifications or asymmetries. Additionally, the recall rate for DBT (7.2%) was significantly lower than that for digital mammography (10.6%). The researchers believe that further studies using long-term data are needed to better understand the full impact of DBT on screening outcomes.

"DBT's lower recall rate, higher cancer detection rate and lower rate of advanced cancers is a win, win, win," said co-first author Dr. Liane Philpotts, a professor of radiology and biomedical imaging at Yale School of Medicine (YSM) and a member of Yale Cancer Center. "These findings add to the growing literature regarding cancer detection with DBT and support its use in screening mammography in the United States and globally. Our results may provide healthcare institutions that have not yet switched from digital mammography to DBT with the data they need to adopt the newer technology."

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81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (!!!!! 1022.1004486084): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (146.86584472656): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (128.03077697754): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (396.0132598877): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (!!!!! 1469.8505401611): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

91 (!!!!! 2630.9490203857): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

92 (64.849853515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802493 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (!!!!! 4897.8328704834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

94 (!!!!! 6704.8072814941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

95 (!!!!! 1811.9812011719): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294802493 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (!!!!! 2351.9992828369): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (974.89356994629): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (270.12825012207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

99 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

100 (363.11149597168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

101 (546.93222045898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

102 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

103 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

104 (318.05038452148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

105 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

106 (148.05793762207): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 36702.871322632): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (!!!!! 6110.9066009521): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802493 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802493 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 23297.071456909): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (589.84756469727): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (513.07678222656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (!!!!! 2478.1227111816): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (911.95106506348): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (283.00285339355): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (359.05838012695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (394.10591125488): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (!!!!! 1523.0178833008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (465.15464782715): SELECT name FROM jos_deeppockets WHERE id=211

121 (44.822692871094): SELECT name FROM jos_deeppockets WHERE id=211

122 (!!!!! 1392.8413391113): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (938.89236450195): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (856.87637329102): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

125 (283.00285339355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

126 (!!!!! 2881.0501098633): TRUNCATE TABLE jos_trademed_module

127 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802493 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (465.15464782715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

131 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

132 (!!!!! 1046.895980835): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (55.789947509766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

134 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

135 (90.837478637695): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802493 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802493 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

137 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

138 (28.848648071289): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (!!!!! 1662.9695892334): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

140 (!!!!! 2138.8530731201): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802493 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802493 AND published='1' LIMIT 1

141 (104.90417480469): select jos_twitters.link from jos_twitters where cat=10

142 (26.941299438477): select jos_facebook.link from jos_facebook where cat=10

143 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

144 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

145 (287.05596923828): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 6281.1374664307): insert into jos_banners_delta values (14615,'2025-06-21 04:03:32','216.73.216.120','view'),(14202,'2025-06-21 04:03:32','216.73.216.120','view'),(14203,'2025-06-21 04:03:32','216.73.216.120','view')

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