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Novel Imaging Method Enables Early Diagnosis and Treatment Monitoring of Type 2 Diabetes

By MedImaging International staff writers
Posted on 16 Apr 2025

Image: Diagram of ULM processing (Photo courtesy of Cyborg and Bionic Systems)

Type 2 diabetes is recognized as an autoimmune inflammatory disease, where chronic inflammation leads to alterations in pancreatic islet microvasculature, a key factor in β-cell dysfunction. The pancreas is richly vascularized, and understanding changes in islet blood flow is essential for comprehending the progression of diabetes and the functionality of β-cells. Current imaging methods like functional MRI and Doppler ultrasound have limitations in their resolution and sensitivity to microvascular details, which hampers the ability to detect early-stage changes in islet function and β-cell mass. Now, a new study has demonstrated the use of Ultrasound Localization Microscopy (ULM) for monitoring the progression of Type 2 Diabetes and assessing the effectiveness of anti-cytokine immunotherapy. This research, published in Cyborg and Bionic Systems, utilized ULM imaging to examine pancreatic microvasculature in vivo, offering valuable insights into alterations in β-cell mass and islet function during the course of Type 2 Diabetes.

In this study, researchers from The Second Affiliated Hospital of Zhejiang University School of Medicine (SAHZU, Hangzhou, China) employed a rat model of Type 2 Diabetes induced by a high-fat diet and streptozotocin injection. They explored the application of ULM to monitor changes in pancreatic microvasculature and β-cell function. By combining ULM imaging with contrast-enhanced ultrasound, the researchers achieved high-resolution visualization of microvascular structure and blood flow dynamics. They tracked the movement of microbubbles and quantified vascular parameters such as tortuosity, fractal dimension, and vessel density to evaluate disease progression. Furthermore, they tested the impact of anti-cytokine immunotherapy (XOMA052) on β-cell function by assessing its ability to restore the microvascular environment. Their findings revealed significant improvements in vascular structure and function, suggesting that the therapy had a positive effect on β-cell function. The study concluded that ULM is a promising non-invasive tool for monitoring Type 2 Diabetes progression and evaluating the efficacy of therapeutic treatments like anti-cytokine therapy.

The study provides strong evidence that ULM can be used as an effective non-invasive method to track the progression of Type 2 Diabetes and assess the impact of anti-cytokine immunotherapy. ULM enabled high-resolution imaging of pancreatic microvascular morphology and hemodynamics, which were closely linked to β-cell loss and islet dysfunction. The treatment with XOMA052, an anti-cytokine therapy, notably enhanced microvascular structure and function, indicating its potential to restore β-cell function. However, the researchers also noted some limitations. The resolution of ULM could be influenced by the ultrasound system's frame rate, potentially affecting the precision of blood flow measurements. Additionally, motion artifacts and signal interference from surrounding tissues may impact image reconstruction and the accuracy of quantification.

“As a novel imaging method. ULM offers high resolution and allows for real-time, in vivo monitoring of pancreatic microvascular morphology and hemodynamics,” said study author Tao Zhang, PhD at The Second Affiliated Hospital of Zhejiang University School of Medicine. “ULM overcomes the limitations of traditional imaging methods and provides a new opportunity for early diagnosis and treatment monitoring of Type 2 Diabetes.”

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79 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (75.817108154297): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (!!!!! 2676.9638061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

91 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

92 (68.902969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804668 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (!!!!! 2054.9297332764): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

94 (130.89179992676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

95 (570.05882263184): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804668 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (625.1335144043): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (391.00646972656): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (!!!!! 1191.1392211914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

99 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

100 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

101 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

102 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

103 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

104 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

105 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

106 (376.93977355957): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 53872.108459473): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (581.97975158691): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804668 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804668 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 14748.096466064): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (65.803527832031): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (336.88545227051): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (234.84230041504): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (289.9169921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (204.08630371094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (344.99168395996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (205.03997802734): SELECT name FROM jos_deeppockets WHERE id=214

121 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=214

122 (684.02290344238): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (!!!!! 1478.1951904297): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

125 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

126 (!!!!! 17366.886138916): TRUNCATE TABLE jos_trademed_module

127 (616.07360839844): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804668 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (389.09912109375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

131 (50.783157348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

132 (!!!!! 3182.8880310059): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (57.220458984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

134 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

135 (49.114227294922): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804668 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804668 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

137 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

138 (33.140182495117): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

140 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804668 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804668 AND published='1' LIMIT 1

141 (57.93571472168): select jos_twitters.link from jos_twitters where cat=10

142 (33.140182495117): select jos_facebook.link from jos_facebook where cat=10

143 (32.186508178711): select jos_google_plus.link from jos_google_plus where cat=10

144 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

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