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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

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Smart Ultrasound-Activated Immune Cells Destroy Cancer Cells for Extended Periods

By MedImaging International staff writers
Posted on 04 Apr 2025

Image: The new type of Sonogenetic EchoBack-CAR T cell (Photo courtesy of Longwei Liu/USC)

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a highly promising cancer treatment, especially for bloodborne cancers like leukemia. This highly personalized therapy involves extracting T-cells from a patient’s blood, modifying them genetically to improve their ability to identify and destroy cancer cells. Researchers have now taken a significant step forward by developing a new form of CAR T-cell therapy called the “EchoBack CAR T-cell,” a technology that could revolutionize cancer immunotherapy by targeting stubborn solid tumors. This innovation, detailed in the scientific journal Cell, offers a new approach to overcoming key challenges in treating tumors that are typically resistant to immunotherapy while protecting healthy tissue.

Biomedical engineers from the Viterbi School of Engineering at the University of Southern California (Los Angeles, CA, USA) have demonstrated that the EchoBack-CAR T-cells can remain active in attacking tumor cells for five times longer than traditional CAR T-cells, making them highly effective for extended periods. The technology is ready for medical applications and can be controlled remotely to target tumors with focused ultrasound, enhancing both the safety and efficacy of treatments. In comparison to first-generation ultrasound-controllable CAR T-cells, which typically attack cancer cells for only up to 24 hours before depleting, the EchoBack-CAR T-cells can target and destroy cancer cells for at least five days without tiring. The team’s focused ultrasound technology acts as an “on switch” for the CAR T-cells, triggering them with a brief, 10-minute pulse of ultrasound, which activates the cells to detect and target cancer cells nearby.

The name “EchoBack-CAR” stems from the cells' unique mechanisms that mimic the ultrasound stimulation used to activate them. These cells have a feedback system, referred to as the “back” in EchoBack, which allows them to respond to tumor cells and activate themselves to initiate the attack. In laboratory experiments using mouse models, the team tested these enhanced CAR T-cells against various tumor types, including prostate cancer and glioblastoma. The results were compelling, with the ultrasound-controlled CAR T-cells outperforming the standard CAR T-cells, even after being repeatedly exposed to tumor cells. While the traditional CAR T-cells became exhausted and dysfunctional, the new EchoBack-CAR T-cells continued to function optimally, killing cancer cells more effectively.

This breakthrough offers new potential for more powerful, precise, and patient-friendly cancer treatments. The research team believes that the EchoBack CAR T-cells are not just a theoretical concept but a tangible step toward safer and more efficient immunotherapy, giving hope to patients with hard-to-treat tumors. The team is optimistic that this new technology can be adapted as a modular tool for targeting other solid tumors, such as breast cancer and retinoblastoma, expanding the possibilities of immunotherapy for a broader range of cancer patients.

“The most exciting part is that the CAR T-cells are smart. They can listen to the ultrasound and sense the tumor cells. These types of CAR T-cells have never been developed previously, and we are looking forward to its benefits for patients in the future,” said lead author Longwei Liu, an assistant professor at the USC Viterbi School of Engineering.

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78 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

91 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

92 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804534 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

94 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

95 (430.10711669922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804534 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (786.06605529785): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (476.12190246582): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

99 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

100 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

101 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

102 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

103 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

104 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

105 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

106 (220.06034851074): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 27338.027954102): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (600.09956359863): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804534 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804534 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 9449.0051269531): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (113.96408081055): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (269.88983154297): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (74.148178100586): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (192.88063049316): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (163.07830810547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (155.92575073242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (55.789947509766): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (263.92936706543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (116.10984802246): SELECT name FROM jos_deeppockets WHERE id=214

121 (58.174133300781): SELECT name FROM jos_deeppockets WHERE id=214

122 (578.88031005859): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (621.08039855957): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

125 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

126 (!!!!! 11491.060256958): TRUNCATE TABLE jos_trademed_module

127 (430.82237243652): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804534 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (787.97340393066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (!!!!! 1037.1208190918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (!!!!! 2222.0611572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

131 (95.844268798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

132 (!!!!! 1483.9172363281): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

134 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

135 (79.154968261719): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804534 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804534 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (56.028366088867): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

137 (36.954879760742): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

138 (44.107437133789): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (137.8059387207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

140 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804534 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804534 AND published='1' LIMIT 1

141 (137.8059387207): select jos_twitters.link from jos_twitters where cat=10

142 (37.908554077148): select jos_facebook.link from jos_facebook where cat=10

143 (36.954879760742): select jos_google_plus.link from jos_google_plus where cat=10

144 (34.093856811523): select jos_linkedin.link from jos_linkedin where cat=10

145 (298.97689819336): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

146 (!!!!! 4842.0429229736): insert into jos_banners_delta values (14202,'2025-06-21 00:36:22','216.73.216.120','view'),(14203,'2025-06-21 00:36:22','216.73.216.120','view')

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