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By MedImaging International staff writers Posted on 12 May 2021
Image: Clinical workflow for integrating personalized radioprotectant devices in RT (Photo courtesy of BWH)
3D-printed devices derived from CT images can shield healthy structures in the gastrointestinal (GI) tract during radiation therapy (RT) procedures, according to a new study.
Developed at Brigham and Women's Hospital (BWH; Boston, AM, USA), the Massachusetts Institute of Technology (MIT; Cambridge, MA, USA), Massachusetts General Hospital (MGH; Boston, USA), and other institutions, the personalized shields were designed and contoured on diagnostic CT scans using the open-source 3D Slicer software app. The contours were then generated into 3D models, and the personalized radioprotective shields were 3D-printed with high atomic number materials to block gamma and x-rays and reduce radiation backscatter.
In initial testing on rats and pigs, the researchers found that the devices could protect healthy tissue in the mouth and rectum in rats and were feasible and reproducible in pigs. In human simulation studies, dosimetric modeling showed a 30% dose reduction to the normal buccal mucosa in maxillofacial cancer patients, and a 15.2% dose reduction in the rectum for prostate cancer patients. They also suggest that the new shields are more cost-effective than a hydrogel rectal spacer. The study was published on April 27, 2021, in Advanced Science.
“Personalized 3D‐printed radioprotectant devices may have great potential to reduce radiation toxicity in clinical settings where radiation is used, including neoadjuvant and adjuvant therapy, curative treatment, and palliative treatments,” concluded lead author James Byrne, PhD, of BWH, and colleagues. “This personalized approach could be applicable to a variety of cancers that respond to radiation therapy, including head and neck, lung, prostate, anal, skin, and gynecological cancers, sarcomas, and lymphomas.”
Most cancer patients undergoing RT will develop colateral tissue injury as a result of treatment. The toxicities are dependent upon the location of treatment, with the most common toxicities involving the oral cavity and gastrointestinal (GI) tract in the forms of oral mucositis, esophagitis, and proctitis. This injury may lead to severe morbidity and, ultimately, treatment breaks or discontinuation that adversely impact tumor cure rates.
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AND id != 294743304
AND id != 294743305
AND id != 294743306
AND id != 294743307
AND id != 294743308
AND id != 294743309
AND id != 294743310
AND metakey != 'aacc'
ORDER BY `ordering`90
(55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 191
(30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 192
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 193
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 194
(33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 195
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 196
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 197
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 198
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 199
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1100
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1101
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1102
(25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1103
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1104
(87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1105
(58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1106
(53.167343139648): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294788235
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1107
(45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294788235
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1108
(72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1109
(43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1110
(48.87580871582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294788235
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1111
(449.18060302734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294788235
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1112
(607.96737670898): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1113
(391.00646972656): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1114
(82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1115
(57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1116
(112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1117
(81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1118
(74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1119
(58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1120
(256.77680969238): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`121
(!!!!! 18740.892410278): SELECT
*
FROM
jos_deeppockets
WHERE
jos_deeppockets.cat = 10
AND
jos_deeppockets.type = 'deeppockets_item'
AND
jos_deeppockets.published = 1
AND
jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
ORDER BY
jos_deeppockets.hits DESC
LIMIT
7122
(87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1123
(46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1124
(447.03483581543): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294788235 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294788235 AND type='deeppockets_item' AND published='1' LIMIT 1125
(!!!!! 428810.83488464): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3126
(69.141387939453): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3127
(36.954879760742): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800513
LIMIT 1128
(29.802322387695): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800513
LIMIT 1129
(39.100646972656): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800359
LIMIT 1130
(29.087066650391): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800359
LIMIT 1131
(29.087066650391): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800361
LIMIT 1132
(27.894973754883): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800361
LIMIT 1133
(452.04162597656): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294788235
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1134
(374.07875061035): SELECT *
FROM jos_deeppockets_archive
WHERE 1=1
AND id=294788235
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1135
(195.98007202148): SELECT name FROM jos_deeppockets WHERE id=211136
(44.822692871094): SELECT name FROM jos_deeppockets WHERE id=211137
(499.01008605957): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3138
(366.9261932373): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3139
(70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1140
(49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1141
(!!!!! 33394.09828186): TRUNCATE TABLE jos_trademed_module142
(164.98565673828): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294788235
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1143
(101.08947753906): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294788235
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1144
(416.04042053223): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294788235
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1145
(178.09867858887): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294788235
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1146
(81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1147
(53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1148
(!!!!! 1157.9990386963): SELECT jos_item.*
FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
WHERE 1=1
AND (jos_item.imgMini<>'')
AND jos_item.type='L'
AND jos_item.numberID= (
SELECT jos_number.id
FROM jos_number
WHERE jos_number.journalID IN (10)
and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
LIMIT 0,1
)
ORDER BY RAND() DESC LIMIT 6149
(56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1150
(47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1151
(41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294788235 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294788235 AND type='deeppockets_item' AND published='1' LIMIT 1152
(41.007995605469): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=211 or channel_id is null)153
(42.200088500977): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=211 or channel_id is null)154
(37.908554077148): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1155
(76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1156
(60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788235 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788235 AND published='1'
LIMIT 1157
(35.04753112793): select jos_twitters.link from jos_twitters where cat=10158
(30.994415283203): select jos_facebook.link from jos_facebook where cat=10159
(31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10160
(41.007995605469): select jos_linkedin.link from jos_linkedin where cat=10161
(283.00285339355): update jos_bannersmanager_banner
set impmade=impmade+1
where id in(14615,14202,14203)162
(!!!!! 2928.0185699463): insert into jos_banners_delta values (14615,'2025-05-10 09:28:55','3.142.12.65','view'),(14202,'2025-05-10 09:28:55','3.142.12.65','view'),(14203,'2025-05-10 09:28:55','3.142.12.65','view')
Expo
.jpg "Image: CT coronary angiography for diagnosing coronary artery disease offers advantages over other diagnostic tests (Photo courtesy of 123RF)")
.jpg "Image: Exemplary illustration of the labeling and segmentation process (Photo courtesy of TUM)")
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