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X-Ray Elastography Images Soft-Tissue Tumors

By MedImaging International staff writers
Posted on 16 Apr 2020

Image: X-ray elastography images showing the stiffness of different materials (Photo courtesy of Wataru Yashiro/ Tohoku University)

A new study suggests that elastography can be adapted to X-ray imaging of soft tissues to reveal tumors earlier than other techniques.

Developed by researchers at Tohoku University (Japan), the Institute of Materials Structure Science (IMSS-KEK; Ibaraki, Japan), and other institutions, dynamic X-ray elastography is a novel imaging modality that relies on shear-wave propagation to map elastic modulus in soft viscoelastic materials, which has far only been possible via magnetic resonance imaging (MRI) and ultrasound imaging. However, X-rays can provide a thousand-fold greater resolution than ultrasound.

For the study, the researchers pneumatically vibrated polyacrylamide gel phantoms to obtain two-dimensional (2D) maps of storage and loss moduli, which were determined from the temporal variation in displacement vectors of the vibrating particles in the phantom models. The results revealed a storage moduli precision of 30% and a spatial resolution several orders of magnitude higher than that of MRI or ultrasound imaging modalities. The study was published in the April 2020 issue of Applied Physics Express.

“The resulting images would be much higher resolution, able to spot things on the scale of microns instead of millimeters,” said senior author Wataru Yashiro, PhD, of Tohoku University. “This greater precision doesn't just mean identification of much smaller or deeper lesions, but, importantly for patients, because smaller lesions can be newer ones, potentially also much earlier on in a disease or condition.”

Elastography is a medical imaging modality that maps the elastic properties and stiffness of soft tissues in order to provide diagnostic information. The technique works by creating a distortion in the tissue, observing the tissue response to infer the mechanical properties of the tissue, and then display the results as an image. The most prominent techniques use ultrasound or MRI to make both the stiffness map and an anatomical image for comparison.

Related Links:
Tohoku University
Institute of Materials Structure Science

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68 (!!!!! 2944.9462890625): select jos_facebook.link from jos_facebook where cat=10

69 (249.14741516113): select jos_google_plus.link from jos_google_plus where cat=10

70 (48.87580871582): select jos_linkedin.link from jos_linkedin where cat=10

71 (161.88621520996): SELECT fid FROM jos_deeppockets WHERE id=294781737 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294781737 AND published='1' LIMIT 1

72 (47.922134399414): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

73 (!!!!! 4801.0349273682): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294781737 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (!!!!! 1515.1500701904): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294781737 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (!!!!! 3077.0301818848): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (295.87745666504): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (279.90341186523): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (220.06034851074): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (159.02519226074): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (372.88665771484): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (411.9873046875): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (277.99606323242): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (258.20732116699): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (!!!!! 1250.0286102295): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294781737 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (360.01205444336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294781737 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (454.90264892578): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (726.93824768066): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (355.00526428223): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (200.98686218262): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (206.94732666016): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (224.82872009277): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (209.09309387207): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (900.0301361084): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

108 (907.18269348145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

109 (208.13941955566): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294781737 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (332.11708068848): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294781737 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 6924.8676300049): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

112 (!!!!! 1543.0450439453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

113 (89.168548583984): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294781737 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (789.16549682617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294781737 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (838.9949798584): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (775.09880065918): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

118 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

119 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

120 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

121 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

122 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

123 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

124 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

125 (464.91622924805): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

126 (!!!!! 32421.827316284): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

127 (842.09442138672): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294781737 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294781737 AND type='deeppockets_item' AND published='1' LIMIT 1

128 (85.115432739258): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (49.114227294922): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (58.174133300781): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (68.902969360352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (622.03407287598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (507.11631774902): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (57.220458984375): SELECT name FROM jos_deeppockets WHERE id=211

141 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=211

142 (817.06047058105): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (777.9598236084): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

145 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

146 (!!!!! 11492.013931274): TRUNCATE TABLE jos_trademed_module

147 (144.95849609375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294781737 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294781737 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (601.05323791504): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

152 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

153 (!!!!! 1662.9695892334): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

154 (96.797943115234): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

155 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

156 (58.889389038086): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294781737 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294781737 AND type='deeppockets_item' AND published='1' LIMIT 1

157 (44.822692871094): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

158 (40.054321289062): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

159 (51.021575927734): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

160 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

161 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781737 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781737 AND published='1' LIMIT 1

162 (54.121017456055): select jos_twitters.link from jos_twitters where cat=10

163 (37.908554077148): select jos_facebook.link from jos_facebook where cat=10

164 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10

165 (39.100646972656): select jos_linkedin.link from jos_linkedin where cat=10

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