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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Results of Metastatic Colorectal Cancer Study Released

By MedImaging International staff writers
Posted on 11 Jul 2017

Image: Researchers have found that adding SIRT to chemotherapy may boost colorectal cancer survival (Photo courtesy of MNT).

The results of a colorectal cancer study that compared standard first-line chemotherapy alone, and the same chemotherapy with Selective Internal Radiation Therapy (SIRT) treatment have been released.

The researchers reviewed the overall survival of the 1,103 patients who took part in the study. All patients had colorectal cancer that had spread to the liver. The patients were randomized to receive either only chemotherapy, or chemotherapy with SIRT radioembolization using SIR-Spheres Y-90 resin microspheres.

The results of the FOXFIRE Combined Analysis study were presented at the 2017 annual meeting of the American Society of Clinical Oncology (ASCO) by researchers from the University College London Cancer Institute (UCL; London, UK).

The patients had a median age of 63 years and had all been diagnosed with unresectable metastatic Colorectal Cancer (mCRC). The cancer had either metastasized to only the liver, or several additional parts of the body. The results did not show any significant difference in Overall Survival (OS) for the two groups, however an exploratory subgroup analysis of the FOXFIRE, SIRFLOX and FOXFIRE Global study did show that adding Y-90 resin microspheres to first-line chemotherapy for mCRC could increase OS in patients with right-sided primary colon tumors.

Co-principal investigator of the study, Professor Ricky Sharma, said, "Our analysis did not meet its primary endpoint of an overall survival (OS) benefit for patients treated with SIRT plus first-line chemotherapy compared to patients treated with chemotherapy alone. Nonetheless, I believe this study has significantly enriched scientific understanding of the role of SIRT in the management of metastatic colorectal cancer, particularly in the liver. Finding more effective treatments remains a critical issue for these patients. Following further validation, this unexpected finding may prove to be clinically meaningful as patients with right-sided primary colon tumors represent more than a third (35–38%) of all colon cancer patients."

Related Links:
University College London Cancer Institute

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69 (44.107437133789): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (313.04359436035): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769958 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (253.91578674316): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769958 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (57.93571472168): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (104.90417480469): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (76.055526733398): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769958 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (39.100646972656): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769958 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (41.007995605469): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (135.89859008789): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

105 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

106 (77.009201049805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769958 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769958 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (96.797943115234): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

109 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

110 (74.148178100586): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294769958 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (664.94941711426): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294769958 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (761.03210449219): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (715.97099304199): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

115 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

116 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

117 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

118 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

119 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

120 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

121 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

122 (409.84153747559): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 27446.985244751): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (638.00811767578): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769958 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769958 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 9433.0310821533): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (92.983245849609): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (358.10470581055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (321.86508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (288.96331787109): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (293.01643371582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (494.00329589844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (415.80200195312): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (272.03559875488): SELECT name FROM jos_deeppockets WHERE id=211

138 (57.93571472168): SELECT name FROM jos_deeppockets WHERE id=211

139 (731.9450378418): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (655.8895111084): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

142 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

143 (!!!!! 10828.971862793): TRUNCATE TABLE jos_trademed_module

144 (124.93133544922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769958 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769958 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (648.02169799805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

149 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

150 (!!!!! 1612.1864318848): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (135.89859008789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

152 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

153 (66.995620727539): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769958 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769958 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (596.04644775391): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (56.982040405273): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (59.843063354492): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

158 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769958 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769958 AND published='1' LIMIT 1

159 (116.82510375977): select jos_twitters.link from jos_twitters where cat=10

160 (32.901763916016): select jos_facebook.link from jos_facebook where cat=10

161 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

162 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

163 (279.90341186523): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1290.0829315186): insert into jos_banners_delta values (14615,'2025-06-20 23:10:36','216.73.216.120','view'),(14202,'2025-06-20 23:10:36','216.73.216.120','view'),(14203,'2025-06-20 23:10:36','216.73.216.120','view')

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