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Trained Radiologists Can Detect Breast Cancer in An Instant

By MedImaging International staff writers
Posted on 15 Sep 2016

Researchers at Brigham and Women's Hospital (BWH; Boston, AM, USA), the University of York (United Kingdom), and other institutions showed radiologists mammograms for half a second, and found that they could identify abnormal mammograms at better than chance levels. They further tested this ability through a series of four experiments to explore what signal may alert radiologists to the presence of a possible abnormality, in the hopes of using these insights to improve breast cancer screening and early detection.

They found that radiologist performance did not depend on detection of breaks in the normal symmetry of left and right breasts. Moreover, above-chance classification is possible using images from the normal breast of a patient, even when overt signs of cancer are present only in the other breast. They speculate that parts of the parenchyma that do not contain a lesion, or that are in the contralateral breast, confer an abnormal ‘gist’ that may be based on a widely distributed image statistic that is learned by experts. The study was published on August 29, 2016, in Proceedings of the National Academy of Sciences (PNAS).

“Radiologists can have ‘hunches’ after a first look at a mammogram. We found that these hunches are based on something real in the images. It's really striking that in the blink of an eye, an expert can pick up on something about that mammogram that indicates abnormality,” said senior author Jeremy Wolfe, PhD, director of the Visual Attention Laboratory at BWH. “Not only that, but they can detect something abnormal in the other breast, the breast that does not contain a lesion. Radiologists may be picking up on some sort of early, global signal of abnormality that is unknown to us at this point.”

According to the researchers, defining the signal that experienced radiologists are detecting could help researchers refine and improve computer-aided detection (CAD) systems that can aid in medical screening and could be incorporated into clinician training to improve detection rates. The researchers are also interested in exploring whether other medical image experts, such as dermatologists and pathologists, can use analogous signals.

Related Links:
Brigham and Women's Hospital
University of York

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68 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE id=294766029 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294766029 AND published='1' LIMIT 1

69 (33.855438232422): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (447.98851013184): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294766029 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (279.90341186523): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294766029 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (56.028366088867): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (79.870223999023): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (51.975250244141): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294766029 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (452.99530029297): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294766029 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (49.114227294922): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1425.9815216064): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

105 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

106 (103.95050048828): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294766029 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (606.06002807617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294766029 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 5774.974822998): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

109 (460.14785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

110 (60.081481933594): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294766029 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1001.1196136475): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294766029 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1133.2035064697): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (914.09683227539): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (279.90341186523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

115 (519.99092102051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

116 (692.12913513184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

117 (363.82675170898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

118 (166.17774963379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

119 (189.06593322754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

120 (210.04676818848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

121 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

122 (447.98851013184): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 63582.181930542): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (906.94427490234): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294766029 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294766029 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 17357.110977173): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (59.127807617188): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 1213.0737304688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (69.141387939453): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (42.200088500977): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (654.22058105469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (147.81951904297): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (687.1223449707): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 4740.9534454346): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 1343.0118560791): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (293.97010803223): SELECT name FROM jos_deeppockets WHERE id=211

138 (43.869018554688): SELECT name FROM jos_deeppockets WHERE id=211

139 (979.90036010742): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1095.0565338135): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 3165.9603118896): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

142 (583.88710021973): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

143 (!!!!! 20521.879196167): TRUNCATE TABLE jos_trademed_module

144 (923.87199401855): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294766029 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (347.13745117188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294766029 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1090.0497436523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 2587.7952575684): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

149 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

150 (!!!!! 2783.0600738525): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 1472.9499816895): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

152 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

153 (245.09429931641): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294766029 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294766029 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (45.061111450195): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (!!!!! 3177.1659851074): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (546.21696472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

158 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294766029 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294766029 AND published='1' LIMIT 1

159 (336.1701965332): select jos_twitters.link from jos_twitters where cat=10

160 (207.18574523926): select jos_facebook.link from jos_facebook where cat=10

161 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

162 (43.869018554688): select jos_linkedin.link from jos_linkedin where cat=10

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