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Imaging Shows Asymptomatic Atherosclerosis Linked to Cognitive Impairment

By MedImaging International staff writers
Posted on 07 Dec 2014

In an imaging study of nearly 2,000 adults, researchers found that an accumulation of plaque in the body’s major arteries was linked with mild cognitive impairment. More...

The study’s findings were conducted at the University of Texas (UT) Southwestern Medical Center (Dallas, USA) and presented December 2014 at the annual meeting of the Radiological Society of North America (RSNA), held in Chicago (IL, USA). “It is well established that plaque buildup in the arteries is a predictor of heart disease, but the relationship between atherosclerosis and brain health is less clear,” said Christopher D. Maroules, MD, a radiology resident at UT Southwestern Medical Center in Dallas. “Our findings suggest that atherosclerosis not only affects the heart but also brain health.”

Atherosclerosis is a disorder in which cholesterol, fat, and other substances gather in the arteries, forming a substance called plaque that can build up, restricting blood flow. It can occur in any artery of the body, including the carotid, which supplies blood to the brain, coronary arteries and the aorta, which carries oxygenated blood from the heart through the abdomen to the rest of body.

In the study, researchers analyzed the test results of 1,903 participants (mean age, 44 years) in the Dallas Heart Study, a multiethnic population-based study of adults from Dallas County, Texas. The participants included both men and women who had no symptoms of cardiovascular disease. Study participants completed the Montreal Cognitive Assessment (MoCA), a 30-point standardized test for detecting mild cognitive impairment, and underwent magnetic resonance imaging (MRI) of the brain to identify white matter hyperintensity (WMH) volume. Bright white spots known as high signal intensity areas on a brain MR images indicate abnormal changes within the white matter. “Increased white matter hyperintensity volume is part of the normal aging process,” Dr. Maroules explained. “But excessive WMH volume is a marker for cognitive impairment.”

Study participants also underwent imaging exams to measure the buildup of plaque in the arteries in three distinct vascular areas of the body: MRI to measure wall thickness in the carotid arteries and the abdominal aorta, and computed tomography (CT) to measure coronary artery calcium, or the amount of calcified plaque in the arteries of the heart.

Using the findings, researchers performed a statistical regression to correlate the incidence of atherosclerosis and mild cognitive impairment. After adjusting for traditional risk factors for atherosclerosis, including age, ethnicity, male sex, diabetes, hypertension, smoking, and body mass index, they found independent relationships between atherosclerosis in all three vascular areas of the body and cognitive health, as measured by MoCA scores and white matter hyperintensity volume on MR images.

Individuals in the highest quartile of internal carotid wall thickness were 21% more likely to have cognitive impairment as measured by a low MoCA score. An increasing coronary artery calcium score was predictive of large white matter intensity volume on MRI. “These results underscore the importance of identifying atherosclerosis in its early stages, not just to help preserve heart function, but also to preserve cognition and brain health,” Dr. Maroules said.

Dr. Maroules noted that the MRI and CT imaging techniques provide valuable prognostic information about an individual’s downstream health risks. “Plaque buildup in blood vessels throughout the body offers us a window into brain health,” he said. “Imaging with CT and MRI has an important role in identifying patients who are at a higher risk for cognitive impairment.”

RSNA (Oak Brook, IL, USA) is an association of more than 54,000 radiologists, radiation oncologists, medical physicists and related scientists, encouraging excellence in patient care and health care delivery through education, research and technologic advances.

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University of Texas Southwestern Medical Center

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59 (!!!!! 1663.2080078125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

60 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

61 (149.01161193848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

62 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

63 (143.05114746094): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (740.05126953125): SELECT fid FROM jos_deeppockets WHERE id=294756078 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294756078 AND published='1' LIMIT 1

65 (74.863433837891): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

66 (77.962875366211): select jos_twitters.link from jos_twitters where cat=10

67 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

68 (37.193298339844): select jos_google_plus.link from jos_google_plus where cat=10

69 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

70 (54.121017456055): SELECT fid FROM jos_deeppockets WHERE id=294756078 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294756078 AND published='1' LIMIT 1

71 (51.975250244141): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

72 (484.94338989258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756078 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (375.03242492676): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756078 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (66.041946411133): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (97.990036010742): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (47.206878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (52.213668823242): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (88.930130004883): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756078 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (49.114227294922): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756078 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (60.081481933594): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (77.962875366211): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (100.85105895996): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (312.08992004395): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

107 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

108 (89.883804321289): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756078 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756078 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (109.91096496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

111 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

112 (74.863433837891): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294756078 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (814.91470336914): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294756078 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (603.91426086426): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (510.93101501465): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

117 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

118 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

119 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

120 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

121 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

122 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

123 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

124 (335.9317779541): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 35588.979721069): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (814.91470336914): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756078 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756078 AND type='deeppockets_item' AND published='1' LIMIT 1

127 (!!!!! 11634.111404419): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (124.93133544922): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (83.92333984375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (73.909759521484): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (442.9817199707): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (126.83868408203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (62.942504882812): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (580.0724029541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (395.05958557129): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (66.041946411133): SELECT name FROM jos_deeppockets WHERE id=211

140 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=211

141 (691.17546081543): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (526.90505981445): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (119.20928955078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

144 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

145 (!!!!! 9981.8706512451): TRUNCATE TABLE jos_trademed_module

146 (117.06352233887): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756078 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756078 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (!!!!! 1204.0138244629): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (91.791152954102): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

151 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

152 (!!!!! 1502.0370483398): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (110.14938354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

154 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

155 (105.85784912109): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756078 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756078 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (40.054321289062): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

157 (41.007995605469): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

158 (66.041946411133): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (180.00602722168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

160 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756078 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756078 AND published='1' LIMIT 1

161 (85.115432739258): select jos_twitters.link from jos_twitters where cat=10

162 (48.160552978516): select jos_facebook.link from jos_facebook where cat=10

163 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10

164 (46.014785766602): select jos_linkedin.link from jos_linkedin where cat=10

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