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Soft Tissue Radiotherapy Real-Time Tracking Device Receives Approval

By MedImaging International staff writers
Posted on 29 Jul 2014

Image: Calyspo - GPS for the body (Photo courtesy of Varian).

New US clearance expands the indications for which clinicians will be able to use a real-time tracking device for monitoring motion during radiotherapy treatments for cancer.

Varian Medical Systems (Palo Alto, CA, USA) has received 510(k) clearance from the US Food and Drug Administration (FDA) for a Calypso soft tissue Beacon transponder that can help enhance the precision of radiotherapy and radiosurgery treatments for cancer.

The new transponders, which are the size of a grain of rice, can be implanted within soft tissue throughout the body, with the exception of the lung. The Calypso GPS for the Body system can then continuously track and monitor the position of the transponders, so that the high energy treatment beams can be precisely aimed to minimize exposure of surrounding healthy tissues. An earlier version of the Calypso Beacon transponder was cleared for use specifically in the prostate and prostatic bed; the new clearance makes the system applicable for many other types of cancer.

Calypso Beacon transponders emit a nonionizing electromagnetic signal that is monitored in real time by the Calypso system, in order to guide treatment beams to precisely target tumors during radiotherapy and radiosurgery with medical linear accelerators, such as Varian’s Edge radiosurgery system.

“With the new transponder, clinicians can use the Calypso system most places they would have used standard fiducial markers, such as gold seeds, to localize a targeted tumor, but with the added benefit of continuous tumor position tracking throughout treatment delivery,” said Andrea Morgan, Calypso product manager. “Other types of fiducial markers have to be localized using X-rays, which add more ionizing radiation to the process. We’re pleased to be able to make the system available to clinicians who want to use it more broadly, not just for conventional radiotherapy but for some of the newer approaches, like stereotactic body radiotherapy [SBRT], which involves delivering higher radiation doses very quickly. For treatments like that, accurate targeting is essential, and the new Calypso transponders have an important role to play.”

“I have been using standard fiducial markers, particularly when treating tumors of the pancreas and liver,” said Mary Feng, MD, associate professor in the department of radiation oncology at the University of Michigan (Ann Arbor, USA). “It is essential that we know exactly where the tumor is at all times, and that we have a way of responding if the tumor moves during treatment. I’m excited about the prospect of using the Calypso tracking system treating in areas where it is very hard to see the tumor because of the lack of contrast with surrounding soft tissues.”

The new Calypso soft tissue Beacon transponders can only be used with the latest upgrade of the Varian Calypso system (version 3.0). Current Calypso Beacon transponders for the prostate are not suitable for the new soft tissue indication due to device and labeling differences. “Initial use of the new device is expected towards the end of the year,” said Corey Zankowski, vice president of product management at Varian. “We anticipate full commercial roll-out of the product sometime next year.”

Calypso soft tissue Beacon transponders are cleared for the US market only.

The Calypso system, including its Beacon transponders, was designed to align and/or monitor the patient’s position in relation to the radiation beam used for treatment. The Calypso system may also be used to regulate the treatment beam on Varian and Siemens Healthcare (Erlangen, Germany) radiation delivery systems by turning the beam on and off due to movement during treatment. Beacon transponders used as part of the system for monitoring patient motion are indicated for use on the skin surface for temporary external placement and for permanent implantation, specifically in the prostate and prostatic bed as well as in soft tissue.

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63 (277.99606323242): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (41.961669921875): select jos_twitters.link from jos_twitters where cat=10

65 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

66 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

67 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

68 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=294753715 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294753715 AND published='1' LIMIT 1

69 (57.93571472168): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (252.96211242676): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753715 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (217.91458129883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753715 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (96.797943115234): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753715 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (28.848648071289): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753715 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (33.140182495117): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

105 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

106 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753715 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753715 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

109 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

110 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753715 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (492.09594726562): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753715 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (555.03845214844): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (353.09791564941): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

115 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

116 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

117 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

118 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

119 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

120 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

121 (55.789947509766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

122 (478.02925109863): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753715 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753715 AND type='deeppockets_item' AND published='1' LIMIT 1

123 (!!!!! 445122.95722961): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

124 (108.00361633301): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

125 (144.95849609375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

126 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

127 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

128 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

129 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

130 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

131 (519.99092102051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

132 (432.01446533203): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

133 (230.07392883301): SELECT name FROM jos_deeppockets WHERE id=211

134 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=211

135 (473.97613525391): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

136 (375.98609924316): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

137 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

138 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

139 (329.01763916016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

142 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

143 (!!!!! 1393.0797576904): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

144 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

145 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

146 (37.908554077148): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753715 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753715 AND type='deeppockets_item' AND published='1' LIMIT 1

147 (395.05958557129): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

148 (36.954879760742): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

149 (34.093856811523): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

150 (126.12342834473): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

151 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753715 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753715 AND published='1' LIMIT 1

152 (32.901763916016): select jos_twitters.link from jos_twitters where cat=10

153 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

154 (58.889389038086): select jos_google_plus.link from jos_google_plus where cat=10

155 (32.186508178711): select jos_linkedin.link from jos_linkedin where cat=10

156 (307.08312988281): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

157 (!!!!! 1327.0378112793): insert into jos_banners_delta values (14615,'2025-06-19 05:48:51','216.73.216.120','view'),(14202,'2025-06-19 05:48:51','216.73.216.120','view'),(14203,'2025-06-19 05:48:51','216.73.216.120','view')

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