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New Agent Could Enhance Effectiveness of Radiotherapy

By MedImaging International staff writers
Posted on 27 May 2014

Scientists have demonstrated the potential of a drug to enhance the effectiveness of radiotherapy in stopping tumor growth.

There is increasing interest in using the body’s own immune system to attack tumor cells—an approach that can be very effective without the side effects linked with traditional chemotherapy.

Skin cancers have been effectively treated using a topical cream, imiquimod, which recruits immune cells through a molecule called toll-like receptor 7 (TLR7), a protein that recognizes foreign and potentially damaging substances. Earlier, researchers from the University of Manchester (part of the Manchester Cancer Research Centre; UK) have shown that they can also trigger the immune system into producing an immune response against non-skin cancers by injecting an agent similar to TLR7 into the blood.

Working with AstraZeneca (London, UK) and Dainippon Sumitomo Pharma (Osaka, Japan), the British group of investigators have examined at another molecule that activates TLR7, known as DSR-6434. Using mouse models of two different types of cancer, they evaluated DSR-6434 on its own and in combination with radiotherapy and gauged the effect on the primary tumor and the number of secondary tumors in the lungs.

Prof. Ian Stratford, from Manchester Pharmacy School, who, with Prof. Tim Illidge, who led the study, which was published online January 2014 in the International Journal of Cancer, said, “We have already seen a strong immune system response from other immunotherapy agents in combination with radiation--this new agent appears to be even more potent.”

The investigators revealed that giving DSR-6434 combined with radiotherapy led to tumor shrinkage and increased long-term survival. They discovered that the combination treatment also reduced the occurrence of secondary lung tumors. “It looks like there’s good reason to use radiotherapy alongside immunotherapy agents in the treatment of solid tumors. These results strongly suggest that this sort of combination therapy should be evaluated in clinical trials with cancer patients,” added Prof. Stratford.

Related Links:
Manchester Cancer Research Center
AstraZeneca
Dainippon Sumitomo Pharma

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68 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

69 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE id=294752671 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294752671 AND published='1' LIMIT 1

70 (48.160552978516): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

71 (!!!!! 5712.0323181152): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752671 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 3937.0059967041): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752671 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (176.19132995605): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (374.07875061035): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (80.108642578125): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (285.86387634277): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (638.00811767578): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (116.82510375977): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (444.88906860352): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 4477.0240783691): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (416.99409484863): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (315.18936157227): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 2648.1151580811): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (!!!!! 1684.9040985107): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752671 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (94.175338745117): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752671 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (69.856643676758): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (577.21138000488): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (180.95970153809): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (168.80035400391): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (!!!!! 2041.1014556885): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 4383.0871582031): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (!!!!! 3889.0838623047): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (106.0962677002): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (!!!!! 1835.823059082): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

106 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

107 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752671 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (511.16943359375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752671 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (!!!!! 3450.1552581787): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

110 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

111 (52.213668823242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752671 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (566.00570678711): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752671 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (854.9690246582): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 4617.2142028809): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

116 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

117 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

118 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

119 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

120 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

121 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

122 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

123 (233.88862609863): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 59252.977371216): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (!!!!! 1070.0225830078): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752671 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752671 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 3983.0207824707): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 2381.0863494873): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (122.0703125): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (259.8762512207): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (329.01763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (75.101852416992): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (169.99244689941): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (77.009201049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (771.99935913086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (702.85797119141): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (171.89979553223): SELECT name FROM jos_deeppockets WHERE id=211

139 (122.7855682373): SELECT name FROM jos_deeppockets WHERE id=211

140 (751.97219848633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1025.1998901367): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (483.98971557617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

143 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

144 (!!!!! 16115.90385437): TRUNCATE TABLE jos_trademed_module

145 (!!!!! 2238.0352020264): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752671 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (241.99485778809): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752671 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (!!!!! 1465.0821685791): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (149.96528625488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (!!!!! 3671.1692810059): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

150 (274.8966217041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

151 (!!!!! 2030.8494567871): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (!!!!! 1088.8576507568): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

153 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

154 (309.94415283203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752671 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752671 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (149.01161193848): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (343.08433532715): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

157 (251.77001953125): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (!!!!! 1007.080078125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

159 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752671 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752671 AND published='1' LIMIT 1

160 (!!!!! 2852.201461792): select jos_twitters.link from jos_twitters where cat=10

161 (219.82192993164): select jos_facebook.link from jos_facebook where cat=10

162 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

163 (542.87910461426): select jos_linkedin.link from jos_linkedin where cat=10

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