Download Mobile App

Video Library

Radiotherapy for Brain Cancer May Be Improved by Blocking DNA Repair Processes

By MedImaging International staff writers
Posted on 30 Apr 2014

Researchers have demonstrated in both cancer cell lines and mice that shutting down critical DNA repair processes could enhance the effectiveness of radiation therapy for highly fatal brain tumors called glioblastomas.

Radiation therapy causes double-strand breaks in DNA that must be fixed for tumors to keep growing. Scientists have long theorized that if they could find a way to block repairs from being made, they could prevent tumors from growing or at least slow down the growth, thereby extending patients' survival. Blocking DNA repair is a particularly attractive strategy for treating glioblastomas, as these tumors are highly resistant to radiation therapy. In a new study, University of Texas (UT) Southwestern Medical Center (Dallas, USA) researchers demonstrated that the hypothesis actually works in the context of glioblastomas.

“This work is informative because the findings show that blocking the repair of DNA double-strand breaks could be a viable option for improving radiation therapy of glioblastomas,” said Dr. Sandeep Burma, associate professor of radiation oncology in the division of molecular radiation biology at UT Southwestern.

Dr. Burma researches the determination of basic mechanisms by which DNA breaks are repaired, with the translational objective of improving cancer therapy with DNA-damaging agents. Recent research from his lab has demonstrated how a cell makes the choice between two major pathways that are used to repair DNA breaks—non-homologous end joining (NHEJ) and homologous recombination (HR). His lab found that enzymes involved in cell division called cyclin-dependent kinases (CDKs) activate HR by phosphorylating a key protein, EXO1. In this manner, the use of HR is coupled to the cell division cycle, and this has important implications for cancer therapeutics. These findings were published April 7, 2014, in the journal Nature Communications.

Whereas this study describes how the cell chooses between NHEJ and HR, a translational study from the Burma lab demonstrates how blocking both repair pathways can improve radiotherapy of glioblastomas. Researchers in the lab first were able to show in glioblastoma cell lines that a drug called NVP-BEZ235, which is in clinical trials for other solid tumors, can also suppress two key DNA repair enzymes, DNA-PKcs and ATM, which are crucial for NHEJ and HR, respectively. While the drug by itself had limited effect, when combined with radiation therapy, the tumor cells could not quickly repair their DNA, stalling their growth.

Although enthusiastic by the early findings in cell lines, the scientists remained guarded because earlier efforts to identify DNA repair inhibitors were not successful when used in living models—mice with glioblastomas. Drugs developed to treat brain tumors also must cross what's known as the blood-brain-barrier in living models.

However, the NVP-BEZ235 drug could effectively cross the blood-brain barrier, and when given to mice with glioblastomas and combined with radiation, the tumor growth in mice was inhibited and the mice survived a lot longer, up to 60 days compared to approximately 10 days with the drug or radiation therapy alone. These findings were published in a recent issue of Clinical Cancer Research.

“The consequence is striking,” said Dr. Burma. “If you irradiate the tumors, nothing much happens because they grow right through radiation. Give the drug alone, and again, nothing much happens. But when you give the two together, tumor growth is delayed significantly. The drug has a very striking synergistic effect when given with radiation.”

The combination effect is significant because the conventional therapy for glioblastomas in humans is radiation therapy; therefore, finding a drug that enhances the effectiveness of radiation therapy could have profound clinical importance eventually. For example, such drugs may permit lower doses of X-rays and gamma rays to be used for traditional therapies, thereby causing fewer side effects. “Radiation is still the mainstay of therapy, so we have to have something that will work with the mainstay of therapy,” Dr. Burma said.

Whereas the findings provide evidence that the theory of “radiosensitizing” glioblastomas works in mouse models, additional research and clinical trials will be needed to show whether the combination of radiation with DNA repair inhibitors would be effective in humans, Dr. Burma cautioned. “Double-strand DNA breaks are a double-edged sword,” he said. “On one hand, they cause cancer. On the other, we use ionizing radiation and chemotherapy to cause double-strand breaks to treat the disease.”

“Heavy particles cause dense tracks of damage, which are very hard to repair,” Dr. Burma noted. “With gamma or X-rays, which are used in medical therapy, the damage is diffuse and is repaired within a day. If you examine a mouse brain irradiated with heavy particles, the damage is repaired slowly and can last for months.”

These findings, published March 17, 2014, in the journal Oncogene, suggest that glioblastoma risk from heavier particles is much higher compared to that from gamma or X-rays. This study is relevant to the medical field, since ionizing radiation, even low doses from computed tomography (CT) scans, have been reported to increase the risk of brain tumors, according to Dr. Burma.

Related Links:
University of Texas Southwestern Medical Center

Visit expo >

Gold Member

Ultrasound System

FUTUS LE

Gold Member

Electrode Solution and Skin Prep

Signaspray

3D Mammography Software

ProFound AI

Radiography System

ANTARIX II PLUS

Latest Radiography News

Channels

MRI

view channel

Image: An AI tool has shown tremendous promise for predicting relapse of pediatric brain cancer (Photo courtesy of 123RF)

AI Tool Predicts Relapse of Pediatric Brain Cancer from Brain MRI Scans

Many pediatric gliomas are treatable with surgery alone, but relapses can be catastrophic. Predicting which patients are at risk for recurrence remains challenging, leading to frequent follow-ups with... Read more

AI Tool Tracks Effectiveness of Multiple Sclerosis Treatments Using Brain MRI Scans

Multiple sclerosis (MS) is a condition in which the immune system attacks the brain and spinal cord, leading to impairments in movement, sensation, and cognition. Magnetic Resonance Imaging (MRI) markers... Read more

Ultra-Powerful MRI Scans Enable Life-Changing Surgery in Treatment-Resistant Epileptic Patients

Approximately 360,000 individuals in the UK suffer from focal epilepsy, a condition in which seizures spread from one part of the brain. Around a third of these patients experience persistent seizures... Read more

Image: The automated MRI processing and machine learning software features a noninvasive biomarker technique (Photo courtesy of University of Florida)

AI-Powered MRI Technology Improves Parkinson’s Diagnoses

Current research shows that the accuracy of diagnosing Parkinson’s disease typically ranges from 55% to 78% within the first five years of assessment. This is partly due to the similarities shared by Parkinson’s... Read more

Ultrasound

view channel

AI-Powered Lung Ultrasound Outperforms Human Experts in Tuberculosis Diagnosis

Despite global declines in tuberculosis (TB) rates in previous years, the incidence of TB rose by 4.6% from 2020 to 2023. Early screening and rapid diagnosis are essential elements of the World Health... Read more

Image: Researchers are using AI to analyze images from a common heart test to identify signs of valve disease (Photo courtesy of 123RF)

AI Identifies Heart Valve Disease from Common Imaging Test

Tricuspid regurgitation is a condition where the heart's tricuspid valve does not close completely during contraction, leading to backward blood flow, which can result in heart failure. A new artificial... Read more

Image: Diagram of ULM processing (Photo courtesy of Cyborg and Bionic Systems)

Novel Imaging Method Enables Early Diagnosis and Treatment Monitoring of Type 2 Diabetes

Type 2 diabetes is recognized as an autoimmune inflammatory disease, where chronic inflammation leads to alterations in pancreatic islet microvasculature, a key factor in β-cell dysfunction.... Read more

Image: Artist’s impression of the new ultrasound technique, called nonlinear sound sheet microscopy (Photo courtesy of Maayan Harel/Maresca Lab)

Ultrasound-Based Microscopy Technique to Help Diagnose Small Vessel Diseases

Clinical ultrasound, commonly used in pregnancy scans, provides real-time images of body structures. It is one of the most widely used imaging techniques in medicine, but until recently, it had little... Read more

Nuclear Medicine

view channel

Image: In vivo imaging of U-87 MG xenograft model with varying mass doses of 89Zr-labeled KLG-3 or isotype control (Photo courtesy of L Gajecki et al.; doi.org/10.2967/jnumed.124.268762)

General/Advanced Imaging

view channel

Image: The LungVision system has received regulatory approval from the TGA in Australia (Photo courtesy of Body Vision Medical)

AI-Powered Imaging System Improves Lung Cancer Diagnosis

Given the need to detect lung cancer at earlier stages, there is an increasing need for a definitive diagnostic pathway for patients with suspicious pulmonary nodules. However, obtaining tissue samples... Read more

Image: The multimodal multitask foundation model enhances lung cancer screening (Photo courtesy of 123RF)

AI Model Significantly Enhances Low-Dose CT Capabilities

Lung cancer remains one of the most challenging diseases, making early diagnosis vital for effective treatment. Fortunately, advancements in artificial intelligence (AI) are revolutionizing lung cancer... Read more

Image: Axial noncontrast chest CT lung window images of three different sample patches shown in each row (Photo courtesy of Radiology: Cardiothoracic Imaging)

Ultra-Low Dose CT Aids Pneumonia Diagnosis in Immunocompromised Patients

Lung infections can be life-threatening for patients with weakened immune systems, making timely diagnosis crucial. While CT scans are considered the gold standard for detecting pneumonia, repeated scans... Read more

Image: Histologically confirmed lung cancer cases detected at immediate referral after baseline scan or 3-month short-term follow-up (Photo courtesy of DOI:10.1016/j.ejca.2025.115324)

AI Reduces CT Lung Cancer Screening Workload by Almost 80%

Lung cancer impacts over 48,000 individuals in the UK annually, and early detection is key to improving survival rates. The UK Lung Cancer Screening (UKLS) trial has already shown that low-dose CT (LDCT)... Read more

Imaging IT

view channel

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology

The global artificial intelligence (AI) in medical diagnostics market is expanding with early disease detection being one of its key applications and image recognition becoming a compelling consumer proposition... Read more

AI-Based Mammography Triage Software Helps Dramatically Improve Interpretation Process

An artificial intelligence (AI)-based mammography triage software is helping dramatically improve the interpretation process for healthcare providers. In a new study, researchers at the Scripps Green... Read more

Artificial Intelligence (AI) Program Accurately Predicts Lung Cancer Risk from CT Images

An artificial intelligence (AI) program accurately predicts the risk that lung nodules detected on screening CT will become cancerous, according to a study published in the journal Radiology.... Read more

Industry News

view channel

GE HealthCare and NVIDIA Collaboration to Reimagine Diagnostic Imaging

GE HealthCare (Chicago, IL, USA) has entered into a collaboration with NVIDIA (Santa Clara, CA, USA), expanding the existing relationship between the two companies to focus on pioneering innovation in... Read more

Image: The patient-specific 3D-printed phantoms usher in a new era for medical imaging research (Photo courtesy of Siemens Healthineers)

Patient-Specific 3D-Printed Phantoms Transform CT Imaging

New research has highlighted how anatomically precise, patient-specific 3D-printed phantoms are proving to be scalable, cost-effective, and efficient tools in the development of new CT scan algorithms... Read more

Siemens and Sectra Collaborate on Enhancing Radiology Workflows

Siemens Healthineers (Forchheim, Germany) and Sectra (Linköping, Sweden) have entered into a collaboration aimed at enhancing radiologists' diagnostic capabilities and, in turn, improving patient care... Read more

Image: Virtual colonoscopy (CT colonography) is an approved option for screening for colorectal cancer in the US (Photo courtesy of Shtutterstock)

Bracco Diagnostics and ColoWatch Partner to Expand Availability CRC Screening Tests Using Virtual Colonoscopy

Over the last 25 years, virtual colonoscopy has been proven to be a highly accurate, safe, convenient, and cost-effective method of colorectal cancer (CRC) prevention and screening. It can reliably find... Read more

1 (430.82237243652): SET sql_mode = 'MYSQL40'

2 (!!!!! 7836.1034393311): SELECT folder, element, published, params FROM jos_mambots WHERE published >= 1 AND access <= 0 AND folder = 'system' ORDER BY ordering

3 (499.01008605957): SELECT template FROM jos_templates_menu WHERE client_id = 0 AND ( menuid = 0 OR menuid = 294752183 ) ORDER BY menuid DESC LIMIT 1

4 (!!!!! 2592.0867919922): DELETE FROM jos_session WHERE time < 1755486515 AND guest = 1 AND userid = 0

5 (127.07710266113): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

6 (53.882598876953): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

7 (43.869018554688): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

8 (!!!!! 9629.0111541748): SELECT * FROM jos_menu WHERE id = 294752183

9 (!!!!! 2692.9378509521): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

10 (!!!!! 1656.0554504395): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

11 (462.05520629883): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

12 (!!!!! 1860.1417541504): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294752183) AND (fid=211) ORDER BY id DESC, `created` DESC LIMIT 0,16

13 (793.9338684082): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294752183) AND (fid=211) ORDER BY id DESC, `created` DESC LIMIT 0,16

14 (!!!!! 6017.2080993652): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=211 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294752183 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

15 (!!!!! 10746.955871582): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=211 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294752183 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

16 (!!!!! 2628.0879974365): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294752183 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

17 (!!!!! 4400.0148773193): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294752183 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

18 (!!!!! 2571.1059570312): SELECT name,id,title FROM jos_deeppockets WHERE id=211 LIMIT 1

19 (57.93571472168): SELECT name,id,title FROM jos_deeppockets WHERE id=211 LIMIT 1

20 (713.10997009277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

21 (573.15826416016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

22 (523.80561828613): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

23 (!!!!! 3024.1012573242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

24 (790.11917114258): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

25 (665.90309143066): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

26 (!!!!! 4317.045211792): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

27 (184.05914306641): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

28 (!!!!! 3700.0179290771): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

29 (199.0795135498): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

30 (175.95291137695): SELECT conference_items.channel_id, conference_items.tracking_code FROM conference_items LEFT JOIN conference_groups ON conference_groups.id = conference_items.group_id LEFT JOIN jos_deeppockets ON jos_deeppockets.id = conference_items.channel_id LEFT JOIN jos_journal ON jos_journal.cat = jos_deeppockets.cat AND jos_journal.real = 1 AND jos_journal.directory IS NOT NULL WHERE 1 = 1 ORDER BY conference_items.id

31 (478.02925109863): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294752183 LIMIT 1

32 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294752183 LIMIT 1

33 (353.81317138672): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294752183 LIMIT 1

34 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294752183 LIMIT 1

35 (128.03077697754): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294752183 LIMIT 1

36 (79.154968261719): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294752183 LIMIT 1

37 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294752183 LIMIT 1

38 (!!!!! 1328.9451599121): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294752183 LIMIT 1

39 (!!!!! 1287.9371643066): SELECT id, title, module, position, content, showtitle, params FROM jos_modules AS m INNER JOIN jos_modules_menu AS mm ON mm.moduleid = m.id WHERE m.published = 1 AND m.access <= 0 AND m.client_id != 1 AND ( mm.menuid = 0 OR mm.menuid = 294752183 ) ORDER BY ordering

40 (!!!!! 5681.9915771484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

41 (787.01972961426): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

42 (80.108642578125): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 98 AND `site_id` = 10 AND `published` = 1

43 (48.87580871582): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 99 AND `site_id` = 10 AND `published` = 1

44 (!!!!! 4176.139831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

45 (140.19012451172): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

46 (!!!!! 4328.9661407471): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

47 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

48 (!!!!! 1736.8793487549): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

49 (335.9317779541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

50 (!!!!! 2239.9425506592): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

51 (100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

52 (!!!!! 1067.8768157959): SELECT name FROM jos_deeppockets WHERE id=294752183 LIMIT 1

53 (346.89903259277): SELECT name FROM jos_deeppockets_archive WHERE id=294752183 LIMIT 1

54 (378.13186645508): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

55 (179.05235290527): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

56 (996.82807922363): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 3056.0493469238): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

58 (!!!!! 3954.8873901367): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

59 (229.83551025391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

60 (140.19012451172): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

61 (255.10787963867): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (508.06999206543): SELECT fid FROM jos_deeppockets WHERE id=294752183 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294752183 AND published='1' LIMIT 1

63 (!!!!! 6282.0911407471): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (403.88107299805): select jos_twitters.link from jos_twitters where cat=10

65 (56.028366088867): select jos_facebook.link from jos_facebook where cat=10

66 (347.85270690918): select jos_google_plus.link from jos_google_plus where cat=10

67 (152.8263092041): select jos_linkedin.link from jos_linkedin where cat=10

68 (92.029571533203): SELECT fid FROM jos_deeppockets WHERE id=294752183 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294752183 AND published='1' LIMIT 1

69 (!!!!! 6249.9046325684): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (705.95741271973): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752183 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 10711.908340454): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752183 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 7901.9069671631): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (336.1701965332): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (98.943710327148): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (128.98445129395): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (197.8874206543): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (85.115432739258): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (111.10305786133): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (195.98007202148): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (81.777572631836): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (111.81831359863): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (416.04042053223): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (235.08071899414): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (285.86387634277): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (216.96090698242): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (97.036361694336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 3432.9891204834): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752183 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (80.108642578125): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752183 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 4346.1322784424): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

105 (126.83868408203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

106 (65.088272094727): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

109 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

110 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (446.79641723633): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (576.01928710938): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (382.90023803711): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

115 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

116 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

117 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

118 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

119 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

120 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

121 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

122 (277.99606323242): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 36123.037338257): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (608.92105102539): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752183 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752183 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (76.055526733398): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (44.107437133789): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (785.11238098145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (599.14588928223): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (43.153762817383): SELECT name FROM jos_deeppockets WHERE id=211

138 (30.994415283203): SELECT name FROM jos_deeppockets WHERE id=211

139 (597.95379638672): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (443.93539428711): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

142 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

143 (!!!!! 13449.907302856): TRUNCATE TABLE jos_trademed_module

144 (106.0962677002): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (60.081481933594): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752183 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (703.09638977051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

149 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

150 (!!!!! 1142.0249938965): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

152 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

153 (38.862228393555): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752183 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752183 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (35.04753112793): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (173.09188842773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

158 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752183 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752183 AND published='1' LIMIT 1

159 (39.100646972656): select jos_twitters.link from jos_twitters where cat=10

160 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

161 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

162 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

Download Mobile App

Video Library

Radiotherapy for Brain Cancer May Be Improved by Blocking DNA Repair Processes

Latest Radiography News

Channels

MRI

AI Tool Predicts Relapse of Pediatric Brain Cancer from Brain MRI Scans

AI Tool Tracks Effectiveness of Multiple Sclerosis Treatments Using Brain MRI Scans

Ultra-Powerful MRI Scans Enable Life-Changing Surgery in Treatment-Resistant Epileptic Patients

AI-Powered MRI Technology Improves Parkinson’s Diagnoses

Ultrasound

AI-Powered Lung Ultrasound Outperforms Human Experts in Tuberculosis Diagnosis

AI Identifies Heart Valve Disease from Common Imaging Test

Novel Imaging Method Enables Early Diagnosis and Treatment Monitoring of Type 2 Diabetes

Ultrasound-Based Microscopy Technique to Help Diagnose Small Vessel Diseases

Nuclear Medicine

Novel Radiolabeled Antibody Improves Diagnosis and Treatment of Solid Tumors

Novel PET Imaging Approach Offers Never-Before-Seen View of Neuroinflammation

Novel Radiotracer Identifies Biomarker for Triple-Negative Breast Cancer

Innovative PET Imaging Technique to Help Diagnose Neurodegeneration

General/Advanced Imaging

AI-Powered Imaging System Improves Lung Cancer Diagnosis

AI Model Significantly Enhances Low-Dose CT Capabilities

Ultra-Low Dose CT Aids Pneumonia Diagnosis in Immunocompromised Patients

AI Reduces CT Lung Cancer Screening Workload by Almost 80%

Imaging IT

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology

AI-Based Mammography Triage Software Helps Dramatically Improve Interpretation Process

Artificial Intelligence (AI) Program Accurately Predicts Lung Cancer Risk from CT Images

Industry News

GE HealthCare and NVIDIA Collaboration to Reimagine Diagnostic Imaging

Patient-Specific 3D-Printed Phantoms Transform CT Imaging

Siemens and Sectra Collaborate on Enhancing Radiology Workflows

Bracco Diagnostics and ColoWatch Partner to Expand Availability CRC Screening Tests Using Virtual Colonoscopy

MedImaging

Channels

Features

Partner Sites

Archive:

Click for LinkXpress Reader Inquiry Service
Enter code to receive information:

Where I can find code?

LinkXpress

Download Mobile App

Video Library

Radiotherapy for Brain Cancer May Be Improved by Blocking DNA Repair Processes

Latest Radiography News

Channels

MedImaging

Channels

Features

Partner Sites

Archive: