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Collaboration for Radiotherapy Microphere Drug Development for the Treatment of Primary and Secondary Liver Cancer

By MedImaging International staff writers
Posted on 31 Mar 2014

Sirtex Medical, Ltd. (Sydney, Australia) and Guerbet, SA (Villepinte, France) are entering into a clinical studies collaboration in primary and secondary (metastatic) liver cancer.

The aim of the collaboration is to examine how Sirtex’s SIR-Spheres microspheres and Guerbet’s Lipiodol Ultra Fluid may be combined or sequenced optimally—and additionally developed—for the treatment of patients with hepatocellular carcinoma, metastatic colorectal cancer, metastatic neuroendocrine tumors, and a variety of other primary and secondary liver cancers.

Sirtex’s chief executive officer, Gilman Wong commented that, “Sirtex’s and Guerbet’s shared vision is that one day, rather than being a terminal disease that patients unfortunately die from, liver cancer may be considered a chronic disease that patients can successfully live with. During my time at Sirtex, I have been fortunate to meet a number of patients who have survived their liver cancer for many years following treatment with SIR-Spheres microspheres. We hope through this clinical studies collaboration to make further gains for the benefit of the patients afflicted by liver cancer. Should the initial collaboration prove fruitful, future collaborations in R&D and marketing between our respective companies may be considered.”

Sirtex’s SIR-Spheres microspheres are utilized in selective internal radiation therapy (SIRT), also known as radioembolization, for the treatment of patients with inoperable liver tumors. SIR-Spheres microspheres have been shown in randomized controlled trials (RCTs) to optimize survival in patients with inoperable liver metastases from primary colorectal cancer. SIR-Spheres microspheres are now being assessed in six international, multicenter RCTs in metastatic colorectal cancer (mCRC) and hepatocellular carcinoma (HCC), which cumulatively will enroll over 2,100 patients. The first of these RCTs, the SIRFLOX study, finished patient enrolment in April 2013 and is expected to report its findings in early 2015.

Guerbet’s Lipiodol Ultra Fluid is used in traditional transarterial chemo-embolization (cTACE) procedures for the treatment of patients with inoperable liver tumors. cTACE has been published in over 100 clinical studies. Recently, cTACE has been established as the standard-of-care for the treatment of patients with intermediate stage HCC by three international clinical consensus guidelines in Europe, Japan, and the United States. These consensus guidelines universally recommend cTACE as the standard-of-care for patients with intermediate stage HCC.

Guerbet’s chief executive officer, Yves L’Epine, said, “We are excited about the potential of combining or sequencing our products to improve the efficacy of interventional radiology procedures in patients with unresectable hepatic tumors. Indeed, while Lipiodol and SIR-Spheres individually are well proven and widely used therapies in their own right, they have never been formally evaluated together or sequentially.”

Guerbet is a pharmaceutical group focused on contrast imaging development, offering of contrast products for X-ray and MRI and for interventional radiology, along with a range of injectors and related medical equipment to provide enhanced diagnosis and treatment of patients.

Related Links:
Sirtex Medical
Guerbet

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60 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

61 (149.01161193848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

62 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

63 (160.93254089355): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (649.92904663086): SELECT fid FROM jos_deeppockets WHERE id=294751488 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294751488 AND published='1' LIMIT 1

65 (72.956085205078): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

66 (!!!!! 1873.9700317383): select jos_twitters.link from jos_twitters where cat=10

67 (76.055526733398): select jos_facebook.link from jos_facebook where cat=10

68 (45.061111450195): select jos_google_plus.link from jos_google_plus where cat=10

69 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

70 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE id=294751488 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294751488 AND published='1' LIMIT 1

71 (52.928924560547): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

72 (560.04524230957): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294751488 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (351.90582275391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751488 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (63.896179199219): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (85.115432739258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294751488 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (41.961669921875): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751488 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (47.922134399414): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (!!!!! 3834.9628448486): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (150.91896057129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

107 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

108 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294751488 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (668.76411437988): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294751488 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (154.01840209961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

111 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

112 (506.16264343262): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294751488 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (497.10273742676): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294751488 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (!!!!! 5870.1038360596): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294751485 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (823.02093505859): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294751485 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (!!!!! 1137.0182037354): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (797.98698425293): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (576.01928710938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

119 (172.85346984863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

120 (194.07272338867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

121 (411.03363037109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

122 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

123 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

124 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

125 (50.783157348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

126 (397.92060852051): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

127 (!!!!! 66457.986831665): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

128 (728.13034057617): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294751488 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751488 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 22866.96434021): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (102.04315185547): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (53.882598876953): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (416.99409484863): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (597.95379638672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (411.03363037109): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (60.081481933594): SELECT name FROM jos_deeppockets WHERE id=211

142 (39.100646972656): SELECT name FROM jos_deeppockets WHERE id=211

143 (844.00177001953): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (688.07601928711): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

146 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

147 (!!!!! 41370.153427124): TRUNCATE TABLE jos_trademed_module

148 (802.04010009766): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294751488 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (165.22407531738): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294751488 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (910.99739074707): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (!!!!! 6633.0432891846): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (474.21455383301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

153 (980.13877868652): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

154 (!!!!! 4446.9833374023): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

155 (450.13427734375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

156 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

157 (102.99682617188): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294751488 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751488 AND type='deeppockets_item' AND published='1' LIMIT 1

158 (47.922134399414): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (43.153762817383): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (81.062316894531): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

161 (604.86793518066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

162 (535.96496582031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751488 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751488 AND published='1' LIMIT 1

163 (127.07710266113): select jos_twitters.link from jos_twitters where cat=10

164 (92.029571533203): select jos_facebook.link from jos_facebook where cat=10

165 (195.98007202148): select jos_google_plus.link from jos_google_plus where cat=10

166 (!!!!! 3190.0405883789): select jos_linkedin.link from jos_linkedin where cat=10

167 (863.07525634766): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

168 (!!!!! 1498.9376068115): insert into jos_banners_delta values (14615,'2025-08-19 01:13:11','216.73.216.0','view'),(14202,'2025-08-19 01:13:11','216.73.216.0','view'),(14203,'2025-08-19 01:13:11','216.73.216.0','view')

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