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CT Scans Predict Chemotherapy Response in Pancreatic Cancer Patients

By MedImaging International staff writers
Posted on 24 Mar 2014
Computed tomography (CT) scans routinely taken to guide the treatment of pancreatic cancer may also provide an important secondary benefit. According to new research, the scans also show how well chemotherapy will penetrate a tumor, predicting the effectiveness of treatment.

The research, published March 10, 2014, in the Journal of Clinical Investigation, is the first human study to address the issue of chemotherapy delivery to pancreatic tumors, a problem previously shown in animal studies. “We found that the distribution of intravenous dye used in CT scans is a surrogate for chemotherapy delivery in the tumor,” said Jason Fleming, MD, a professor of surgical oncology at the University of Texas MD Anderson Cancer Center (Houston, TX, USA), and corresponding author of the study. “Our results indicate that combining data from routine CT scans and using a mathematical formula developed by our team can predict response, guide patient treatment and lead to efforts to improve drug delivery.”

Pancreatic tumors contain disorganized or nonfunctional blood vessels, high proportions of fibrotic tissue and molecular variations that create barriers for a drug to reach its target. It's a disease with a poor prognosis and the American Cancer Society estimates more than 39,000 people will die in 2014 as a result.

“Chemotherapy is used every day, however we’ve done very little to demonstrate that the drug actually reaches the tumor efficiently,” Prof. Fleming said. “Results from our previous clinical trials at MD Anderson taught us that when chemotherapy kills most of a patient’s tumor, the patient has a better chance of being a long-term survivor.”

Researchers first enrolled 12 patients with primary pancreatic disease who would undergo a surgical resection. During surgery, each patient received an infusion of the chemotherapy drug gemcitabine. After surgery, the tumor DNA was analyzed for penetration of gemcitabine. Gemcitabine is delivered to tumor DNA primarily through a protein called the human equilibrative nucleoside transporter (hENT1). Previous studies have shown its expression varies in pancreatic tumors, linking the protein to drug response.

For patients in the study with dense, fibrotic tumors and not much hENT1 protein, the chemotherapy was delivered constantly but its uptake was minimal since the drug was not reaching cancer cells, according to Prof. Fleming. The researchers discovered that gemcitabine penetrated tumors at varying levels in the group of 12 patients and those with greater gemcitabine levels responded better to therapy and had improved outcomes. After seeing this disparity, the team examined past CT scans from another group of patients to compare how the drug reached tumor cells.

The researchers analyzed scans from 176 patients (12 who received gemcitabine infusion during surgery, 110 who received presurgical gemcitabine-based chemoradiation and 55 who received upfront surgery to remove the tumor). After reviewing the data, researchers noticed visual differences in tumors as a result of the CT contrast being absorbed differently. Based on these observations, Prof. Fleming and his colleagues began to question whether the intravenous contrast used for CT scans predicted the path and absorption of gemcitabine. It appeared that this hypothesis was correct.

By using models to measure factors that influence drug delivery, the researchers found resected tumors revealed up to six-fold differences in gemcitabine incorporation. “This work is showing that solid tumors are much more heterogeneous than we thought with respect to drug delivery,” Dr. Fleming said. “Going forward the implication is that molecular information from a biopsy of the tumor can be combined with data from a standard CT scan to place patients into categories that predict their response to therapy.”

Furthermore, Prof. Fleming noted that the trial implications are broad and could apply to other solid tumors. Researchers are beginning to look at existing drugs, such as losartan, a drug for high blood-pressure, as it could change the makeup of dense tumors, allowing better delivery of chemotherapy for patients who otherwise would have a poor response. “The nice thing is that we can measure the effect of these new and repurposed drugs by using intravenous contrast in CT scans as a surrogate, so we don’t have to commit a patient to receive a cancer drug until we know it improves the tumor characteristics,” he added.

Future research is needed, according to the investigators, to standardize this approach of matching patients’ tumors to the most effective drugs.

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84 (262.97569274902): SELECT show_live FROM jos_com_show_setting LIMIT 1
85 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1
86 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1
87 (961.7805480957): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294751375 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
88 (339.03121948242): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751375 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (653.98216247559): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (!!!!! 1528.0246734619): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (58.174133300781): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (!!!!! 2269.983291626): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (344.99168395996): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (528.81240844727): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (286.10229492188): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (209.80834960938): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (189.06593322754): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (925.06408691406): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (65.803527832031): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (!!!!! 3859.9967956543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
105 (!!!!! 3596.0674285889): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
106 (303.03001403809): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294751375 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (!!!!! 2642.1546936035): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294751375 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (645.16067504883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
109 (760.07843017578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
110 (!!!!! 1173.0194091797): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294751375 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (689.02969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294751375 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (863.07525634766): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (!!!!! 1967.9069519043): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (485.18180847168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
115 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
116 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
117 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
118 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
119 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
120 (567.91305541992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
121 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
122 (!!!!! 3201.961517334): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 64838.886260986): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (!!!!! 1676.082611084): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294751375 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751375 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 2368.9270019531): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (81.062316894531): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (289.2017364502): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (236.98806762695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (!!!!! 1176.8341064453): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (142.09747314453): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (166.89300537109): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (87.976455688477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (!!!!! 1813.8885498047): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (500.91743469238): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (!!!!! 2921.8196868896): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (640.869140625): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (300.88424682617): SELECT name FROM jos_deeppockets WHERE id=211
138 (47.922134399414): SELECT name FROM jos_deeppockets WHERE id=211
139 (794.1722869873): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (697.13592529297): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
142 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
143 (!!!!! 16897.916793823): TRUNCATE TABLE jos_trademed_module
144 (153.0647277832): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294751375 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (86.069107055664): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294751375 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (!!!!! 1164.9131774902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (!!!!! 8812.9043579102): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
149 (275.1350402832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
150 (!!!!! 3216.9818878174): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (!!!!! 4524.9462127686): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
152 (504.97055053711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
153 (529.05082702637): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294751375 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751375 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (130.89179992676): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
155 (200.98686218262): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
156 (!!!!! 1081.9435119629): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (466.10832214355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
158 (!!!!! 1317.9779052734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751375 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751375 AND published='1' LIMIT 1
159 (70.095062255859): select jos_twitters.link from jos_twitters where cat=10
160 (!!!!! 3451.1089324951): select jos_facebook.link from jos_facebook where cat=10
161 (553.84635925293): select jos_google_plus.link from jos_google_plus where cat=10
162 (48.87580871582): select jos_linkedin.link from jos_linkedin where cat=10
163 (402.92739868164): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
164 (!!!!! 1332.9982757568): insert into jos_banners_delta values (14615,'2025-08-12 15:42:46','216.73.216.186','view'),(14202,'2025-08-12 15:42:46','216.73.216.186','view'),(14203,'2025-08-12 15:42:46','216.73.216.186','view')