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Moderate Doses of Radiotherapy to Unaffected Breast May Prevent Second Breast Tumors

By MedImaging International staff writers
Posted on 05 Feb 2014
Image: A study conducted in lab mice suggests that breast cancer patients can drastically slash that risk through treatment with moderate doses of radiation to the unaffected breast at the same time that they receive radiation therapy to their affected breast (Photo courtesy of CUMC – Columbia University Medical Center).
Image: A study conducted in lab mice suggests that breast cancer patients can drastically slash that risk through treatment with moderate doses of radiation to the unaffected breast at the same time that they receive radiation therapy to their affected breast (Photo courtesy of CUMC – Columbia University Medical Center).
Breast cancer patients have a one in six possibility of developing breast cancer in the other breast. However, a study conducted in lab mice suggests that survivors can drastically slash that risk through treatment with moderate doses of radiation to the unaffected breast at the same time that they receive radiation therapy to their affected breast. The treatment, if it performs as well in humans as in lab mice, could prevent tens of thousands of second breast tumors.

The study was conducted by researchers from Columbia University Medical Center (CUMC; New York, NY, USA). “Over the past decades, we’ve had great success in treating breast cancer, and the 15-year survival rate is now 77%,” said study leader David J. Brenner, PhD, director of CUMC’s Center for Radiological Research and a professor of radiation biophysics. “Unfortunately, breast cancer survivors have a several times higher risk of developing cancer in their other breast, compared with healthy women of the same age.”

The study’s findings were published on December 20, 2013, in the online journal PLOS ONE. “While drugs such as tamoxifen and aromatase inhibitors can reduce the risk somewhat, at least for women with estrogen receptor-positive tumors, the long-term risks of a second breast cancer in the unaffected breast remain high. Because of these risks, approximately 10%–20% of breast cancer survivors in the US undergo prophylactic mastectomy of their other breast,” said Dr. Brenner.

The conception for prophylactic mammary irradiation (PMI) of the unaffected breast stems from earlier research of conventional whole-breast irradiation after lumpectomy. In that study, Dr. Brenner found that radiation is highly effective at destroying premalignant cells, not only in the quadrant of the breast where the first tumor was located, but additionally in the other three quadrants, where premalignant cells are typically though to be unconnected to the primary tumor. “So, we thought why can’t we treat the other breast with a moderate dose of radiation and kill any premalignant cells that could lead to second cancers?” said Dr. Brenner.

The crucial question was whether treating the breast with a moderate dose of radiation would in fact lower the overall risk of a second cancer. “We know that there will be a balance between radiation killing premalignant cells and radiation producing premalignant cells, but it seemed that using the right radiation dose would put the balance strongly toward lowering the cancer risk,” Dr. Brenner said.

This research project evaluated this therapy by performing PMI on transgenic mice that have a high risk of developing breast cancer, simulating the unaffected breast of a breast cancer survivor. Lead shields were placed so that one side of each mouse was shielded from the radiation. As projected, a moderate dose of radiation reduced the breast cancer risk in the treated side by a factor of approximately three. The researchers are now planning to assess PMI in a clinical trial.

If PMI demonstrates itself to be effective in patients, it could be used as an adjunct to tamoxifen or aromatase inhibitors for women with estrogen receptor-positive tumors and as a standalone therapy for those with estrogen-receptor negative tumors, who do not benefit from drug therapy. PMI, in ether instance, could be performed simultaneously with radiotherapy of the affected breast.

PMI could have a considerable clinical impact. At present, there are more than 2.6 million breast cancer survivors in the United States according to the American Cancer Society. “About 160,000 of these women are likely to develop cancer in their other breast,” said Dr. Brenner. “If PMI does, in fact, reduce the incidence of cancer by three-fold, as suggested by our results, about 100,000 cases of breast cancer could be prevented. Whether PMI would work for women with BRACA1 or BRACA2 mutations, which greatly increase one’s risk for breast and/or ovarian cancer, is another story. We don’t know that. Our next mouse study will look at the effects of PMI in BRACA1 mice.”

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82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
83 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
84 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
87 (44.107437133789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750569 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
88 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750569 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (!!!!! 4020.9293365479): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (!!!!! 1199.9607086182): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (684.02290344238): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (782.01293945312): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (113.96408081055): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (251.05476379395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
105 (!!!!! 4935.9798431396): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
106 (!!!!! 1888.9904022217): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750569 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (561.95259094238): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750569 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (!!!!! 2265.9301757812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
109 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
110 (!!!!! 1076.9367218018): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750569 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (409.12628173828): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750569 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (603.91426086426): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (391.00646972656): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
115 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
116 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
117 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
118 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
119 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
120 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
121 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
122 (300.16899108887): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 57967.901229858): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (550.0316619873): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750569 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750569 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 27127.981185913): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (68.187713623047): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (881.91032409668): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (232.93495178223): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (394.10591125488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (391.96014404297): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (148.05793762207): SELECT name FROM jos_deeppockets WHERE id=211
138 (40.054321289062): SELECT name FROM jos_deeppockets WHERE id=211
139 (571.96617126465): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (586.98654174805): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
142 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
143 (!!!!! 6099.9393463135): TRUNCATE TABLE jos_trademed_module
144 (149.96528625488): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750569 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750569 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (406.98051452637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (154.01840209961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
149 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
150 (!!!!! 1276.0162353516): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
152 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
153 (41.007995605469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750569 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750569 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
155 (28.848648071289): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
156 (29.087066650391): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (!!!!! 3421.0681915283): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
158 (60.796737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750569 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750569 AND published='1' LIMIT 1
159 (41.961669921875): select jos_twitters.link from jos_twitters where cat=10
160 (27.179718017578): select jos_facebook.link from jos_facebook where cat=10
161 (28.133392333984): select jos_google_plus.link from jos_google_plus where cat=10
162 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10
163 (356.91261291504): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
164 (!!!!! 3172.8744506836): insert into jos_banners_delta values (14615,'2025-08-13 09:29:49','216.73.216.186','view'),(14202,'2025-08-13 09:29:49','216.73.216.186','view'),(14203,'2025-08-13 09:29:49','216.73.216.186','view')