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Tomosynthesis Application More Sensitive Than Chest X-Ray Detecting Lung Nodules

By MedImaging International staff writers
Posted on 16 Jan 2014

Image: VolumeRAD offers improved detection and management of patients with lung nodules compared to conventional X-ray imaging of the chest (Photo courtesy of GE Healthcare).

A new tomosynthesis tool provides enhanced detection and management of lung cancer patients and is 7.5 times more sensitive than chest X-ray without decreased specificity in identifying patients who require follow-up.

GE Healthcare’s (Chalfont St. Giles, UK) new clinical application for its fixed radiographic system, VolumeRAD, offers improved detection and management of patients with lung nodules compared to conventional X-ray imaging of the chest. As the first thoracic radiographic tomosynthesis product with a specific indication, this application is designed to improve the detection of lung nodules and the subsequent management of patients.

VolumeRAD provides physicians with multiple high-resolution slice images of the anatomy of interest, including the chest, abdomen, extremities, and spine. This clinical feature is a method of acquiring a series of low-dose projection images during a single sweep of the X-ray tube over a limited angle.

“We are very excited by these results that clearly show the benefit of radiographic tomosynthesis vs conventional X-ray,” said Michelle Edler, general manager of radiology and fluoroscopy for GE’s detection and guidance solutions business. “Customers who use this technology will be able to detect more, and will benefit 360% greater sensitivity without any reduction in specificity, for lung nodules 3–20 mm in diameter. The potential of VolumeRAD as a high-quality, cost-effective, and low dose imaging alternative for lung nodule detection is massive.”

Dr Gautham Reddy, professor of radiology and vice chair for education and director of thoracic imaging in the department of radiology at the University of Washington (Seattle, USA) believes VolumeRAD can offer an intermediate solution for patient care. “Rather than simply getting a CT, we can do a VolumeRAD to verify whether it’s a nodule or not. [For] something that has low likelihood of being a nodule, VolumeRAD will probably exclude the possibility of a nodule and there won’t be as much radiation,” said Dr. Reddy. “That is one of the reasons why VolumeRAD would be helpful. We could get more information than with a [radiograph and] without as much radiation as a CT.”

VolumeRAD generates diagnostic chest images that enable radiologists to detect small lung nodules with superior sensitivity vs. posterior-anterior (PA) and left lateral views of the chest at minimal relative radiation level (< 0.1 mSv). This clinical feature is a way of acquiring a series of low-dose projection images during a single sweep of the X-ray tube over a limited angle.

As many as 60 images can be captured in approximately 10 seconds. These data are then used to generate images at the desired slice interval defined by the user, a huge dose and patient throughput benefit compared to linear tomography, which provides only one image from a similar tube sweep. Using CT-like algorithms, high-resolution thin slices are reconstructed and can be reviewed by the radiologist at a computer workstation as individual images or in a cine mode.

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62 (!!!!! 2023.9353179932): SELECT fid FROM jos_deeppockets WHERE id=294750187 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750187 AND published='1' LIMIT 1

63 (!!!!! 1652.9560089111): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (107.0499420166): select jos_twitters.link from jos_twitters where cat=10

65 (46.968460083008): select jos_facebook.link from jos_facebook where cat=10

66 (54.121017456055): select jos_google_plus.link from jos_google_plus where cat=10

67 (207.90100097656): select jos_linkedin.link from jos_linkedin where cat=10

68 (612.02049255371): SELECT fid FROM jos_deeppockets WHERE id=294750187 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750187 AND published='1' LIMIT 1

69 (173.09188842773): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (!!!!! 3463.9835357666): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750187 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (304.9373626709): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750187 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (92.983245849609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (102.04315185547): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (195.98007202148): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (!!!!! 1413.106918335): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (115.87142944336): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (72.002410888672): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750187 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (39.100646972656): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750187 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 1425.9815216064): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (!!!!! 2046.8235015869): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (821.11358642578): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (472.06878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 2304.0771484375): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (!!!!! 8030.891418457): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (!!!!! 7813.2152557373): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (!!!!! 8030.891418457): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 7862.8063201904): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (!!!!! 7889.0323638916): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (!!!!! 6564.1403198242): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (!!!!! 7783.1745147705): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (200.98686218262): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (!!!!! 6657.1235656738): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 4897.1176147461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

105 (!!!!! 6728.1723022461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

106 (!!!!! 6447.7920532227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750187 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 9435.8921051025): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750187 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 10949.850082397): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

109 (!!!!! 8026.123046875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

110 (294.92378234863): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750187 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (705.95741271973): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750187 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (833.03451538086): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (570.05882263184): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (198.8410949707): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

115 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

116 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

117 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

118 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

119 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

120 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

121 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

122 (563.14468383789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750187 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750187 AND type='deeppockets_item' AND published='1' LIMIT 1

123 (72.002410888672): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

124 (41.961669921875): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

125 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

126 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

127 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

128 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

129 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

130 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

131 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

132 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

133 (725.98457336426): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (442.9817199707): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (61.03515625): SELECT name FROM jos_deeppockets WHERE id=211

136 (36.954879760742): SELECT name FROM jos_deeppockets WHERE id=211

137 (946.99859619141): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (946.044921875): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (128.03077697754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

140 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

141 (!!!!! 1259.0885162354): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

143 (375.98609924316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

144 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

145 (!!!!! 1898.0503082275): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

146 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

147 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

148 (55.074691772461): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750187 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750187 AND type='deeppockets_item' AND published='1' LIMIT 1

149 (43.869018554688): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

150 (39.815902709961): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

151 (50.783157348633): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

152 (170.94612121582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

153 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750187 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750187 AND published='1' LIMIT 1

154 (72.002410888672): select jos_twitters.link from jos_twitters where cat=10

155 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

156 (46.968460083008): select jos_google_plus.link from jos_google_plus where cat=10

157 (39.815902709961): select jos_linkedin.link from jos_linkedin where cat=10

158 (413.89465332031): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

159 (!!!!! 2161.979675293): insert into jos_banners_delta values (14615,'2025-08-19 02:37:00','216.73.216.0','view'),(14202,'2025-08-19 02:37:00','216.73.216.0','view'),(14203,'2025-08-19 02:37:00','216.73.216.0','view')

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