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Computer-Controlled Couch Used to Direct Radiotherapy to Tumors

By MedImaging International staff writers
Posted on 16 Jan 2014

Swiveling patients around on a computer-controlled, rotating table could deliver high doses of radiotherapy to tumors more rapidly than current technology, while sparing vulnerable organs such as the eyes, heart, brain, and bowel.

Sophisticated computer modelling has been devised to slowly move the table, known as a couch, and a radiation source in three dimensions to direct radiation right to the patient’s tumor. A radiotherapy table currently can be angled during treatment, but there is no way to synchronize its rotation with a moving radiation beam. However, with some alterations, an upgraded system could move both the patient and the beam while reducing the radiation dose of healthy tissue.

A team of researchers from the Institute of Cancer Research, London (ICR; UK) and the Royal Marsden NHS (National Health Service) Foundation Trust (London, UK) modelled the effectiveness of the technique using data from four patients with different cancers close to major organs and found it could substantially cut the amount of radiation delivered to healthy tissue. The study was published November 7, 2013, in the journal Physics in Medicine and Biology.

In breast cancer, the average radiation dose to the heart could be reduced by 53% compared with radiotherapy without the new technique. In a patient with a brain tumor, maximum calculated doses to the left and right eye lenses decreased by 61% and 77% respectively, and by 37% and 40% to the left and right eyes, respectively.

The technique could slash the average dose a prostate cancer patient’s bowel is exposed to by 15%. Patients with advanced prostate cancer, where the pelvic nodes are also treated, could see the volume of their bowel exposed to radiation lowered by as much as 45%. This next-generation radiotherapy technique, known as dynamic couch rotation volumetric-modulated arc therapy (DCR-VMAT), would use a beam of radiation, which would move around the patient, while also moving the patient table simultaneously. Clinicians could control the angle of the beam, the dose rate and the shape of the beam, and limit the radiation dose to the patient’s healthy organs.

Because the technique is so new, little research has been conducted about how to coordinate the patient’s movement with the radiation source to minimize organ exposure while treating tumors in different parts of the body. This is the first study using sophisticated computer modelling to directly optimize the technique.

Researchers at the ICR and The Royal Marsden used computer modelling of the path of the radiation beam to produce maps showing the amount of radiation from the moving source that intersected with healthy organs near the patient’s tumors. They cross-referenced this with every possible orientation of the table in relation to the beam to calculate how to move the patient during DCR-VMAT to minimize the radiation dose to healthy organs.

Study leader Dr. James Bedford, lead clinical research physicist in the joint department of physics at the Institute of Cancer Research, London and The Royal Marsden NHS Foundation Trust, said, “Radiotherapy continues to improve as new ways of directing radiation to the tumor while sparing the critical structures are found. The outcome of radiotherapy depends very much on the type of cancer and where it is located in the body. This technique allows us to maximize the dose to the tumor while steering the radiation beam around the sensitive normal tissues. It will be of particular value for patients whose tumors are located near to radiation-sensitive organs.

“Although other high-tech radiotherapy systems exist, they are only available at a few sites around the UK, and the time taken to treat the patient is considerable. The advantage of our proposed system is that it improves on radiotherapy machines already widely available—it’s the natural progression for these devices. The new technique could provide precision radiotherapy that would be easier to implement in every radiotherapy facility in the country. Furthermore, treatment would only take a few minutes, which is more comfortable for the patient and improves accuracy.”

Prof. Alan Ashworth, chief executive of the Institute of Cancer Research, London, said, “Research into physics has played an important but largely unheralded role in advancing cancer treatment, with around 40% of cancer survivors having received radiotherapy. Our physicists are developing cutting-edge techniques to deliver doses of radiation to tumors more precisely. This work could substantially reduce the amount of harmful radiation patients' healthy organs are exposed to, allowing us to hit the cancer with higher and more effective doses of treatment.”

Dr. Imogen Locke, lead for clinical oncology at the Royal Marsden, said, “This research has the exciting potential to translate into significant clinical benefit for patients by reducing some of the long-term effects of radiotherapy on healthy tissue. Delivering radiotherapy using advanced rotational techniques also allows treatment to be targeted more accurately and delivered more rapidly.”

Related Links:
Institute of Cancer Research, London Institute of Cancer Research, London
Royal Marsden NHS Foundation Trust

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58 (138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

59 (!!!!! 2656.9366455078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

60 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

61 (154.01840209961): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (805.85479736328): SELECT fid FROM jos_deeppockets WHERE id=294750186 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750186 AND published='1' LIMIT 1

63 (554.08477783203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (87.976455688477): select jos_twitters.link from jos_twitters where cat=10

65 (46.014785766602): select jos_facebook.link from jos_facebook where cat=10

66 (47.206878662109): select jos_google_plus.link from jos_google_plus where cat=10

67 (43.153762817383): select jos_linkedin.link from jos_linkedin where cat=10

68 (76.055526733398): SELECT fid FROM jos_deeppockets WHERE id=294750186 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750186 AND published='1' LIMIT 1

69 (56.028366088867): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (473.97613525391): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (462.05520629883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 5311.9659423828): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (128.98445129395): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (106.0962677002): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (70.095062255859): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 1540.8992767334): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (716.9246673584): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 3839.9696350098): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (131.13021850586): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (70.095062255859): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (170.94612121582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

105 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

106 (113.01040649414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (825.88195800781): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 2341.9857025146): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

109 (154.01840209961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

110 (363.11149597168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1317.024230957): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (760.79368591309): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (621.08039855957): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (125.88500976562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

115 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

116 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

117 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

118 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

119 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

120 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

121 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

122 (!!!!! 2665.9965515137): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 58648.824691772): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (788.92707824707): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750186 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750186 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 24520.874023438): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (80.108642578125): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (285.86387634277): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (248.90899658203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (149.96528625488): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (210.04676818848): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 5178.9283752441): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (716.9246673584): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 2635.0021362305): SELECT name FROM jos_deeppockets WHERE id=211

138 (135.18333435059): SELECT name FROM jos_deeppockets WHERE id=211

139 (962.0189666748): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (818.96781921387): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (138.0443572998): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

142 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

143 (!!!!! 17693.996429443): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 2650.0225067139): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (354.76684570312): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1339.9124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

149 (!!!!! 2496.9577789307): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

150 (!!!!! 3825.9029388428): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (121.11663818359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

152 (473.97613525391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

153 (!!!!! 2281.9042205811): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750186 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750186 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (93.936920166016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (49.114227294922): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (!!!!! 1636.9819641113): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (216.00723266602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

158 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750186 AND published='1' LIMIT 1

159 (106.0962677002): select jos_twitters.link from jos_twitters where cat=10

160 (46.014785766602): select jos_facebook.link from jos_facebook where cat=10

161 (42.915344238281): select jos_google_plus.link from jos_google_plus where cat=10

162 (41.007995605469): select jos_linkedin.link from jos_linkedin where cat=10

163 (433.92181396484): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1489.8777008057): insert into jos_banners_delta values (14615,'2025-08-19 02:39:03','216.73.216.0','view'),(14202,'2025-08-19 02:39:03','216.73.216.0','view'),(14203,'2025-08-19 02:39:03','216.73.216.0','view')

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