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New Nanomaterial Promises Enhanced Detection and Treatment of Breast Cancer

By MedImaging International staff writers
Posted on 07 Jan 2014

Image: Muonium [an exotic atom made up of an antimuon and an electron] trapped inside a buckyball. Muons provide a complementary probe to neutrons, particularly in the areas of magnetism, superconductivity, and charge transport (Photo courtesy of ISIS).

A collaboration of scientists from the United Kingdom, Denmark, Brazil, and Germany are devising new detection and treatment technology for breast cancer patients.

The study’s findings were published December 2013 in the Journal of Alloys and Compounds. Current diagnostic methods such as mammograms can only detect between 65% and 95% of tumors, and developing better ways of detection is of prime urgency. If not detected and treated early enough, breast cancer can spread to other areas of the body, increasing the probability that the disease will become lethal.

The team of scientists has been using the Polaris instrument at the ISIS pulsed neutron and muon source at the Rutherford Appleton Laboratory (Harwell Oxford, UK) to develop a new bio-nanocomposite that they hope will eventually lead to earlier detection, and more successful treatment, of breast cancer. The new substance exploits the fact that cancer cells attract a molecule called hydroxyapatite, which is a component of bones. The researchers are developing magnetic nanoparticles coated with a biocompatible polymer that includes hydroxyapatite nanocrystals. When administered into the body, these nanoparticles should travel right to cancer cells, and once they do, they make it much easier to detect the tumor on an MRI scan.

Not only do the nanoparticles help to identify tumors, but they may also help to block the metastasis to other areas of the body, as hydroxyapatite is known to suppress that facet of tumor activity.

The next phase of study is to incorporate antitumor agents into the nanoparticles. The magnetic nature of the nanoparticles means that they can be directed to the site of the tumor by using magnets outside of the body. If antitumor drugs can be added to the nanoparticles, then they can be used to deliver the treatment directly to the tumor, optimizing the effectiveness of the treatment and reducing the risk of harmful side effects--imagine a fleet of tiny drones, delivering anticancer weapons right where they are needed.

This research is at a very early stage, and far more study is required, according to the scientists, before it can be developed into a treatment option.

ISIS generates beams of neutrons and muons that allow scientists to study materials at the atomic level using a suite of instruments, frequently described as super-microscopes. It supports a national and international community of more than 2,000 scientists who use neutrons and muons for research in physics, chemistry, materials science, geology, engineering, and biology.

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66 (982.99980163574): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

67 (454.18739318848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

68 (!!!!! 15033.960342407): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

69 (522.13668823242): SELECT fid FROM jos_deeppockets WHERE id=294750016 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750016 AND published='1' LIMIT 1

70 (!!!!! 6764.8887634277): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

71 (102.99682617188): select jos_twitters.link from jos_twitters where cat=10

72 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

73 (32.901763916016): select jos_google_plus.link from jos_google_plus where cat=10

74 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

75 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE id=294750016 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750016 AND published='1' LIMIT 1

76 (33.140182495117): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

77 (339.03121948242): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750016 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

78 (194.07272338867): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750016 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

79 (43.869018554688): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

80 (!!!!! 1568.7942504883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (483.98971557617): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (554.08477783203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (448.94218444824): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (!!!!! 2387.0468139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (278.94973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (127.07710266113): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (!!!!! 2216.100692749): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (759.12475585938): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750016 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

95 (58.889389038086): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750016 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

96 (199.0795135498): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

97 (!!!!! 9013.8912200928): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (897.16911315918): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (647.06802368164): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (594.8543548584): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (60.796737670898): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (967.02575683594): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (639.91546630859): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (650.16746520996): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (!!!!! 3282.0701599121): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (70.095062255859): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (465.15464782715): SELECT show_live FROM jos_com_show_setting LIMIT 1

109 (413.89465332031): SELECT show_live FROM jos_com_show_setting LIMIT 1

110 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

111 (!!!!! 1786.9472503662): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

112 (455.14106750488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

113 (!!!!! 1096.0102081299): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750016 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (!!!!! 1096.9638824463): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750016 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (!!!!! 11191.129684448): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

116 (!!!!! 2158.8802337646): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

117 (860.92948913574): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750016 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

118 (395.77484130859): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750016 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

119 (!!!!! 1029.9682617188): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

120 (!!!!! 1202.1064758301): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

121 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

122 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

123 (!!!!! 1220.9415435791): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

124 (!!!!! 1652.0023345947): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

125 (!!!!! 1393.0797576904): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

126 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

127 (!!!!! 1353.9791107178): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

128 (371.93298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

129 (201.94053649902): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

130 (!!!!! 57062.864303589): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

131 (941.99180603027): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750016 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750016 AND type='deeppockets_item' AND published='1' LIMIT 1

132 (56.028366088867): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

133 (36.954879760742): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

134 (986.09924316406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

135 (380.03921508789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

136 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

137 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

138 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

139 (970.84045410156): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

140 (437.97492980957): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

141 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

142 (675.91667175293): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

143 (726.93824768066): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

144 (!!!!! 1551.8665313721): SELECT name FROM jos_deeppockets WHERE id=211

145 (60.081481933594): SELECT name FROM jos_deeppockets WHERE id=211

146 (683.06922912598): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

147 (733.1371307373): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

148 (730.99136352539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

149 (933.88557434082): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

150 (!!!!! 17572.164535522): TRUNCATE TABLE jos_trademed_module

151 (!!!!! 5032.0625305176): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750016 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

152 (!!!!! 2749.2046356201): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750016 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

153 (862.12158203125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

154 (187.15858459473): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

155 (454.90264892578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

156 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

157 (!!!!! 5944.0135955811): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

158 (651.83639526367): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

159 (155.92575073242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

160 (478.02925109863): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750016 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750016 AND type='deeppockets_item' AND published='1' LIMIT 1

161 (137.8059387207): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

162 (36.954879760742): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

163 (645.16067504883): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

164 (!!!!! 4707.8132629395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

165 (!!!!! 3067.9702758789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750016 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750016 AND published='1' LIMIT 1

166 (272.98927307129): select jos_twitters.link from jos_twitters where cat=10

167 (128.03077697754): select jos_facebook.link from jos_facebook where cat=10

168 (32.901763916016): select jos_google_plus.link from jos_google_plus where cat=10

169 (134.94491577148): select jos_linkedin.link from jos_linkedin where cat=10

170 (661.13471984863): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

171 (!!!!! 1070.0225830078): insert into jos_banners_delta values (14615,'2025-08-03 03:15:35','216.73.216.210','view'),(14202,'2025-08-03 03:15:35','216.73.216.210','view'),(14203,'2025-08-03 03:15:35','216.73.216.210','view')

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