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Some Older Breast Cancer Patients May Not Need Radiotherapy

By MedImaging International staff writers
Posted on 06 Jan 2014

For women age 65 or older who receive hormone therapy after breast-conserving surgery for hormone receptor-positive, axillary node-negative breast cancer, omission of radiotherapy is a viable option, according to new findings

“Radiotherapy has been known to reduce the risk of breast cancer recurrence three- to fourfold. However, what our trial has shown is that although this is still the case, the proportion of women who will actually have a recurrence without radiotherapy is very small [less than 5%], five years after treatment,” said Ian Kunkler, FRCR, professor of clinical oncology at the Edinburgh Cancer Research Center at the University of Edinburgh (UK).

The PRIME (Postoperative Radiotherapy In Minimum-risk Elderly) 2 Trial findings were presented at the 2013 San Antonio Breast Cancer Symposium (TX, USA) held during December 10–14, 2013. “We have identified a subgroup of older patients at sufficiently low risk of recurrence for whom omission of postoperative radiotherapy after breast-conserving surgery and adjuvant endocrine therapy is a reasonable option. What this study shows is that for every 100 women (from our selected population) treated with radiotherapy, one will have a recurrence anyway, four will have a recurrence prevented, but 95 will have had unnecessary treatment,” said Dr. Kunkler. “Once a patient has had radiotherapy, they are unable to have it again on the same breast. Had these women not had radiotherapy, they would have been able to have minor surgery and radiotherapy following a recurrence. Besides, radiotherapy carries its own health risks, particularly in the elderly, as well as the inconvenience of travel for daily treatment for three or four weeks. Allowing us to defer radiotherapy in this group of patients until a recurrence occurs will be of benefit to the patient and to the health service.”

PRIME 2 is an international, phase III, randomized, controlled trial that set out to address the issue of whether whole-breast radiotherapy can be omitted in carefully defined groups of older patients receiving applicable therapy. The primary endpoint of this trial is recurrence of breast cancer in the same breast, known as ipsilateral breast tumor recurrence (IBTR).

The investigators discovered that at five years, 1.3% of patients who received radiotherapy had IBTR, and 4.1% of patients who did not receive radiotherapy had IBTR. Between 2003 and 2009, 1,326 patients were enrolled in the trial; 658 patients were randomly assigned to receive radiotherapy and 668 did not receive radiotherapy. All participants were age 65 or older; had hormone-positive, low-grade breast cancer; did not have the disease in lymph nodes adjacent to the breast (axillary node-negative); did not have metastasis; had cancer-free breast tissue margins where tumor was surgically removed; and received hormone therapy.

The investigators found that at five years, between patients who received radiotherapy and those who did not, there was no significant difference in overall survival (97% vs. 96.4%); regional recurrence (0.5% vs. 0.8%); or breast cancer in the opposite breast (0.5% vs. 0.7%). The difference in breast cancer-free survival between those receiving and not receiving radiotherapy (98.5% vs. 96.4%), however, was statistically significant. “Our results are likely to lead to the consideration of omission of postoperative radiotherapy in patients meeting the eligibility criteria for the trial,” Dr. Kunkler said.

Related Links:
University of Edinburgh Cancer Research Center

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61 (!!!!! 3554.8210144043): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (555.99212646484): SELECT fid FROM jos_deeppockets WHERE id=294749995 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294749995 AND published='1' LIMIT 1

63 (281.81076049805): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (50.067901611328): select jos_twitters.link from jos_twitters where cat=10

65 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

66 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

68 (57.93571472168): SELECT fid FROM jos_deeppockets WHERE id=294749995 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294749995 AND published='1' LIMIT 1

69 (43.153762817383): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (260.1146697998): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (227.92816162109): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1559.9727630615): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (69.856643676758): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (86.069107055664): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (29.802322387695): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (34.093856811523): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (91.075897216797): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (63.180923461914): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1642.9424285889): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

105 (!!!!! 2866.0297393799): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

106 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (597.95379638672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 5053.9970397949): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

109 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

110 (!!!!! 3694.0574645996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294749995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (617.98095703125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294749995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (619.17304992676): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (488.0428314209): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

115 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

116 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

117 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

118 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

119 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

120 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

121 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

122 (319.00405883789): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 50908.088684082): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (658.98895263672): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749995 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749995 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 16440.868377686): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (157.83309936523): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (88.930130004883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (48.87580871582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (86.069107055664): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (404.11949157715): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (472.06878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (280.14183044434): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (176.90658569336): SELECT name FROM jos_deeppockets WHERE id=211

138 (41.961669921875): SELECT name FROM jos_deeppockets WHERE id=211

139 (597.95379638672): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (458.0020904541): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

142 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

143 (!!!!! 12180.089950562): TRUNCATE TABLE jos_trademed_module

144 (109.91096496582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (985.86082458496): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (681.87713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 2429.0084838867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

149 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

150 (!!!!! 6701.9462585449): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (88.214874267578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

152 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

153 (!!!!! 3564.1193389893): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749995 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749995 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (119.92454528809): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (36.954879760742): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 3315.9255981445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

158 (!!!!! 3973.0072021484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749995 AND published='1' LIMIT 1

159 (43.153762817383): select jos_twitters.link from jos_twitters where cat=10

160 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

161 (29.802322387695): select jos_google_plus.link from jos_google_plus where cat=10

162 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

163 (364.06517028809): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1018.0473327637): insert into jos_banners_delta values (14615,'2025-08-12 17:51:28','216.73.216.186','view'),(14202,'2025-08-12 17:51:28','216.73.216.186','view'),(14203,'2025-08-12 17:51:28','216.73.216.186','view')

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