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For Patients with Desmoid-Type Fibromatosis, Moderate Dose Radiotherapy Proves Effective

By MedImaging International staff writers
Posted on 03 Sep 2013

A new study for patients with inoperable desmoid-type fibromatosis has shown that moderate dose radiotherapy is an effective treatment for patients with this rare type of tumor. The data revealed that response after radiation therapy is gradual, and that continuing regression is seen even after three years.

The phase II EORTC (European Organization for Research and Treatment of Cancer; Brussels, Belgium) trial study’s findings were first published online July 17, 2013, in the journal Annals of Oncology. Dr. Ronald B. Keus, from the Arnhem Radiotherapy Institute (The Netherlands), and coordinator of the study, stated, “Although one should still be cautious to use radiotherapy in these young patients, it is important to have shown sound proof of efficacy of radiotherapy in this disease.”

A rare form of cancer, desmoid-type fibromatosis is a soft tissue neoplasm that can recur frequently but is not metastatic. The survival prognosis for patients with this disease is good, but due to the frequent recurrences, the consequences of treatment can lower functional outcomes and quality of life. Desmoid-type fibromatosis strikes most frequently in individuals between 30 and 40 years of age.

The first line of treatment for patients with desmoid-type fibromatosis is typically surgery, so the phase 2 EORTC 62991-22998 trial was done to determine if moderate doses of radiotherapy might improve outcome for patients with inoperable and progressive disease or in cases of expected extensive and mutilating surgery. The primary endpoint was local control rate at three years, and secondary endpoints were objective tumor response, acute toxicity, and late toxicity.

Dr. Winette van der Graaf, from the Radboud University Medical Center (Nijmegen, The Netherlands), and chair of the EORTC Soft Tissue and Bone Sarcoma Group, said, “Desmoid fibromatosis remains a challenge for surgeons, radiotherapists and medical oncologists. This study has generated valuable information about radiotherapy as an option for patients with desmoid-type fibromatosis which can be discussed at future multidisciplinary sarcoma tumor boards.”

The EORTC trial 62991-22998 enrolled 44 patients, 27 females and 17 males, between 2001 and 2008 in twelve sites located in five countries: Germany, Belgium, Poland, The Netherlands, and the United Kingdom. The median age was 39.5 years, and the key tumor areas included trunk 15 (34.1%) and extremities 27 (61.3%). At a median follow-up of 4.8 years, the three-year local control rate was 81.5%.

The best overall response during the first three years was complete response in six patients (13.6%), partial response in 16 patients (36.4%), stable disease in 18 patients (40.9%), and progressive disease in three patients (6.8%). One patient (2.3%) was non-evaluable. After three years two patients improved to total response and one patient improved to partial response. Five patients developed new lesions during the study, and 10 patients experienced mild edema as a late toxicity. Acute grade 3 side effects were limited to mucosal membranes, skin, and pain.

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63 (!!!!! 7755.9947967529): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (!!!!! 7583.1413269043): select jos_twitters.link from jos_twitters where cat=10

65 (!!!!! 3922.9393005371): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 7946.0144042969): select jos_google_plus.link from jos_google_plus where cat=10

67 (291.10908508301): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 2290.9641265869): SELECT fid FROM jos_deeppockets WHERE id=294748053 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294748053 AND published='1' LIMIT 1

69 (319.9577331543): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (!!!!! 4716.8731689453): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294748053 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (360.01205444336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294748053 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (81.062316894531): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (77.962875366211): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (57.220458984375): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (52.213668823242): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (142.09747314453): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (191.92695617676): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 1808.8817596436): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (172.13821411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (447.98851013184): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (442.9817199707): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (504.97055053711): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (164.03198242188): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294748053 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (72.002410888672): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294748053 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (49.114227294922): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (755.07164001465): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (226.02081298828): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 3489.9711608887): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (894.06967163086): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (304.9373626709): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (145.91217041016): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (185.96649169922): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (97.036361694336): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (300.88424682617): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (645.87593078613): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (!!!!! 1323.938369751): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 1108.1695556641): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (739.09759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 5354.8812866211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

105 (815.86837768555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

106 (!!!!! 1616.0011291504): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294748053 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 1224.0409851074): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294748053 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1281.0230255127): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

109 (!!!!! 7376.9092559814): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

110 (727.89192199707): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294748053 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (885.96343994141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294748053 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 13937.950134277): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 9779.2148590088): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 12133.121490479): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

115 (!!!!! 4934.0724945068): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

116 (!!!!! 1714.9448394775): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

117 (244.140625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

118 (!!!!! 1346.8265533447): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

119 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

120 (302.07633972168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

121 (!!!!! 1727.819442749): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

122 (!!!!! 5003.9291381836): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 123917.81806946): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1891.8514251709): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294748053 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294748053 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 39853.096008301): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 37487.030029297): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 3711.9388580322): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (340.93856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (360.01205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (72.956085205078): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (878.09562683105): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (446.79641723633): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 4441.9765472412): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (774.86038208008): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 2062.7975463867): SELECT name FROM jos_deeppockets WHERE id=211

138 (!!!!! 2144.0982818604): SELECT name FROM jos_deeppockets WHERE id=211

139 (!!!!! 3026.008605957): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 4712.8200531006): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 2611.1602783203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

142 (651.12113952637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

143 (!!!!! 29942.035675049): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1926.8989562988): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294748053 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 2627.8495788574): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294748053 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (997.06649780273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (349.99847412109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (462.05520629883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

149 (216.96090698242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

150 (!!!!! 5920.8869934082): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (143.05114746094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

152 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

153 (!!!!! 1119.1368103027): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294748053 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294748053 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (!!!!! 1125.0972747803): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (136.13700866699): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (704.05006408691): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (751.97219848633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

158 (170.94612121582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748053 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748053 AND published='1' LIMIT 1

159 (188.11225891113): select jos_twitters.link from jos_twitters where cat=10

160 (46.968460083008): select jos_facebook.link from jos_facebook where cat=10

161 (135.89859008789): select jos_google_plus.link from jos_google_plus where cat=10

162 (140.90538024902): select jos_linkedin.link from jos_linkedin where cat=10

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