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3D Breast Tomosynthesis Provides Superior Sensitivity for Architectural Distortions and Masses

By MedImaging International staff writers
Posted on 24 Jul 2013

Image: The SenoClaire breast tomosynthesis system is a three-dimensional (3D) imaging technology that uses a low-dose short X-ray sweep around the compressed breast with only nine exposures (Photo courtesy of GE).

A new breast tomosynthesis system is a three-dimensional (3D) imaging technology that uses a low-dose short X-ray sweep around the compressed breast with only nine exposures. The new system provides very high sensitivity for architectural distortions and masses, providing more clinical effectiveness while delivering the same amount of radiation dose as a digital mammography acquisition of the same view.

The SenoClaire system, powered by ASiR (adaptive statistical iterative reconstruction) digital breast tomosynthesis (DBT) and developed by GE Healthcare (Chalfont St, Giles, UK), enhances mammographic specificity by improving lesion margin visibility. Because of its low dose and non-inferior clinical accuracy, SenoClaire has the potential to replace digital mammography exams in screening at half the dose to help in the identification of breast cancer. An additional craniocaudal (CC) view, as part of the learning curve process may be considered along with the 3D mediolateral-oblique (MLO) view, which will help radiologists become more comfortable with reviewing only the 3D MLO sequence in the near future.

SenoClaire enables optimized characterization of malignant and benign findings by providing a 3D MLO view that has excellent detection for architectural distortions and masses when compared with 2D full field digital mammography (FFDM). Clinical findings have demonstrated that the recall rate after a 3D MLO examination is lower than the recall rate after a 2D FFDM exam.

The detector offers high detective quantum efficiency (DQE) at a low dose for visualizing microcalcifications without binning, a process that regroups pixels for faster readout speeds and improved signal-to-noise ratios, but with reduced image quality. Step-and-shoot tube motion maintains microcalcification sharpness and avoids image blur, because the tube makes a complete stop for each of the nine exposures. This provides higher peak contrast for microcalcifications than conventional continuous tube motion.

An antiscatter solution designed for tomosynthesis, the SenoClaire grid in 3D reduces scattered radiation and improves detectability in 3D for breasts of above-average thickness, while preserving dose and performance. The system uses ASiRDBT, an iterative reconstruction algorithm that generates FFDM-like images and positively impacts microcalcification conspicuity versus the conventional filtered back projection (FBP) algorithm.

Because GE builds the Senographe with upgradability in mind, the system can easily be expanded as the department needs and capabilities grow. SenoClaire 3D breast tomosynthesis, stereotaxy, or SenoBright contrast-enhanced spectral mammography are fully compatible with any Senographe Essential and Senographe Care. The system’s images are compatible with major picture archiving and communication system (PACS) providers (with local variability), allowing integration into an existing setting, making optimal use of the investment.

With the IDI MammoWorkstation, radiologists can easily navigate through the DBT dataset using customized 2D/3D hanging protocols and specific ergonomic features: clear-cut visual identification of all series of tomosynthesis planes and slabs; dedicated tools to review tomosynthesis data sets: cine loop, bookmarks, breast localizer, breast height ruler; and V-Preview reconstructed images from tomosynthesis.

A requirement of dose performance entails that patient X-ray dose is kept as low as reasonably acceptable. A single MLO view of SenoClaire, powered by ASiRDBT, provides clinical non-inferiority when compared to two-view digital mammography. The system provides half the dose, with one single compression. SenoClaire’s ASiRDBT iterative reconstruction algorithm provides FFDM-like images and effectively impacts microcalcification conspicuity versus the conventional filtered back projection (FBP) algorithm.

SenoClaire’s 3D MLO sequence requires only nine exposures with an even distribution of the dose. The SenoClaire grid in 3D reduces scattered radiation and improves detectability in 3D for breasts of above-average thickness, while preserving dose and performance.

The dual-track X-ray tube (Mo/Rh) delivers optimal X-ray spectra to penetrate the breast based on breast density and compressed breast thickness. Automatic optimization of parameters (AOP) helps in the identification of the densest breast regions and automatically selects the correct anode, filter, kV, and mAs to ensure repeatable image quality at optimized radiation dose.

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54 (!!!!! 3334.0454101562): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

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56 (!!!!! 1080.0361633301): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294747408 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 11673.927307129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

58 (!!!!! 1684.1888427734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

59 (!!!!! 2609.9681854248): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

60 (267.98248291016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

61 (!!!!! 3928.8997650146): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (974.17831420898): SELECT fid FROM jos_deeppockets WHERE id=294747408 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294747408 AND published='1' LIMIT 1

63 (92.983245849609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (563.14468383789): select jos_twitters.link from jos_twitters where cat=10

65 (148.05793762207): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 1282.9303741455): select jos_google_plus.link from jos_google_plus where cat=10

67 (132.08389282227): select jos_linkedin.link from jos_linkedin where cat=10

68 (56.982040405273): SELECT fid FROM jos_deeppockets WHERE id=294747408 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294747408 AND published='1' LIMIT 1

69 (261.06834411621): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (688.07601928711): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294747408 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 1844.8829650879): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294747408 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1457.2143554688): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 2089.9772644043): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (123.02398681641): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (110.86463928223): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (92.983245849609): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (120.16296386719): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (121.11663818359): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (784.87396240234): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (643.01490783691): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (107.0499420166): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (279.90341186523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294747408 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (541.92543029785): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294747408 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (366.9261932373): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (69.856643676758): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (68.187713623047): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (519.99092102051): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (277.99606323242): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (!!!!! 1536.1309051514): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (!!!!! 2722.9785919189): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (912.90473937988): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

105 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

106 (56.982040405273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294747408 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294747408 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (164.98565673828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

109 (383.13865661621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

110 (215.05355834961): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294747408 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (407.93418884277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294747408 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (840.90232849121): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (540.97175598145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (190.97328186035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

115 (100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

116 (135.18333435059): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

117 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

118 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

119 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

120 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

121 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

122 (701.1890411377): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294747408 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294747408 AND type='deeppockets_item' AND published='1' LIMIT 1

123 (!!!!! 58398.962020874): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

124 (!!!!! 3542.9000854492): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

125 (283.00285339355): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

126 (430.82237243652): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

127 (77.009201049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

128 (!!!!! 1152.9922485352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

129 (!!!!! 1970.0527191162): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

130 (447.98851013184): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

131 (375.98609924316): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

132 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

133 (!!!!! 7467.0314788818): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (!!!!! 7861.852645874): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (!!!!! 7824.182510376): SELECT name FROM jos_deeppockets WHERE id=211

136 (!!!!! 7980.1082611084): SELECT name FROM jos_deeppockets WHERE id=211

137 (!!!!! 7918.119430542): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (!!!!! 4692.0776367188): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (!!!!! 11488.914489746): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

140 (!!!!! 7686.8534088135): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

141 (!!!!! 3901.9584655762): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (257.96890258789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

143 (!!!!! 2466.9170379639): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

144 (!!!!! 1327.9914855957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

145 (!!!!! 5064.0106201172): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

146 (!!!!! 2313.1370544434): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

147 (!!!!! 1348.9723205566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

148 (!!!!! 4710.9127044678): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294747408 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294747408 AND type='deeppockets_item' AND published='1' LIMIT 1

149 (!!!!! 1329.8988342285): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

150 (77.962875366211): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

151 (818.96781921387): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

152 (!!!!! 4292.9649353027): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

153 (380.9928894043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747408 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747408 AND published='1' LIMIT 1

154 (!!!!! 2032.995223999): select jos_twitters.link from jos_twitters where cat=10

155 (72.002410888672): select jos_facebook.link from jos_facebook where cat=10

156 (59.843063354492): select jos_google_plus.link from jos_google_plus where cat=10

157 (51.021575927734): select jos_linkedin.link from jos_linkedin where cat=10

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