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Tomosynthesis Enhances Identification of Infiltrating Ductal Carcinoma in Women at Increased Risk of Breast Cancer

By MedImaging International staff writers
Posted on 02 May 2013

Three-dimensional (3D) mammography, also known as tomosynthesis, is superior at revealing infiltrating ductal carcinoma than 2D mammography in women at increased risk of breast cancer. As part of a new study, six breast-imaging specialists reviewed both 2D and 3D mammography images of 56 tumors detected in patients at intermediate or high risk of breast cancer.

“We found that 41% (23/56 cancers) were better seen on tomosynthesis and 4% (2/56) were only seen on tomosynthesis,” said Dr. Sarah O'Connell, from South Shore Medical Center (Norwell, MA, USA), and a lead author of the study. Thirty percent of tumors (17/56) were better visualized on 2D mammography but none were seen only on 2D mammography. The remaining were gauged by the breast imaging specialists as being equally visible on both 2D and 3D imaging, she reported. “The majority of cancers seen better or only on tomosynthesis were predominantly infiltrating ductal carcinoma, which typically presents as a mass, focal asymmetry, or architectural distortion,” said Dr. O'Connell.

Most of the tumors better seen or only on 2D mammography were ductal carcinoma in situ (DCIS), which present as calcifications, according to Dr. O'Connell. “This was not surprising because tomosynthesis gives us the ability to scroll through the breast tissue in 1-mm sections, which provides us with more detail, but also may separate a cluster of calcifications, making them more difficult to identify,” said Dr. O'Connell. She noted that work is being done to optimize visualization of calcifications on tomosynthesis.

The advantages of tomosynthesis are predominantly pertinent to women at increased risk of breast cancer who have increased concerns about breast screening and have the potential for biologically aggressive cancers, noted Dr. O'Connell.

The study’s findings were presented in April 16, 2013, at the American Roentgen Ray Society (ARRS) annual meeting in Washington DC (USA).

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68 (51.975250244141): SELECT fid FROM jos_deeppockets WHERE id=294746046 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294746046 AND published='1' LIMIT 1

69 (53.882598876953): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (431.77604675293): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746046 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (396.0132598877): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746046 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 7992.9828643799): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (115.87142944336): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (77.009201049805): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746046 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (41.007995605469): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746046 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (44.822692871094): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (76.055526733398): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (208.13941955566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

105 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

106 (98.943710327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746046 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (715.01731872559): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746046 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 4171.1330413818): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

109 (!!!!! 1254.0817260742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

110 (!!!!! 3726.9592285156): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294746046 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (786.06605529785): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294746046 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1026.1535644531): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (605.10635375977): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (548.8395690918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

115 (109.91096496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

116 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

117 (627.04086303711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

118 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

119 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

120 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

121 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

122 (!!!!! 2153.8734436035): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 71801.900863647): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (776.05247497559): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746046 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746046 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 10627.031326294): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (111.10305786133): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (416.04042053223): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (265.12145996094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (262.97569274902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (72.956085205078): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (280.85708618164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (547.88589477539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (460.86311340332): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (295.16220092773): SELECT name FROM jos_deeppockets WHERE id=211

138 (40.054321289062): SELECT name FROM jos_deeppockets WHERE id=211

139 (634.90867614746): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (740.05126953125): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (118.01719665527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

142 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

143 (!!!!! 11924.982070923): TRUNCATE TABLE jos_trademed_module

144 (152.1110534668): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746046 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746046 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (683.06922912598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

149 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

150 (!!!!! 2036.8099212646): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

152 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

153 (61.988830566406): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746046 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746046 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (50.783157348633): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (48.160552978516): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (53.882598876953): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

158 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746046 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746046 AND published='1' LIMIT 1

159 (154.01840209961): select jos_twitters.link from jos_twitters where cat=10

160 (56.028366088867): select jos_facebook.link from jos_facebook where cat=10

161 (72.956085205078): select jos_google_plus.link from jos_google_plus where cat=10

162 (52.928924560547): select jos_linkedin.link from jos_linkedin where cat=10

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