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Brain Toxicity Map May Help Protect Cognition for Cancer Patients

By MedImaging International staff writers
Posted on 04 Apr 2013

New research is giving radiation oncologists who treat brain tumors a better determination of how to maintain the brain’s functions while still killing cancer.

Ann M. Peiffer, PhD, assistant professor of radiation oncology at Wake Forest Baptist Medical Center (Winston-Salem, NC, USA), and colleagues looked at how radiation treatment to different brain region impacts function to help protect cognition for patients during and after radiation therapy and beyond.

Treating cancerous organs with radiation is devised to give enough of a dose to be toxic to the cancer tumor with minimal impact to the neighboring tissue and circumvent normal tissue death. For treatment of organs such as the lung, liver, or kidney, clinicians know precisely how much radiation to give before organ function is affected.

However, the same is not true for brain tissue, so the researchers worked to develop a “toxicity map” of the brain to preserve function. Dr. Peiffer noted that this is the first attempt to relate treatment dose to brain function, as opposed to brain tissue death. While avoiding healthy tissue death is important, it does not automatically help prevent the cognitive and functional problems associated with cancer treatments. “The issue is the toxicity to the brain and its function, which is cognition or how you think, and these functions are affected at a much lower dose of radiation than what causes tissue death,” Dr. Peiffer said.

The toxicity map was generated by exploiting the data from larger clinical trials held at Wake Forest Baptist. In one of those trials, 57 brain cancer survivors returned six months or more after their radiation treatment to determine whether Donepezil, a drug normally used to improve mental function for those with early Alzheimer’s disease, was effective at improving their cognition. Participants completed cognitive testing upon enrollment, and their scores provided the performance data for the toxicity map. The researchers then went back into the medical records to match participants to their individual radiation dose levels and MRI scans captured before treatment, according to Dr. Peiffer.

“By matching cognitive performance to these measurements, we determined which area of the brain and what dose influenced performance on the cognitive tasks,” Dr. Peiffer said. “This gave us a preliminary look at what areas are important to consider for protecting cognition during our planning for radiation treatment.”

Dr. Peiffer reported that by looking at the irradiation dose received by specific brain regions important to different cognitive functions, tolerance levels related to function could be ascertained. The exposed amount of these vital brain areas were then related to outcomes of specific tests used to assess cognition or the ability of the patients to think and perform tasks, such as remembering a grocery list or what a drawing looked like, she noted. “As technology advances and we are able to spare increasing amounts of normal tissue and important functional structures during treatment, it is important to understand and be able to predict the threshold that we need to maintain to prevent treatment toxicities in function,” Dr. Peiffer said.

New developments in cancer treatment have increased survivorship rates and the length of time individuals are able to live following treatment, according to Dr. Peiffer, and quality of life becomes a very significant matter for these patients. More research, however, is necessary to validate these data, she said.

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63 (452.99530029297): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (!!!!! 3265.8576965332): select jos_twitters.link from jos_twitters where cat=10

65 (125.88500976562): select jos_facebook.link from jos_facebook where cat=10

66 (48.87580871582): select jos_google_plus.link from jos_google_plus where cat=10

67 (34.093856811523): select jos_linkedin.link from jos_linkedin where cat=10

68 (36.954879760742): SELECT fid FROM jos_deeppockets WHERE id=294745511 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294745511 AND published='1' LIMIT 1

69 (35.04753112793): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (485.89706420898): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745511 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (292.06275939941): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745511 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1262.903213501): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (130.89179992676): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (86.069107055664): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745511 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (41.007995605469): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745511 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (44.107437133789): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (78.201293945312): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (40.769577026367): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (126.83868408203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

105 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

106 (102.04315185547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745511 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (731.9450378418): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745511 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 6091.1178588867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

109 (174.99923706055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

110 (64.849853515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294745511 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (615.11993408203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294745511 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1265.0489807129): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (671.1483001709): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (485.18180847168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

115 (!!!!! 3385.066986084): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

116 (!!!!! 1573.0857849121): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

117 (342.84591674805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

118 (115.87142944336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

119 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

120 (!!!!! 1074.0756988525): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

121 (!!!!! 3867.8646087646): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

122 (210.04676818848): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 130002.02178955): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1159.1911315918): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745511 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745511 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 62040.090560913): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 1553.0586242676): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 6923.1986999512): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (149.96528625488): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 10999.917984009): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (!!!!! 2392.053604126): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (!!!!! 6477.1175384521): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (87.02278137207): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (!!!!! 2912.0445251465): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (!!!!! 1206.1595916748): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 1049.9954223633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (562.90626525879): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (333.07075500488): SELECT name FROM jos_deeppockets WHERE id=211

138 (33.855438232422): SELECT name FROM jos_deeppockets WHERE id=211

139 (865.93627929688): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1677.0362854004): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1370.906829834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

142 (232.93495178223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

143 (!!!!! 14650.106430054): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 7574.0814208984): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745511 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 1558.0654144287): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745511 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 2293.8251495361): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (266.07513427734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 3090.1432037354): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

149 (883.10241699219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

150 (!!!!! 9581.0890197754): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (463.00888061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

152 (504.0168762207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

153 (733.85238647461): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745511 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745511 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (616.07360839844): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (341.17698669434): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (434.87548828125): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 3109.9319458008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

158 (370.97930908203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745511 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745511 AND published='1' LIMIT 1

159 (!!!!! 2751.1119842529): select jos_twitters.link from jos_twitters where cat=10

160 (299.93057250977): select jos_facebook.link from jos_facebook where cat=10

161 (47.922134399414): select jos_google_plus.link from jos_google_plus where cat=10

162 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

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