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3D Mammography Combined with 2D Breast Exam Detects More Tumors

By MedImaging International staff writers
Posted on 22 Jan 2013
A Norwegian breast cancer screening trial concluded that the use of three-dimensional (3D) mammography combined with a 2D breast exam identified considerably detected more tumors than a 2D breast exam by itself.

Hologic, Inc. More...
(Bedford, MA, USA), a developer, manufacturer, and supplier of diagnostics, medical imaging systems, and surgical products focused on serving the healthcare needs of women, reported that new study findings revealed that by adding of 3D mammography, also known as breast tomosynthesis, screening modality to a 2D breast screening scan significantly increased cancer detection while reducing the number of false-positives.

The study was led by Per Skaane, MD, PhD, from Oslo University Hospital Ullevaal (Norway). The study was based on 12,631 screening examinations in a large hospital in Norway. The researchers using Hologic’s 3D mammography technology in combination with a 2D mammogram found a significant increase in cancer detection rates, particularly for invasive cancers, and a simultaneous decrease in false-positive rates compared with 2D mammography alone. Significant findings include a 40% increase in the detection of invasive breast cancers; 27% increase in the detection of all cancers (invasive and in situ cancers combined); and, 15% decrease in false-positive rates.

The authors reported that the increase in cancer detection was found across all breast tissue densities, from dense to fatty. At the same time, there was no increase in the identification of ductal carcinoma in situ (DCIS), which is noninvasive and cited by critics of mammography screening as potentially being over-diagnosed.

As a consequence of the large increase in the detection of invasive cancers instead of in situ cancers the authors of the article, wrote, “Perhaps our most important observation is that with the mammography-plus-tomosynthesis arm, the actual benefit, in terms of possibly improving outcome owing to earlier detection, may be larger than merely the difference in the total count or number of detected cancers.”

Rob Cascella, Hologic’s president and chief executive officer, said, “A number of major papers demonstrating the value of 3D mammography have been published in the last few months. The Oslo trial is the first large-scale prospective study to show the additional cancers found with 3D mammography in combination with 2D mammography were invasive cancers—the very type of cancers we want to detect and treat early. 3D mammography is the best breast screening technology to date in that it finds significantly more invasive cancers while also reducing false positives. Most other imaging technologies for screening require users to compromise specificity [recall rate] for sensitivity [cancer detection]. We believe the value of 3D mammography in breast cancer screening is most compelling.”

3D mammography was approved for clinical use for breast cancer screening and diagnosis in the United States in February 2011 and has been available in countries recognizing the CE marking since 2008. Hologic’s 3D mammography technology is in use in 47 states and 30 countries outside the United States. Unlike a screening 2D digital mammogram, which involves a single X-ray image of the breast, 3D mammography captures multiple, low-dose images from multiple angles around the breast. The images are then used to generate a 3D reconstruction of the breast.

Dr. Per Skaane and his research team in Oslo are well known for their research. Their Oslo I and Oslo II trials were significant studies comparing 2D digital mammography to screen-film for the detection of breast cancer.

The study was published online January 2013, in advance of print, in Radiology, the Radiological Society of North America scientific journal website.

Related Links:

Hologic
Oslo University Hospital Ullevaal



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86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
87 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
88 (58.889389038086): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744399 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744399 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
90 (34.093856811523): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
91 (64.13459777832): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (!!!!! 1198.0533599854): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (65.803527832031): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1
105 (99.18212890625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
106 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
107 (152.1110534668): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744399 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (738.14392089844): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744399 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
109 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
110 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
111 (63.896179199219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294744399 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (689.02969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294744399 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
113 (!!!!! 1000.1659393311): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (!!!!! 3524.0650177002): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
115 (211.00044250488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
116 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
117 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
118 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
119 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
120 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
121 (100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
122 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
123 (472.06878662109): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
124 (!!!!! 57909.965515137): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
125 (!!!!! 1093.864440918): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744399 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744399 AND type='deeppockets_item' AND published='1' LIMIT 1
126 (!!!!! 45242.071151733): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (!!!!! 4184.0076446533): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
128 (406.02684020996): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (155.92575073242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
130 (520.94459533691): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
132 (411.9873046875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (216.00723266602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
134 (266.07513427734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (718.11676025391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
136 (600.81481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (453.94897460938): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
138 (77.009201049805): SELECT name FROM jos_deeppockets WHERE id=211
139 (46.014785766602): SELECT name FROM jos_deeppockets WHERE id=211
140 (814.19944763184): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (833.98818969727): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
142 (124.93133544922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
143 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
144 (!!!!! 21149.873733521): TRUNCATE TABLE jos_trademed_module
145 (!!!!! 3006.9351196289): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744399 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (!!!!! 3510.9519958496): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744399 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
147 (849.00856018066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (169.03877258301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
149 (905.03692626953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
150 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
151 (!!!!! 2571.8212127686): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
152 (!!!!! 1213.0737304688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
153 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
154 (91.075897216797): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744399 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744399 AND type='deeppockets_item' AND published='1' LIMIT 1
155 (59.843063354492): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
156 (46.968460083008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
157 (570.05882263184): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
158 (749.82643127441): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
159 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744399 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744399 AND published='1' LIMIT 1
160 (90.837478637695): select jos_twitters.link from jos_twitters where cat=10
161 (251.05476379395): select jos_facebook.link from jos_facebook where cat=10
162 (46.968460083008): select jos_google_plus.link from jos_google_plus where cat=10
163 (41.007995605469): select jos_linkedin.link from jos_linkedin where cat=10