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Fasting Makes Brain Tumors More Susceptible to Radiation Therapy

By MedImaging International staff writers
Posted on 20 Sep 2012

A new study is the first to show that controlled fasting improves the effectiveness of radiation therapy in cancer treatments, increasing life expectancy in mice with aggressive brain tumors.

Earlier research conducted by University of Southern California (USC; Los Angeles, USA) professor of gerontology and biological sciences Dr. More...

Valter Longo, corresponding author on the study and director of the Longevity Institute at the USC Davis School of Gerontology, has shown that short-term fasting protects healthy cells while leaving cancer cells vulnerable to the toxic effects of chemotherapy.

The latest study, which was published September 2012 in the online journal PLoS ONE, is the first to demonstrate that periods of fasting appear to have the same boosting effect on radiation therapy in treating gliomas, the most typically diagnosed brain tumor. Gliomas have a median survival of less than two years.

“With our initial research on chemotherapy, we looked at how to protect patients against toxicity. With this research on radiation, we’re asking, what are the conditions that make cancer most susceptible to treatment? How can we replicate the conditions that are least hospitable to cancer?” Dr. Longo questioned.

Dr. Longo and his coinvestigators, including Dr. Thomas Chen, codirector of the USC Norris neuro-oncology program, examined the combination of fasting with radiation therapy and with the chemotherapy drug Temozolomide, currently the standard treatment for the treatment of brain tumors in adults after an attempt at surgical removal.

The researchers discovered that controlled short-term fasting in mice, no more than 48 hours each cycle, improved the effectiveness of radiation and chemotherapy in treating gliomas. In spite of the extremely aggressive growth of the type of brain tumor studied, more than twice as many mice that fasted and received radiation therapy survived to the end of the trial period than survived with radiation alone or fasting alone.

“The results demonstrate the beneficial role of fasting in gliomas and their treatment with standard chemotherapy and radiotherapy,” the researchers wrote in their article. They noted that the findings indicated the benefits of short-term, controlled fasting for humans receiving treatment for brain tumors.

Dr. Longo cautioned that patients should consult with their oncologist before undertaking any fasting. “You want to balance the risks. You have to do it right. But if the conditions are such that you’ve run out of options, short-term fasting may represent an important possibility for patients.”

USC Norris Cancer Center, Mayo Clinic (Rochester, MN, USA), and Leiden University Hospital (The Netherlands) are all conducting clinical trials on fasting and chemotherapy. A clinical trial on glioma, fasting, and radiotherapy is being considered at USC.

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62 (179.05235290527): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

63 (689.98336791992): SELECT fid FROM jos_deeppockets WHERE id=294742607 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294742607 AND published='1' LIMIT 1

64 (82.015991210938): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

65 (90.122222900391): select jos_twitters.link from jos_twitters where cat=10

66 (60.081481933594): select jos_facebook.link from jos_facebook where cat=10

67 (49.114227294922): select jos_google_plus.link from jos_google_plus where cat=10

68 (46.968460083008): select jos_linkedin.link from jos_linkedin where cat=10

69 (77.962875366211): SELECT fid FROM jos_deeppockets WHERE id=294742607 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294742607 AND published='1' LIMIT 1

70 (63.896179199219): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

71 (365.01884460449): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294742607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (358.10470581055): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294742607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (62.942504882812): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (92.029571533203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (95.844268798828): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294742607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (51.975250244141): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294742607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (52.928924560547): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (117.06352233887): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (!!!!! 3295.1831817627): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (112.05673217773): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

106 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

107 (102.99682617188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294742607 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (94.175338745117): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294742607 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

110 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

111 (114.91775512695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294742607 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (516.89147949219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294742607 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (!!!!! 1685.8577728271): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 4099.8458862305): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

116 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

117 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

118 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

119 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

120 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

121 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

122 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

123 (313.99726867676): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 46344.041824341): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (!!!!! 5047.082901001): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294742607 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294742607 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 17818.927764893): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 5878.9253234863): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (68.902969360352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (61.988830566406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (401.97372436523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (!!!!! 2991.9147491455): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (422.95455932617): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (46.014785766602): SELECT name FROM jos_deeppockets WHERE id=211

139 (30.994415283203): SELECT name FROM jos_deeppockets WHERE id=211

140 (721.93145751953): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (618.93463134766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

143 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

144 (!!!!! 13508.796691895): TRUNCATE TABLE jos_trademed_module

145 (83.208084106445): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294742607 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294742607 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (!!!!! 1127.9582977295): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

150 (!!!!! 3702.8789520264): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

151 (!!!!! 1230.9551239014): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

153 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

154 (34.809112548828): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294742607 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294742607 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

157 (31.948089599609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

159 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742607 AND published='1' LIMIT 1

160 (35.04753112793): select jos_twitters.link from jos_twitters where cat=10

161 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

162 (28.848648071289): select jos_google_plus.link from jos_google_plus where cat=10

163 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

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