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Interventional Radiology Treatments Designed for Disc Disease, Weight Loss

By MedImaging International staff writers
Posted on 11 Apr 2012

A minimally invasive radiotherapy is under development to target hunger, another utilizes X-ray visible embolic beads to block arteries to the stomach and suppress hunger, and a third treatment investigates the use of stem cells to repair vertebral disc degeneration.

Preliminary findings from all these studies were reported at the Society of Interventional Radiology’s (SIR) 37th annual scientific meeting held on March 24-29, 2012 in San Francisco, CA, USA. The rate of morbid obesity in the United States is also rising rapidly. Two new studies that explored the use of established interventional radiology treatments in new ways may have the potential to help individuals with morbid obesity.

“Currently, there are three clinically viable surgical alternatives for obesity: gastric bypass surgery, gastric pacing, and endoscopic gastric banding. These procedures have varying success rates; they are invasive, require extensive gastric/bowel reconstruction or external devices and can have significant surgical complications,” explained Charles Y. Kim, MD, assistant professor of radiology at Duke University Medical Center (Durham, NC, USA), and lead investigator on one of the studies.

“Our promising results led us to believe that a minimally invasive interventional radiology treatment--called bariatric arterial embolization--would allow for precise targeting of a specific portion of a person’s stomach in order to decrease production of ghrelin, a hormone that causes hunger. This treatment could one day be the answer for those who have not been successful with weight loss through diet and exercise,” stated Dr. Kim.

“Interventional radiologists have safely and effectively used embolization in many other disease states for decades,” stated Dr. Kim. “For this study, we selectively blocked and decreased the blood flow to a very specific part of the stomach using specialized radiologic equipment, which led to significantly decreased levels of ghrelin in the animals that we treated. We found that when ghrelin levels decrease, appetite and hunger also decrease, causing weight loss in the treated animals relative to nontreated animals,” Dr. Kim continued. “Bariatric arterial embolization may have a future use in treating obesity in humans by significantly suppressing appetite to achieve weight loss,” he said.

The researchers will continue studies aimed at the reduction and elimination of complications, such as stomach ulcers, and expressed confidence that bariatric arterial embolization is very close to moving toward the clinical trial phase in the United States.

A second study tested a new type of X-ray-visible embolic bead in bariatric arterial embolization. “Until now, clinically available embolic beads have not been visible on X-ray during or after delivery. We developed a new embolic bead that can be seen directly by X-ray imaging and have tested them in the new bariatric embolization treatment for obesity,” explained Clifford R. Weiss, MD, assistant professor of radiology at Johns Hopkins University School of Medicine (Baltimore, MD, USA). “The current system requires that the beads be mixed with X-ray-visible contrast agents before delivery. Although this mixture is visible during infusion, the contrast immediately washes away, and the location of the beads can no longer be ‘tracked,’” Dr. Weiss said. “By making the beads X-ray visible and using them in tandem with C-arm cone-beam CT--a new way of X-ray imaging that creates 3D pictures--these beads can be tracked both during and after delivery. This allows for more precise assessment of ‘on-target’ embolization. Due to the fact that these beads are visible and can be tracked over time, we should be able to assess their long-term presence. If needed, the patient can then be retreated. With the current clinically available beads, it is not possible to determine whether they are intact and functional over time. We recommend further studies to prove the beads’ safety over time and ensure they do not have any unintended effects on the target organs or on the individuals being treated. We believe there are myriad possible applications for these beads, such as treating cancer of the liver or noncancerous uterine masses,” stated Dr. Weiss.

In a third study, researchers showed in animals that stem cells can be injected using only a needle, under X-ray guidance, into degenerated, painful intervertebral discs and initiate their repair. “Even though 80% of people will have painful degenerated discs by age 65 and degenerated intervertebral discs are a significant contributor to low back pain, effective therapies are lacking. The current treatment is surgical removal of these damaged discs, and this often requires more than one surgical procedure. Interventional radiologists acted on a need for a minimally invasive treatment that could mean faster recovery and less need for repeat surgeries in individuals suffering from debilitating disc disease,” explained J. David Prologo, MD, an interventional radiologist at University Hospitals Case Medical Center (Cleveland, OH, USA).

“Stem cell therapies are increasingly showing great promise for disc regeneration and biological repair and may represent a promising alternative to destroying the disc, replacement, or immobilization,” noted Dr. Prologo. “All adults have stem cells that can be isolated from their bone marrow, and we observed that repair could be achieved by injecting a person's own stem cells into the bad discs,” said Dr. Prologo. “After attaching an imaging agent to the injected cells, we were able to prove accurate delivery and containment of those cells at the desired site of action. And, we are now performing the first in human trials of this technique,” he added.

“The use of interventional radiology for the delivery of regenerative therapies, such as stem cells, can lead to other minimally invasive procedures associated with potential symptom relief and decreased cost and complications associated with open surgery,” Dr. Prologo stated. “This research may serve as a precedent for a wide variety of stem cell applications in humans through interventional radiology.”

Related Links:
Society of Interventional Radiology
Duke University Medical Center
Johns Hopkins University School of Medicine

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56 (856.16111755371): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294740154 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 3071.0697174072): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

58 (!!!!! 1119.85206604): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

59 (!!!!! 9703.1593322754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

60 (765.08522033691): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

61 (!!!!! 6516.9334411621): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 2221.1074829102): SELECT fid FROM jos_deeppockets WHERE id=294740154 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294740154 AND published='1' LIMIT 1

63 (!!!!! 1162.052154541): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (!!!!! 4102.9453277588): select jos_twitters.link from jos_twitters where cat=10

65 (65.088272094727): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 3600.8358001709): select jos_google_plus.link from jos_google_plus where cat=10

67 (75.101852416992): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 1842.0219421387): SELECT fid FROM jos_deeppockets WHERE id=294740154 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294740154 AND published='1' LIMIT 1

69 (303.03001403809): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (!!!!! 1312.0174407959): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294740154 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 9479.9995422363): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294740154 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (339.98489379883): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (128.98445129395): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (74.863433837891): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (97.990036010742): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 1353.9791107178): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294740154 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (92.983245849609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294740154 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 3874.0634918213): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (153.0647277832): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (120.16296386719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

105 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

106 (92.029571533203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294740154 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (708.10317993164): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294740154 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (219.10667419434): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

109 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

110 (110.14938354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294740154 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 2822.1607208252): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294740154 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (798.94065856934): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 1271.0094451904): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

115 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

116 (535.01129150391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

117 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

118 (375.98609924316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

119 (!!!!! 1493.9308166504): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

120 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

121 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

122 (527.85873413086): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 59473.991394043): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (848.05488586426): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294740154 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294740154 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 22277.83203125): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (77.962875366211): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (74.863433837891): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (258.9225769043): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (175.95291137695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (519.0372467041): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (280.85708618164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (679.01611328125): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (64.849853515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (613.92784118652): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (443.93539428711): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (340.93856811523): SELECT name FROM jos_deeppockets WHERE id=211

138 (57.93571472168): SELECT name FROM jos_deeppockets WHERE id=211

139 (668.04885864258): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (662.08839416504): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (94.175338745117): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

142 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

143 (!!!!! 30508.041381836): TRUNCATE TABLE jos_trademed_module

144 (217.91458129883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294740154 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (131.84547424316): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294740154 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1216.8884277344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (130.17654418945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (145.19691467285): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

149 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

150 (!!!!! 4137.9928588867): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 3592.9679870605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

152 (179.05235290527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

153 (85.115432739258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294740154 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294740154 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (38.14697265625): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (77.962875366211): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (202.89421081543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

158 (121.11663818359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740154 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740154 AND published='1' LIMIT 1

159 (78.916549682617): select jos_twitters.link from jos_twitters where cat=10

160 (!!!!! 5497.932434082): select jos_facebook.link from jos_facebook where cat=10

161 (123.02398681641): select jos_google_plus.link from jos_google_plus where cat=10

162 (53.882598876953): select jos_linkedin.link from jos_linkedin where cat=10

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