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Combo Tumor Treatment Elicits Sarcoma Tumor Immune Response

By MedImaging International staff writers
Posted on 22 Mar 2012

A team of 18 researchers has found that treating high risk, soft tissue sarcoma patients with a combination of implanted dendritic cells and fractionated external beam radiation (EBRT) provided more than 50% of their trial patients with tumor-specific immune responses lasting from 11 to 42 weeks.

The study, conducted by investigators from Moffitt Cancer Center (Tampa, FL, USA), was published in the February 1, 2012, issue of the International Journal of Radiation Oncology • Biology • Physics, the journal of the American Society for Radiation Oncology (ASTRO). “Sarcomas are relatively rare forms of cancer with about 10,000 new cases in the US annually,” said study coauthor Dmitry Gabrilovich, MD, PhD, senior member of the Moffitt department of immunology.

The researchers noted that because 50% of patients with large, high-grade soft tissue sarcomas develop distant metastasis, new, effective treatments are warranted. “Unfortunately, conventional therapy for large, high-grade tumors is frequently systematically ineffective, making this a very deadly problem,” Dr. Gabrilovich said.

According to the scientists, administration of dendritic cells has been found to be a potential technique for generating an immune response because dendritic cells process antigen material and present it to other immune cells. Dendritic cells act as immune system messengers.

“Many studies have shown that preoperative radiotherapy and surgery is effective in treating many soft tissue sarcomas with high-risk features,” said Dr. Gabrilovich. “We designed our study to investigate the effect of combining the administration of dendritic cells and EBRT for patients with soft tissue, high-risk sarcomas.”

The researchers hypothesized that if dendritic cell implants were combined with EBRT (the most common kind of radiotherapy treatment that not only can kill tumor cells but release tumor antigens) the combination therapy might be complimentary when the dendritic cells helped process tumor antigens released by the EBRT treatment. “The combination treatment resulted in dramatic increases in immune T cells in the tumors,” explained Dr. Gabrilovich. "The presence of T cells in the tumors positively correlated with the development of tumor-specific immune responses.”

A finding in this study was that no patient had significant tumor specific immune responses before the combined therapy. After the combination treatment, tumor-specific responses were observed in 52.9% of trial patients. The researchers reported that the combination treatment was “well tolerated” and that 12 of the 17 patients in the clinical trial were “progression-free” after one year.

The authors concluded that given that the combination therapy proved effective in creating a potent antitumor response and was safe, producing no adverse side effects, larger trials with greater numbers of patients were necessary.

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66 (46.968460083008): select jos_google_plus.link from jos_google_plus where cat=10

67 (34.809112548828): select jos_linkedin.link from jos_linkedin where cat=10

68 (38.14697265625): SELECT fid FROM jos_deeppockets WHERE id=294739911 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294739911 AND published='1' LIMIT 1

69 (46.014785766602): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (426.05400085449): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739911 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (324.01084899902): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739911 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1710.8917236328): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (97.036361694336): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (51.975250244141): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739911 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (35.04753112793): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739911 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (39.100646972656): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (64.849853515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (112.05673217773): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

105 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

106 (73.909759521484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739911 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (68.187713623047): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739911 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (95.844268798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

109 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

110 (70.095062255859): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294739911 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (679.01611328125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294739911 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (728.84559631348): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (540.01808166504): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (164.98565673828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

115 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

116 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

117 (55.789947509766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

118 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

119 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

120 (125.16975402832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

121 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

122 (523.09036254883): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 30219.078063965): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (622.98774719238): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739911 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739911 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 10500.192642212): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (92.029571533203): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (377.89344787598): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (119.92454528809): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (260.82992553711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (94.175338745117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (237.94174194336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (84.877014160156): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (267.98248291016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (632.04765319824): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (409.12628173828): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (298.02322387695): SELECT name FROM jos_deeppockets WHERE id=211

138 (44.822692871094): SELECT name FROM jos_deeppockets WHERE id=211

139 (707.86476135254): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (600.81481933594): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

142 (110.14938354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

143 (!!!!! 10488.033294678): TRUNCATE TABLE jos_trademed_module

144 (149.01161193848): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739911 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (74.148178100586): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739911 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (754.83322143555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

149 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

150 (!!!!! 1716.8521881104): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

152 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

153 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739911 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739911 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (43.153762817383): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (41.007995605469): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (43.153762817383): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

158 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739911 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739911 AND published='1' LIMIT 1

159 (282.04917907715): select jos_twitters.link from jos_twitters where cat=10

160 (45.061111450195): select jos_facebook.link from jos_facebook where cat=10

161 (44.107437133789): select jos_google_plus.link from jos_google_plus where cat=10

162 (39.100646972656): select jos_linkedin.link from jos_linkedin where cat=10

163 (319.00405883789): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1183.032989502): insert into jos_banners_delta values (14615,'2025-08-19 21:06:11','216.73.216.0','view'),(14202,'2025-08-19 21:06:11','216.73.216.0','view'),(14203,'2025-08-19 21:06:11','216.73.216.0','view')

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