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Fetus Exposed to Radiation Has Increased Risk of Testicular Cancer

By MedImaging International staff writers
Posted on 08 Mar 2012
Male fetuses of mothers that are exposed to radiation during early pregnancy may have an increased chance of developing testicular cancer, according to recent study in lab mice.

The article was published February 15, 2012, in the journal PLoS ONE. The study is the first to find an environmental cause for testicular germ cell tumors, the most common cancer in young Caucasian men. “This discovery launches a major shift in the current research model, placing DNA-damaging agents in the forefront as likely mediators of testicular cancer induction,” said corresponding author Gunapala Shetty, PhD, assistant professor in the University of Texas MD Anderson Cancer Center’s (Houston, USA) department of experimental radiation oncology.

According to the American Cancer Society (Houston, TX, USA), more than 8,500 new instances of testicular cancer are diagnosed each year in the United States. During the past 50 years, the incidence has tripled in young Caucasian men worldwide. “This increase and the characteristics of germ cell tumors strongly suggest that fetal exposure to an environmental agent is responsible,” Dr. Shetty said. “However, the identification of any agent producing increases in testicular cancer has eluded scientists.”

Endocrine disruptors, compounds that alter the endocrine--or hormonal--system, have been widely believed to be the cause of testicular cancer, but there has been no evidence. Fetuses are particularly susceptible to even small amounts of the substances, which are known to cause developmental and cognitive issues.

This study started as an examination of endocrine disruptors as a possible cause of testicular cancer. Researchers separately tested two such compounds, the estrogen diethylstilbestrol (DES) and the anti-androgen flutamide. The endocrine disruptors were introduced into a mouse strain with a high spontaneous incidence of testicular cancer, which should make them more sensitive to cancer caused by environmental agents. However, the study’s findings revealed no increase in testicular cancer. However, when researchers gave small doses of radiation, which is a DNA-damaging agent, to female mice in the middle of their pregnancies, all the male offspring developed testicular cancer, compared to 45% of mice not exposed to radiation. Moreover, the tumors were more aggressive and had more sites of origin.

This study suggests that DNA-damaging agents, instead of endocrine disruptors, should be assessed as a factor in the increased prevalence of testicular cancer. “Although radiation exposure of pregnant females has been declining and is unlikely to be responsible for this increase, we intend to follow this up with studies of DNA-damaging chemicals found in cigarette smoke and air pollution, to which exposures of pregnant women have been increasing,” said study senior author Marvin Meistrich, PhD, professor in MD Anderson’s department of experimental radiation oncology.

This study opens the way for wide-ranging study, and researchers agree much work remains to be done. “A second class of DNA-damaging agents that we intend to study is chemotherapy drugs like cyclophosphamide, which are used to treat pregnant women with breast cancer,” Dr. Shetty said. “Studies at MD Anderson of the children of these women did not show increases in birth or developmental defects. However, we need to test these agents in our animal model since testicular cancer usually does not appear until early adulthood.”

Related Links:
University of Texas MD Anderson Cancer Center


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87 (!!!!! 2438.0683898926): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739683 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
88 (92.983245849609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739683 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (56.982040405273): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (746.9654083252): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (306.84471130371): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (440.12069702148): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (54.836273193359): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (!!!!! 1341.1045074463): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (187.87384033203): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (!!!!! 1403.0933380127): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (401.97372436523): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (118.01719665527): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (!!!!! 2876.9969940186): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
105 (563.8599395752): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
106 (!!!!! 7812.9768371582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739683 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (807.04689025879): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739683 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (!!!!! 8293.8671112061): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
109 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
110 (69.856643676758): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294739683 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (998.97384643555): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294739683 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (!!!!! 7581.9492340088): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (!!!!! 1562.8337860107): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
115 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
116 (165.93933105469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
117 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
118 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
119 (60.796737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
120 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
121 (!!!!! 1384.973526001): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
122 (746.01173400879): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 82676.17225647): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (!!!!! 3367.9008483887): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739683 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739683 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 20438.90953064): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (164.03198242188): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (!!!!! 1440.0482177734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (139.95170593262): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (!!!!! 6259.9182128906): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (!!!!! 5033.016204834): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (!!!!! 6939.8880004883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (!!!!! 2878.1890869141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (162.12463378906): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (97.990036010742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (828.98139953613): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (571.96617126465): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (527.14347839355): SELECT name FROM jos_deeppockets WHERE id=211
138 (61.03515625): SELECT name FROM jos_deeppockets WHERE id=211
139 (900.9838104248): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (!!!!! 1003.0269622803): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (!!!!! 2288.1031036377): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
142 (124.93133544922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
143 (!!!!! 22593.975067139): TRUNCATE TABLE jos_trademed_module
144 (!!!!! 13637.065887451): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739683 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (!!!!! 4497.0512390137): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739683 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (!!!!! 2324.104309082): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (281.81076049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (!!!!! 2079.0100097656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
149 (547.17063903809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
150 (!!!!! 3933.1912994385): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (!!!!! 1673.9368438721): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
152 (!!!!! 2057.0755004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
153 (!!!!! 1836.0614776611): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739683 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739683 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (158.07151794434): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
155 (198.1258392334): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
156 (!!!!! 1427.8888702393): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (934.83924865723): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
158 (!!!!! 1224.9946594238): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739683 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739683 AND published='1' LIMIT 1
159 (!!!!! 1856.0886383057): select jos_twitters.link from jos_twitters where cat=10
160 (290.1554107666): select jos_facebook.link from jos_facebook where cat=10
161 (61.988830566406): select jos_google_plus.link from jos_google_plus where cat=10
162 (185.01281738281): select jos_linkedin.link from jos_linkedin where cat=10