Download Mobile App

Video Library

Featured Links

Medical Imaging Equipment
Trademed.com is our new marketplace where you can buy and sell Imaging equipment.

X-Ray Protein Probe May Lead to Potential Anticancer Treatment

By MedImaging International staff writers
Posted on 28 Sep 2011

Researchers have identified a new type of potential anticancer drug, named FOBISIN, which has been shown to target 14-3-3 proteins, important for the uncontrolled growth of cancer cells.

The researchers, from Emory University School of Medicine (Atlanta, GA, USA), were using X-rays to see how FOBISIN fits into the clamp-shaped 14-3-3 protein structure. Unexpectedly, the X-rays induced the compound to be permanently bonded to the protein. The finding suggests that compounds like FOBISIN can be used in combination with radiation to trigger potent anticancer activity. The study’s findings were published online September 2011 in the journal Proceedings of the [US] National Academy of Sciences early edition.

Senior author Haian Fu, PhD, has been studying 14-3-3 proteins for two decades. He is professor of pharmacology and of hematology and oncology at Emory University School of Medicine, and the director of the Emory Chemical Biology Discovery Center. “Targeting 14-3-3 proteins could be especially valuable because they can impact multiple pathways critical for cancer cell growth,” he stated. “14-3-3 proteins have been shown to be dysregulated in a number of cancer types, including lung cancer and breast cancer.”

14-3-3 proteins act as adaptors that fasten onto other proteins. Dr. Fu and coworkers Jing Zhao, postdoctoral fellow, and Yuhong Du, assistant professor and associate director of the Discovery Center, sorted through thousands of chemicals to find one (FOBISIN: Fourteen-three-three binding small molecule inhibitor) that prevents 14-3-3 from interacting with its partners. 14-3-3 proteins are found in mammals, plants, and fungi. In humans, they come in seven varieties, and FOBISIN appears to inhibit interactions by all seven.

A 14-3-3 proteins’ ability to clamp depends on whether the target protein is phosphorylated, a chemical modification that regulates protein function. FOBISIN’s inhibitory power also requires the presence of phosphorylation in the molecule.

Dr. Fu’s group teamed up with the laboratory of Xiaodong Cheng, PhD, cosenior author, professor of biochemistry and a Georgia Research Alliance Eminent Scholar, to examine how FOBISIN fits into its targets.

Scientists use X-rays as a tool to probe protein structure. If a protein and a drug that targets it can be crystallized together, the X-ray diffraction pattern from the crystals reveals the three-dimensional (3D) configuration of the atoms, and how the drug interacts with the protein. Research assistant professor John Horton, PhD, and research associate Anup Upadhyay, PhD, in the Cheng laboratory used synchrotron X-ray radiation from the Advanced Photon Source at Argonne National Laboratory (Argonne, IL, USA) for this purpose. “In this case, the X-rays had an unexpected effect: they caused FOBISIN to become covalently attached to the 14-3-3 protein,” Dr. Cheng commented.

The finding suggests that compounds like FOBISIN could be developed as “pro-drugs” that upon exposure to radiation, permanently adhere to and suppress their targets. A typical strategy in fighting cancer is to combine drugs and radiation so that the drugs increase cells’ sensitivity to radiation. Here, the radiation would activate the drug. “These compounds could be used in combination with other strategies to enhance the tumor selectivity of the treatment,” Dr. Fu said.

Related Links:
Emory University School of Medicine

Visit expo >

Gold Member

Ultrasound System

FUTUS LE

Gold Member

Electrode Solution and Skin Prep

Signaspray

Web-Based DICOM Viewer

iQ-4VIEW

Wireless Flat Panel Detector

ExamVue 10" x 12" Glassless Substrate Wireless

Latest Radiography News

Channels

Radiography

view channel

Image: A 4mm square diamond radiation detector (Photo courtesy of Orbray)

World's Largest Class Single Crystal Diamond Radiation Detector Opens New Possibilities for Diagnostic Imaging

Diamonds possess ideal physical properties for radiation detection, such as exceptional thermal and chemical stability along with a quick response time. Made of carbon with an atomic number of six, diamonds... Read more

Image: The AI-powered FFR assessment is comparable to conventional assessment (Photo courtesy of 123RF)

MRI

view channel

Image: An AI tool has shown tremendous promise for predicting relapse of pediatric brain cancer (Photo courtesy of 123RF)

AI Tool Predicts Relapse of Pediatric Brain Cancer from Brain MRI Scans

Many pediatric gliomas are treatable with surgery alone, but relapses can be catastrophic. Predicting which patients are at risk for recurrence remains challenging, leading to frequent follow-ups with... Read more

AI Tool Tracks Effectiveness of Multiple Sclerosis Treatments Using Brain MRI Scans

Multiple sclerosis (MS) is a condition in which the immune system attacks the brain and spinal cord, leading to impairments in movement, sensation, and cognition. Magnetic Resonance Imaging (MRI) markers... Read more

Ultra-Powerful MRI Scans Enable Life-Changing Surgery in Treatment-Resistant Epileptic Patients

Approximately 360,000 individuals in the UK suffer from focal epilepsy, a condition in which seizures spread from one part of the brain. Around a third of these patients experience persistent seizures... Read more

Image: The automated MRI processing and machine learning software features a noninvasive biomarker technique (Photo courtesy of University of Florida)

AI-Powered MRI Technology Improves Parkinson’s Diagnoses

Current research shows that the accuracy of diagnosing Parkinson’s disease typically ranges from 55% to 78% within the first five years of assessment. This is partly due to the similarities shared by Parkinson’s... Read more

Ultrasound

view channel

AI-Powered Lung Ultrasound Outperforms Human Experts in Tuberculosis Diagnosis

Despite global declines in tuberculosis (TB) rates in previous years, the incidence of TB rose by 4.6% from 2020 to 2023. Early screening and rapid diagnosis are essential elements of the World Health... Read more

Image: Researchers are using AI to analyze images from a common heart test to identify signs of valve disease (Photo courtesy of 123RF)

AI Identifies Heart Valve Disease from Common Imaging Test

Tricuspid regurgitation is a condition where the heart's tricuspid valve does not close completely during contraction, leading to backward blood flow, which can result in heart failure. A new artificial... Read more

Image: Diagram of ULM processing (Photo courtesy of Cyborg and Bionic Systems)

Novel Imaging Method Enables Early Diagnosis and Treatment Monitoring of Type 2 Diabetes

Type 2 diabetes is recognized as an autoimmune inflammatory disease, where chronic inflammation leads to alterations in pancreatic islet microvasculature, a key factor in β-cell dysfunction.... Read more

Image: Artist’s impression of the new ultrasound technique, called nonlinear sound sheet microscopy (Photo courtesy of Maayan Harel/Maresca Lab)

Ultrasound-Based Microscopy Technique to Help Diagnose Small Vessel Diseases

Clinical ultrasound, commonly used in pregnancy scans, provides real-time images of body structures. It is one of the most widely used imaging techniques in medicine, but until recently, it had little... Read more

Nuclear Medicine

view channel

Image: In vivo imaging of U-87 MG xenograft model with varying mass doses of 89Zr-labeled KLG-3 or isotype control (Photo courtesy of L Gajecki et al.; doi.org/10.2967/jnumed.124.268762)

Novel Radiolabeled Antibody Improves Diagnosis and Treatment of Solid Tumors

Interleukin-13 receptor α-2 (IL13Rα2) is a cell surface receptor commonly found in solid tumors such as glioblastoma, melanoma, and breast cancer. It is minimally expressed in normal tissues, making it... Read more

Novel PET Imaging Approach Offers Never-Before-Seen View of Neuroinflammation

COX-2, an enzyme that plays a key role in brain inflammation, can be significantly upregulated by inflammatory stimuli and neuroexcitation. Researchers suggest that COX-2 density in the brain could serve... Read more

Novel Radiotracer Identifies Biomarker for Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC), which represents 15-20% of all breast cancer cases, is one of the most aggressive subtypes, with a five-year survival rate of about 40%. Due to its significant heterogeneity... Read more

Image: A repurposed ALS drug has become an imaging probe to help diagnose neurodegeneration (Photo courtesy of St. Jude Children’s Research Hospital)

Innovative PET Imaging Technique to Help Diagnose Neurodegeneration

Neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease, are often diagnosed only after physical symptoms appear, by which time treatment may no longer be effective.... Read more

General/Advanced Imaging

view channel

Image: The LungVision system has received regulatory approval from the TGA in Australia (Photo courtesy of Body Vision Medical)

AI-Powered Imaging System Improves Lung Cancer Diagnosis

Given the need to detect lung cancer at earlier stages, there is an increasing need for a definitive diagnostic pathway for patients with suspicious pulmonary nodules. However, obtaining tissue samples... Read more

Image: The multimodal multitask foundation model enhances lung cancer screening (Photo courtesy of 123RF)

AI Model Significantly Enhances Low-Dose CT Capabilities

Lung cancer remains one of the most challenging diseases, making early diagnosis vital for effective treatment. Fortunately, advancements in artificial intelligence (AI) are revolutionizing lung cancer... Read more

Image: Axial noncontrast chest CT lung window images of three different sample patches shown in each row (Photo courtesy of Radiology: Cardiothoracic Imaging)

Ultra-Low Dose CT Aids Pneumonia Diagnosis in Immunocompromised Patients

Lung infections can be life-threatening for patients with weakened immune systems, making timely diagnosis crucial. While CT scans are considered the gold standard for detecting pneumonia, repeated scans... Read more

Image: Histologically confirmed lung cancer cases detected at immediate referral after baseline scan or 3-month short-term follow-up (Photo courtesy of DOI:10.1016/j.ejca.2025.115324)

AI Reduces CT Lung Cancer Screening Workload by Almost 80%

Lung cancer impacts over 48,000 individuals in the UK annually, and early detection is key to improving survival rates. The UK Lung Cancer Screening (UKLS) trial has already shown that low-dose CT (LDCT)... Read more

Imaging IT

view channel

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology

The global artificial intelligence (AI) in medical diagnostics market is expanding with early disease detection being one of its key applications and image recognition becoming a compelling consumer proposition... Read more

AI-Based Mammography Triage Software Helps Dramatically Improve Interpretation Process

An artificial intelligence (AI)-based mammography triage software is helping dramatically improve the interpretation process for healthcare providers. In a new study, researchers at the Scripps Green... Read more

Artificial Intelligence (AI) Program Accurately Predicts Lung Cancer Risk from CT Images

An artificial intelligence (AI) program accurately predicts the risk that lung nodules detected on screening CT will become cancerous, according to a study published in the journal Radiology.... Read more

Industry News

view channel

GE HealthCare and NVIDIA Collaboration to Reimagine Diagnostic Imaging

GE HealthCare (Chicago, IL, USA) has entered into a collaboration with NVIDIA (Santa Clara, CA, USA), expanding the existing relationship between the two companies to focus on pioneering innovation in... Read more

Image: The patient-specific 3D-printed phantoms usher in a new era for medical imaging research (Photo courtesy of Siemens Healthineers)

Patient-Specific 3D-Printed Phantoms Transform CT Imaging

New research has highlighted how anatomically precise, patient-specific 3D-printed phantoms are proving to be scalable, cost-effective, and efficient tools in the development of new CT scan algorithms... Read more

Siemens and Sectra Collaborate on Enhancing Radiology Workflows

Siemens Healthineers (Forchheim, Germany) and Sectra (Linköping, Sweden) have entered into a collaboration aimed at enhancing radiologists' diagnostic capabilities and, in turn, improving patient care... Read more

Image: Virtual colonoscopy (CT colonography) is an approved option for screening for colorectal cancer in the US (Photo courtesy of Shtutterstock)

Bracco Diagnostics and ColoWatch Partner to Expand Availability CRC Screening Tests Using Virtual Colonoscopy

Over the last 25 years, virtual colonoscopy has been proven to be a highly accurate, safe, convenient, and cost-effective method of colorectal cancer (CRC) prevention and screening. It can reliably find... Read more

1 (145.91217041016): SET sql_mode = 'MYSQL40'

2 (113.01040649414): SELECT folder, element, published, params FROM jos_mambots WHERE published >= 1 AND access <= 0 AND folder = 'system' ORDER BY ordering

3 (417.94776916504): SELECT template FROM jos_templates_menu WHERE client_id = 0 AND ( menuid = 0 OR menuid = 294737314 ) ORDER BY menuid DESC LIMIT 1

4 (304.9373626709): DELETE FROM jos_session WHERE time < 1755648204 AND guest = 1 AND userid = 0

5 (71.048736572266): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

6 (64.13459777832): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

7 (61.03515625): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

8 (355.00526428223): SELECT * FROM jos_menu WHERE id = 294737314

9 (734.09080505371): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

10 (763.89312744141): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

11 (123.02398681641): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

12 (!!!!! 1281.0230255127): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294737314) AND (fid=211) ORDER BY id DESC, `created` DESC LIMIT 0,16

13 (190.97328186035): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294737314) AND (fid=211) ORDER BY id DESC, `created` DESC LIMIT 0,16

14 (!!!!! 4234.0755462646): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=211 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294737314 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

15 (!!!!! 4059.0763092041): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=211 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294737314 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

16 (!!!!! 2134.0847015381): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294737314 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

17 (!!!!! 1765.9664154053): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294737314 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

18 (104.90417480469): SELECT name,id,title FROM jos_deeppockets WHERE id=211 LIMIT 1

19 (48.87580871582): SELECT name,id,title FROM jos_deeppockets WHERE id=211 LIMIT 1

20 (576.97296142578): SELECT dp.*, ch.title as channel, ch.name as channel_name FROM jos_deeppockets as dp LEFT JOIN jos_deeppockets as ch ON ch.id = dp.fid WHERE 1=1 AND dp.id=294737313 AND dp.type='deeppockets_item' AND dp.published='1' LIMIT 1

21 (574.11193847656): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737313 AND type='deeppockets_item' AND published='1' LIMIT 1

22 (563.14468383789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737313 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

23 (604.86793518066): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737313 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

24 (138.99803161621): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737313 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

25 (58.889389038086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737313 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

26 (600.09956359863): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

27 (589.13230895996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

28 (97.990036010742): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737313 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

29 (83.208084106445): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737313 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

30 (660.18104553223): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737313 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

31 (591.99333190918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737313 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

32 (256.06155395508): SELECT conference_items.channel_id, conference_items.tracking_code FROM conference_items LEFT JOIN conference_groups ON conference_groups.id = conference_items.group_id LEFT JOIN jos_deeppockets ON jos_deeppockets.id = conference_items.channel_id LEFT JOIN jos_journal ON jos_journal.cat = jos_deeppockets.cat AND jos_journal.real = 1 AND jos_journal.directory IS NOT NULL WHERE 1 = 1 ORDER BY conference_items.id

33 (428.91502380371): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294737313 LIMIT 1

34 (80.108642578125): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294737313 LIMIT 1

35 (303.98368835449): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294737313 LIMIT 1

36 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294737313 LIMIT 1

37 (61.988830566406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294737313 LIMIT 1

38 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294737313 LIMIT 1

39 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294737313 LIMIT 1

40 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294737313 LIMIT 1

41 (957.96585083008): SELECT id, title, module, position, content, showtitle, params FROM jos_modules AS m INNER JOIN jos_modules_menu AS mm ON mm.moduleid = m.id WHERE m.published = 1 AND m.access <= 0 AND m.client_id != 1 AND ( mm.menuid = 0 OR mm.menuid = 294737314 ) ORDER BY ordering

42 (!!!!! 1470.8042144775): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

43 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

44 (!!!!! 4094.8390960693): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 98 AND `site_id` = 10 AND `published` = 1

45 (!!!!! 4128.9329528809): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 99 AND `site_id` = 10 AND `published` = 1

46 (169.99244689941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

47 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

48 (212.9077911377): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

49 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

50 (57.220458984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

51 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

52 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

53 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

54 (403.88107299805): SELECT name FROM jos_deeppockets WHERE id=294737314 LIMIT 1

55 (241.99485778809): SELECT name FROM jos_deeppockets_archive WHERE id=294737314 LIMIT 1

56 (47.922134399414): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

57 (74.148178100586): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (603.91426086426): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1217.1268463135): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

60 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

61 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

62 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

63 (103.95050048828): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (568.15147399902): SELECT fid FROM jos_deeppockets WHERE id=294737314 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294737314 AND published='1' LIMIT 1

65 (51.021575927734): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

66 (46.968460083008): select jos_twitters.link from jos_twitters where cat=10

67 (39.815902709961): select jos_facebook.link from jos_facebook where cat=10

68 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

69 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

70 (46.968460083008): SELECT fid FROM jos_deeppockets WHERE id=294737314 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294737314 AND published='1' LIMIT 1

71 (34.093856811523): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

72 (335.9317779541): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737314 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (241.99485778809): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737314 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (39.815902709961): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (65.088272094727): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737314 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (30.994415283203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737314 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (37.908554077148): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (78.916549682617): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (75.101852416992): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (40.769577026367): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

107 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

108 (91.075897216797): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (103.95050048828): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

111 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

112 (520.22933959961): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (519.99092102051): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737313 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (516.89147949219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737313 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (616.07360839844): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (347.85270690918): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

119 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

120 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

121 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

122 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

123 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

124 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

125 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

126 (302.07633972168): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

127 (!!!!! 22051.095962524): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

128 (604.86793518066): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737314 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737314 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 9023.1895446777): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (113.96408081055): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (65.803527832031): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (363.11149597168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (33.140182495117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (556.94580078125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (362.15782165527): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (40.054321289062): SELECT name FROM jos_deeppockets WHERE id=211

142 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=211

143 (572.91984558105): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (570.05882263184): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

146 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

147 (!!!!! 10468.95980835): TRUNCATE TABLE jos_trademed_module

148 (149.96528625488): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (76.055526733398): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737314 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (706.91108703613): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

153 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

154 (!!!!! 1636.9819641113): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

155 (105.14259338379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

156 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

157 (68.187713623047): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737314 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737314 AND type='deeppockets_item' AND published='1' LIMIT 1

158 (52.928924560547): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (43.153762817383): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (47.922134399414): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

161 (173.09188842773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

162 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737314 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737314 AND published='1' LIMIT 1

163 (39.100646972656): select jos_twitters.link from jos_twitters where cat=10

164 (28.133392333984): select jos_facebook.link from jos_facebook where cat=10

165 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

166 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

167 (283.00285339355): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

168 (!!!!! 1109.8384857178): insert into jos_banners_delta values (14615,'2025-08-20 00:18:25','216.73.216.0','view'),(14202,'2025-08-20 00:18:25','216.73.216.0','view'),(14203,'2025-08-20 00:18:25','216.73.216.0','view')

Click for LinkXpress Reader Inquiry Service
Enter code to receive information:

Where I can find code?

LinkXpress

Download Mobile App

Video Library

Featured Links

X-Ray Protein Probe May Lead to Potential Anticancer Treatment

Latest Radiography News

Channels

MedImaging

Channels

Features

Partner Sites

Archive: