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3D Imaging Test Developed for Managing Lung Cancer Screen False-Positives

By MedImaging International staff writers
Posted on 19 Jul 2011

A landmark 53,000-person study demonstrated that low-dose computed tomography (CT) screening of high-risk individuals decreases lung cancer deaths by 20%. More...

However, CT scans generate high rates of false-positive findings--nearly one in four--requiring invasive, expensive follow-up. A new noninvasive three-dimensional (3D) imaging test can identify early stage lung cancer cells in sputum with high sensitivity and specificity.

VisionGate, Inc. (Phoenix, AZ, USA), a company developing a revolutionary noninvasive test for the early detection of lung cancer, recently presented data showing how adjunctive use of its LuCED test can improve the utility of low dose X-ray computed tomography (CT) screening for the early detection of lung cancer in high risk individuals. LuCED uses VisionGate’s innovative automated 3D cell imaging platform, the Cell-CT, which generates high-resolution 3D biosignatures from intact cells using a sputum sample. The data were presented at the International Association for the Study of Lung Cancer’s 14th World Conference on Lung Cancer on July 7, 2011, held in Amsterdam, The Netherlands.

The proposed first use of LuCED as an adjunct to CT screening reflects the results of the US National Cancer Institute’s (NCI; Bethesda, MD, USA) landmark National Lung Screening Trial (NLST) of more than 53,000 current and former heavy smokers, which revealed that low-dose helical CT screening reduced lung cancer deaths by 20% compared to standard chest X-rays. These findings were first presented November 2010 and were expanded in the June 29, 2011, online edition of the New England Journal of Medicine (NEJM).

The NLST findings are generating widespread interest in the broad use of CT screening as a way to reduce lung cancer deaths in high-risk populations. However, the utility of the approach is hampered by the high rate of false positive results seen in the study--according to the NCI, more than 96% of the positive findings from low-dose CT screening over three rounds of testing turned out to be false-positive findings, representing almost a quarter (23.3%) of the overall test results. These false-positive test results require follow-up care that results in unnecessary invasive procedures for many patients and considerably higher costs for the healthcare system as a whole, potentially jeopardizing the feasibility of implementing mass screening programs for the millions of individuals at high risk for lung cancer.

In its presentation, VisionGate showed how LuCED harnesses the power of 3D imaging to detect cancer cells accurately when present in sputum samples from individuals at high risk of lung cancer. The presentation outlined patient management protocols for the noninvasive and efficient use of LuCED as an adjunct to CT screening to confirm which cases are true positives and to lower significantly the number of cases which are false positives.

Dr. Claudia Henschke, a lung cancer researcher at the Biodesign Institute at Arizona State University (Phoenix, USA), who is also a practicing physician at Mount Sinai Medical Center (New York, NY, USA), serves as a leader of the International Early Lung Cancer Action Program. She is coauthor of a pioneering study of the benefits of CT scans for lung cancer that was published in NEJM in 2006.

Dr. Henschke noted, “Today, almost all patients diagnosed with lung cancer in the US die. The NLST study results released last November confirmed our initial findings showing that CT scans can find lung cancers in their earliest stage, when up to 92% can be cured. VisionGate’s LuCED technology has demonstrated promise as an approach that may increase the feasibility of implementing widespread screening of high risk individuals, initially being used as an adjunct to improve the accuracy of CT scan results, with the potential to be used as a primary screening tool if additional trials are successful. We look forward to the opportunity to contribute to assessments of its potential utility in helping to reduce the death rate from this lethal cancer that affects so many people around the globe.”

LuCED uses the company’s breakthrough automated Cell-CT platform to generate detailed 3D images of the cells contained in sputum samples, which the system analyzes to identify key features associated with potential malignancy. The analysis yields a score that indicates whether or not cancer cells are present in the sample. The Cell-CT system produces strikingly clear and comprehensive 3D images of the cells, enabling extremely accurate classifications. VisionGate researchers estimate that LuCED will be able to achieve specificity of 99% and sensitivity of 75% in actual use.

“The dramatic results of the NLST study provide us with a valuable initial indication for our LuCED test,” commented Scarlett Spring, president of VisionGate. “By combining the high accuracy and cost effectiveness of our noninvasive LuCED diagnostic with the proven ability of CT screening to reduce lung cancer deaths, we hope to make mass screening feasible and affordable. We believe that we have developed an efficient clinical and regulatory strategy for our proposed use of LuCED to manage the false-positive results from CT screening, and we look forward to advancing this program in the coming months.”

Prior to the development of LuCED, a number of studies had validated that analyzing cells in sputum could potentially be useful in the early detection of lung cancer, revealing that 85% of sputum samples from individuals with lung cancer (the samples were taken over three days and pooled) actually contained cancer cells. However, the typically poor sensitivity of raw sputum analysis and the labor-intensive nature of the process made it impracticable for widespread use in lung cancer screening. The Cell-CT platform’s 3D technology, combined with its advanced automated 3D image analysis algorithms, for the first time make a cell-based sputum analysis approach both logistically feasible and cost effective.

VisionGate is developing the noninvasive test for the early detection of lung cancer, using its automated 3D cell-imaging platform, the Cell-CT, which generates high-resolution 3D biosignatures from intact cells using a sputum sample. The company’s LuCED test is initially being developed for adjunctive use with low dose CT screening for the early detection of lung cancer in high-risk individuals. Adjunctive use of LuCED to manage better the high rate of false-positive results in CT screening could increase the utility and cost effectiveness of the approach, which has been shown to decrease lung cancer deaths in former and current smokers.

Related Links:
VisionGate
US National Cancer Institute

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52 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

53 (466.10832214355): SELECT name FROM jos_deeppockets WHERE id=294736149 LIMIT 1

54 (286.10229492188): SELECT name FROM jos_deeppockets_archive WHERE id=294736149 LIMIT 1

55 (45.061111450195): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

56 (82.015991210938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736149 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (617.02728271484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736149 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (!!!!! 1194.953918457): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

59 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

60 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

61 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

62 (141.85905456543): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

63 (551.93901062012): SELECT fid FROM jos_deeppockets WHERE id=294736149 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294736149 AND published='1' LIMIT 1

64 (52.928924560547): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

65 (42.915344238281): select jos_twitters.link from jos_twitters where cat=10

66 (34.093856811523): select jos_facebook.link from jos_facebook where cat=10

67 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

68 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

69 (49.114227294922): SELECT fid FROM jos_deeppockets WHERE id=294736149 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294736149 AND published='1' LIMIT 1

70 (46.968460083008): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

71 (373.84033203125): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736149 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (233.88862609863): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736149 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (59.843063354492): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (71.048736572266): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736149 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (30.994415283203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736149 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (36.954879760742): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (55.789947509766): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

106 (50.783157348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

107 (56.982040405273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736149 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (80.108642578125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736149 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

110 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

111 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294736149 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (570.05882263184): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294736149 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (520.94459533691): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (306.12945556641): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

116 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

117 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

118 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

119 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

120 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

121 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

122 (57.220458984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

123 (268.93615722656): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 18939.971923828): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (488.0428314209): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736149 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736149 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 7302.99949646): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (93.221664428711): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (71.048736572266): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (290.1554107666): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (32.186508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (529.05082702637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (364.06517028809): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (38.14697265625): SELECT name FROM jos_deeppockets WHERE id=211

139 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=211

140 (545.97854614258): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (452.99530029297): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

143 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

144 (!!!!! 11804.103851318): TRUNCATE TABLE jos_trademed_module

145 (92.029571533203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736149 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (60.081481933594): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736149 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (787.97340393066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

150 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

151 (!!!!! 1245.0218200684): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

153 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

154 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736149 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736149 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

157 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (252.00843811035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

159 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736149 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736149 AND published='1' LIMIT 1

160 (54.121017456055): select jos_twitters.link from jos_twitters where cat=10

161 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

162 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

163 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

164 (385.04600524902): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

165 (!!!!! 1106.9774627686): insert into jos_banners_delta values (14615,'2025-08-20 03:17:09','216.73.216.0','view'),(14202,'2025-08-20 03:17:09','216.73.216.0','view'),(14203,'2025-08-20 03:17:09','216.73.216.0','view')

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3D Imaging Test Developed for Managing Lung Cancer Screen False-Positives

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