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Dual Approach Gives a More Effective Image of Autistic Brain

By MedImaging International staff writers
Posted on 24 May 2010

A first of its kind study combines two complementary analytic brain imaging techniques to provide a more comprehensive and precise picture of the neuroanatomy of the autistic brain.

The study, published in the April 2010 issue of the neuroimaging journal Human Brain Mapping, was conducted by researchers from the Montreal Neurological Institute and Hospital, The Neuro Institute, both at McGill University (Montreal, Canada), and the Université de Montréal (Canada). The findings provide vital insights into autism and possible markers for the disease for use in early therapy and therapeutic strategies.

Autism is a complex spectrum disorder thought to affect 1 in 166 people. Autistic individuals have difficulties with social interaction, communication, and repetitive behaviors, which can lead to isolation and emotional problems. They may also have enhanced abilities, particularly in auditory and visual perception.

Although structural brain differences have been reported in autism, the reports are inconsistent. The Neuro research team's goal, therefore, was to investigate neuroanatomic differences using a dual-analytic approach, combining cortical thickness analysis (CT) and voxel-based morphometry (VBM) together for the first time in the same participants. The investigators examined a group of young adults with autism of average intelligence and similar language ability relative to closely matched typically developing controls.

"The findings are significant from a functional perspective because the anatomical differences are found in brain regions known to play a functional role in the core features of autism such as social communication and repetitive behaviors, according to Dr. Krista Hyde, research fellow with Dr. Alan Evans at The Neuro, and lead investigator in the study. "This is the first step to looking for clues or markers that would help us correlate structural differences with functional and behavioral characteristics.”

The advantage in analyzing brain anatomy using CT and VBM is the complementary nature of the two methods, which in combination provide a direct measure of cortical grey matter, regions of the brain that consist primarily of nerve cell bodies. The combined method also provides a measure of subcortical gray matter as well as white matter, regions of the brain composed primarily of nerve cell fibers, which have myelin sheaths. "The converging results found from CT and VBM analysis, allows us to make more confident interpretations about the structural brain differences found in autism,” added Dr. Hyde.

Regional differences in gray matter were found in socially relevant and communication-related brain areas, as well as in areas implicated in repetitive behaviors and those found to play a role in empathic behavior. The study also identifies gray matter increases in autism in the visual cortex and for the first time, in the primary auditory cortex. "We believe that the visual and auditory cortical thickness increases may be related to enhanced visual and auditory perception in autism.”

"These new results are extremely important because they offer a more accurate picture of the autistic brain, helping researchers improve early autism treatment strategies,” said Dr. Anthony Phillips, scientific director of the Canadian Institutes of Health Research (CIHR; Ottawa, Ontario) Institute of Neurosciences, Mental Health and Addiction. "Autism rates have been rising steadily in Canada, so CIHR is proud to support researchers who devote their time to look into this neurological condition.”

The study's findings provide, according to the investigators, key insights into autism by identifying structural differences in functionally relevant areas of the brain in a group of individuals with autism using a dual analytic approach for the first time.

Related Links:
Montreal Neurological Institute and Hospital
The Neuro Institute
Université de Montréal

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62 (487.08915710449): SELECT fid FROM jos_deeppockets WHERE id=294729469 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294729469 AND published='1' LIMIT 1

63 (279.90341186523): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (45.061111450195): select jos_twitters.link from jos_twitters where cat=10

65 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

66 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.802322387695): select jos_linkedin.link from jos_linkedin where cat=10

68 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE id=294729469 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294729469 AND published='1' LIMIT 1

69 (30.994415283203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (274.1813659668): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (211.00044250488): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (36.954879760742): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (54.836273193359): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (56.982040405273): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

105 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

106 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

109 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

110 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294729469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (467.06199645996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294729469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (524.99771118164): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (316.85829162598): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

115 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

116 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

117 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

118 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

119 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

120 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

121 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

122 (396.0132598877): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 23190.975189209): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (581.02607727051): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729469 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729469 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 8439.0640258789): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (101.08947753906): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (289.9169921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 5920.1717376709): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (65.088272094727): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (391.00646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (270.84350585938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 1121.0441589355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (468.01567077637): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (688.79127502441): SELECT name FROM jos_deeppockets WHERE id=211

138 (134.94491577148): SELECT name FROM jos_deeppockets WHERE id=211

139 (613.21258544922): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (813.00735473633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (669.00253295898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

142 (400.06637573242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

143 (!!!!! 17322.063446045): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1338.005065918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (401.02005004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (334.9781036377): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

149 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

150 (!!!!! 1646.0418701172): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (385.99967956543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

152 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

153 (!!!!! 1307.9643249512): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729469 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729469 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (36.954879760742): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (280.14183044434): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (643.01490783691): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

158 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729469 AND published='1' LIMIT 1

159 (54.121017456055): select jos_twitters.link from jos_twitters where cat=10

160 (29.802322387695): select jos_facebook.link from jos_facebook where cat=10

161 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

162 (199.79476928711): select jos_linkedin.link from jos_linkedin where cat=10

163 (341.89224243164): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1088.8576507568): insert into jos_banners_delta values (14615,'2025-06-28 05:43:22','216.73.216.249','view'),(14202,'2025-06-28 05:43:22','216.73.216.249','view'),(14203,'2025-06-28 05:43:22','216.73.216.249','view')

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