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Adding Noise Shown to Improve Mammogram Accuracy

By MedImaging International staff writers
Posted on 18 Jan 2010

A research team has shown that an obscure phenomenon called stochastic resonance (SR) can improve the clarity of signals in systems such as radar, sonar, and even radiography used in medical clinics to detect signs of breast cancer. It does this by adding carefully selected noise to the system.

The result has been a distinct improvement in the system's ability to correctly identify precancerous lesions, plus a 36 percent reduction in false-positives. The inventors have developed an innovative method of calculating precisely the correct type and level of noise to add to existing noise in radiography or a similar system. "We see a broad spectrum of applications for this technology,” stated research assistant Prof. Hao Chen, from Syracuse University (SU; NY USA). "If a system's performance is unsatisfactory, we add noise to the system based on a specific algorithm that can significantly improve system performance.”

A patent covering the technology has been issued to Prof. Chen, Prof. Pramod K. Varshney and research professor James Michels. All are associated with SU's L.C. Smith College of Engineering and Computer Science.

In mammography studies conducted by doctoral candidate Renbin Peng, the challenge was to identify clusters of microcalcifications in breast tissue. These early signs of precancerous conditions average only 0.3 mm in size and offer only slight contrast with surrounding tissue. In addition to improving detection of these lesions, the researchers have reduced false positives by more than one-third.

While the current focus of the research group is on medical uses of stochastic resonance, other applications are expected in enhancing audio, video, geophysical, environmental, radar, and other signals. The group has been receiving support from the U.S. Air Force Office of Scientific Research. Ongoing investigations by the Syracuse group are expected to produce further improvements in the efficiency and robustness of the SR-based detection techniques.

An article by the inventors on the theory of stochastic resonance effect in signal detection was published by IEEE Transactions in Signal Processing in July 2007. Another article, covering the mammography studies, coauthored by Mr. Peng, was published in IEEE Journal of Selected Topics in Signal Processing in February 2009.

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68 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE id=294727475 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294727475 AND published='1' LIMIT 1

69 (33.140182495117): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (315.90461730957): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294727475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (216.96090698242): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294727475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (40.054321289062): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 3274.9176025391): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (792.9801940918): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (226.97448730469): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 1057.8632354736): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (178.09867858887): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 3211.9750976562): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (!!!!! 2113.1038665771): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 3123.9986419678): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294727475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (!!!!! 7847.785949707): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294727475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (780.82084655762): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (574.11193847656): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 1745.9392547607): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 1888.9904022217): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (!!!!! 4035.9497070312): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (100.13580322266): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (120.16296386719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

105 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

106 (60.796737670898): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (498.05641174316): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

109 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

110 (102.99682617188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294727475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (649.92904663086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294727475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (833.98818969727): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (712.87155151367): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

115 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

116 (96.797943115234): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

117 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

118 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

119 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

120 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

121 (55.789947509766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

122 (455.85632324219): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 59170.007705688): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (524.99771118164): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294727475 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294727475 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (53.882598876953): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (38.14697265625): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (76.055526733398): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 3389.1201019287): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 3530.0254821777): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (106.0962677002): SELECT name FROM jos_deeppockets WHERE id=211

138 (110.86463928223): SELECT name FROM jos_deeppockets WHERE id=211

139 (968.93310546875): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (833.98818969727): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (122.7855682373): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

142 (96.797943115234): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

143 (!!!!! 14770.984649658): TRUNCATE TABLE jos_trademed_module

144 (94.890594482422): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 3250.8373260498): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

149 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

150 (!!!!! 1286.0298156738): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

152 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

153 (37.908554077148): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294727475 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294727475 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (786.06605529785): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

158 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727475 AND published='1' LIMIT 1

159 (77.009201049805): select jos_twitters.link from jos_twitters where cat=10

160 (33.140182495117): select jos_facebook.link from jos_facebook where cat=10

161 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

162 (32.901763916016): select jos_linkedin.link from jos_linkedin where cat=10

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