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In Vivo Imaging Technology Integrates Fluorescence, Bioluminescence, and X-Ray Modalities

By MedImaging International staff writers
Posted on 25 Sep 2009

New technology combines highly sensitive bioluminescence and fluorescence molecular optical imaging with the anatomic accuracy of digital X-ray. Integrating these three imaging modalities provides researchers with additional capabilities to explore the molecular basis of disease and determine the response to drug therapies.

Caliper Life Sciences, Inc. (Hopkinton, MA, USA), a provider of tools and services for drug discovery and life sciences research, introduced the IVIS Lumina XR in vivo imaging system, the latest addition to the IVIS product range. Caliper's noninvasive IVIS preclinical molecular optical imaging technology is an innovative research tool that has greatly advanced both basic scientific research as well as the novel breakthrough research necessary to develop safe new drugs.

To date, peer-reviewed publications show that IVIS technology has aided the discovery and development of five U.S. Food and Drug Administration (FDA)-approved therapies and more than nine drug compounds in development. The introduction of the Lumina XR system takes this innovation one step further by combining optical fluorescent and bioluminescent images of biologic activity with coregistered digital X-ray images, enhancing the anatomical context of the optical molecular signals. For example, with X-ray coregistration the researcher can view a detailed image of the skeleton, or even certain soft tissues, and can use those images as a reference point when using bioluminescence to more precisely locate a tumor or infection site in an animal.

"Caliper's bioluminescent and fluorescent IVIS imaging systems are well-recognized by researchers at top universities and pharmaceutical companies as the leading preclinical in vivo imaging solution," said Kevin Hrusovsky, president and chief executive officer, Caliper Life Sciences. "The demand for advanced preclinical imaging technologies continues to increase, and Caliper is meeting that demand by offering a multimodality solution that will enhance current research applications and further enable newer areas of research, including bone disease and arthritis. We remain committed to providing scientists with valuable tools that translate experimentation into viable clinical options."

All IVIS systems are optically capable of imaging the full spectrum of fluorescent and bioluminescent reporters and dyes, from green to near infrared, with quantitative results and high performance spectral unmixing, to extract maximum information from animal models. Lumina XR can incorporate the premium animal-handling features of Caliper's other IVIS imaging systems, such as a heated stage, gas anesthesia connections, and a syringe injection system for simultaneous compound administration. In addition to mice, the Lumina XR can accommodate Petri dishes or microtiter plates for in vitro imaging. Similar to Caliper's other IVIS imaging systems, the Lumina XR will serve a wide array of therapeutic areas, including cancer research, infectious disease, inflammation, metabolic disease, neurology, cardiovascular disease, toxicology, and other applications.

Caliper Life Sciences is a provider of technologies enabling researchers in the life sciences industry to create life-saving and enhancing medicines and diagnostic tests more quickly and efficiently. Caliper's range of products includes microfluidics, lab automation and liquid handling, optical imaging technologies, and discovery and development outsourcing solutions.

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64 (60.081481933594): select jos_twitters.link from jos_twitters where cat=10

65 (42.915344238281): select jos_facebook.link from jos_facebook where cat=10

66 (43.869018554688): select jos_google_plus.link from jos_google_plus where cat=10

67 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

68 (46.968460083008): SELECT fid FROM jos_deeppockets WHERE id=294725570 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294725570 AND published='1' LIMIT 1

69 (44.107437133789): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (406.98051452637): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (257.96890258789): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (60.081481933594): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (40.054321289062): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 5592.8230285645): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (133.03756713867): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (143.05114746094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

105 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

106 (76.055526733398): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (617.98095703125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (111.81831359863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

109 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

110 (52.213668823242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (603.91426086426): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (621.08039855957): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (943.89915466309): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (535.96496582031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

115 (249.86267089844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

116 (183.10546875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

117 (473.0224609375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

118 (421.04721069336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

119 (183.10546875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

120 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

121 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

122 (476.12190246582): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 64759.016036987): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (730.03768920898): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725570 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725570 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (85.115432739258): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (52.213668823242): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (70.810317993164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (68.902969360352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (62.942504882812): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (490.18859863281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (380.9928894043): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (54.836273193359): SELECT name FROM jos_deeppockets WHERE id=211

138 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=211

139 (763.1778717041): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (926.01776123047): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

142 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

143 (!!!!! 9458.7802886963): TRUNCATE TABLE jos_trademed_module

144 (163.79356384277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (92.029571533203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (541.92543029785): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (86.784362792969): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

149 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

150 (!!!!! 1529.9320220947): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

152 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

153 (96.08268737793): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725570 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725570 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (41.007995605469): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (47.922134399414): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 3432.9891204834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

158 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725570 AND published='1' LIMIT 1

159 (64.13459777832): select jos_twitters.link from jos_twitters where cat=10

160 (50.783157348633): select jos_facebook.link from jos_facebook where cat=10

161 (35.04753112793): select jos_google_plus.link from jos_google_plus where cat=10

162 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

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