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MDCT and Leukotriene Inhibitor May Reduce Unstable Coronary Plaques

By MedImaging International staff writers
Posted on 08 Jun 2009

The results of a substudy of patients in an acute coronary syndrome (ACS) phase II trial who received serial 64-slice multidetector computed tomography (MDCT) scans before and after six months of treatment with a new drug, VIA-2291, an inhibitor of leukotrienes, (proposed mediators of vascular inflammation) demonstrated a reduction in noncalcified plaque volume and fewer new plaque lesions in treated patients.

Results of the study were presented at the American Heart Association Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) annual conference 2009 in Washington DC, USA, in May 2009, by Jean-Claude Tardif, M.D., of the Montreal Heart Institute (QC, Canada), and Dr. Rebecca Taub, VIA Pharmaceuticals, Inc. (San Francisco, CA, USA), senior vice president, research and development. VIA developed VIA-2291.

Of 191 patients enrolled in the first 12 weeks of the ACS trial, over 85 elected to continue in the study for an additional 12 weeks, receiving either placebo or VIA-2291 on top of current standard medical care. Each of these patients received an MDCT scan at baseline and at 24 weeks. Evaluable scans from patients treated with placebo showed significantly more evidence of new plaque lesions at follow-up than VIA-2291 treated patients. MDCT scans of patients with low-density plaques demonstrated statistically significant, lower plaque volumes in combined VIA-treated groups compared to placebo. Combined, these findings suggest that VIA-2291 may reduce the progression of unstable coronary plaques that lead to heart attacks and stroke.

In spite of recent advances in treatment, cardiovascular disease remains a leading cause of death and disability in the United States and the world. Emerging research points to the potential for inflammation within the vascular wall to be a key contributing factor in major adverse cardiac events (MACE) such as heart attack or stroke. This ACS substudy is the first clinical trial to use MDCT imaging to assess the effects of a drug on coronary plaque in a large patient cohort. MDCT is a state-of-the-art imaging technology that enables noninvasive imaging of coronary vessels.

"This innovative imaging technology has, for the first time, allowed us to visually and noninvasively demonstrate a reduction in plaque volume and a reduced number of new plaque lesions,” said Dr. Jean-Claude Tardif, director of the Montreal Heart Institute Research Center, professor of medicine at the University of Montreal and lead investigator of the VIA-2291 ACS trial. "In the ACS study results presented in 2008, we discussed VIA-2291's ability to reduce high sensitivity C-reactive protein [hs-CRP], a biomarker for inflammation. Taken as a whole, these results are an important step forward in understanding the importance of one cardiovascular inflammatory pathway.”

"VIA-2291 continues to show a significant effect on vascular inflammation, and these data add to the weight of the evidence from our phase II trial program,” said Lawrence K. Cohen, Ph.D., chief executive officer of VIA. "We have now combined histology, non-invasive imaging, and biomarker data to demonstrate the impact of VIA-2291. This adds support to our clinical development efforts and gives us even greater confidence as we look to move into a larger trial.”

VIA Pharmaceuticals is a biotechnology company focused on the development of compounds for the treatment of cardiovascular and metabolic disease. VIA's lead candidate, VIA-2291, targets a significant unmet medical need: reducing inflammation in the blood vessel wall, which is an underlying cause of atherosclerosis and its complications, including heart attack and stroke. Moreover, VIA's pipeline of drug candidates includes other compounds to address other underlying causes of cardiovascular disease: high cholesterol, diabetes and inflammation.

Related Links:
Montreal Heart Institute
VIA Pharmaceuticals

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60 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

61 (!!!!! 1441.0018920898): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (826.83563232422): SELECT fid FROM jos_deeppockets WHERE id=294723469 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294723469 AND published='1' LIMIT 1

63 (248.90899658203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (!!!!! 1282.2151184082): select jos_twitters.link from jos_twitters where cat=10

65 (38.862228393555): select jos_facebook.link from jos_facebook where cat=10

66 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

67 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

68 (340.93856811523): SELECT fid FROM jos_deeppockets WHERE id=294723469 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294723469 AND published='1' LIMIT 1

69 (150.20370483398): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (!!!!! 1080.0361633301): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (195.02639770508): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (365.9725189209): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (102.99682617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (182.8670501709): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (149.96528625488): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (165.93933105469): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (93.936920166016): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (109.91096496582): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (89.883804321289): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (69.856643676758): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (96.08268737793): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (69.141387939453): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (317.81196594238): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (121.8318939209): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (88.930130004883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (218.86825561523): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (391.00646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (173.09188842773): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (98.943710327148): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (74.863433837891): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (95.129013061523): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (93.936920166016): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (92.029571533203): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (93.936920166016): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (409.84153747559): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (741.95861816406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

105 (153.0647277832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

106 (176.90658569336): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (951.05171203613): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1952.8865814209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

109 (188.11225891113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

110 (932.21664428711): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294723469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (572.91984558105): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294723469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 7630.1097869873): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 3031.0153961182): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (943.18389892578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

115 (!!!!! 3806.8294525146): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

116 (!!!!! 7667.064666748): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

117 (!!!!! 2755.1651000977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

118 (730.99136352539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

119 (222.92137145996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

120 (!!!!! 2382.0400238037): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

121 (391.00646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

122 (173.09188842773): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 187703.13262939): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 10827.06451416): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723469 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723469 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1939.058303833): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (43.869018554688): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (802.99377441406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (886.91711425781): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (207.90100097656): SELECT name FROM jos_deeppockets WHERE id=211

138 (136.8522644043): SELECT name FROM jos_deeppockets WHERE id=211

139 (!!!!! 4260.0631713867): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (944.13757324219): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (422.00088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

142 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

143 (!!!!! 19866.943359375): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 7090.0917053223): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723469 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 4509.9258422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 1847.0287322998): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

149 (375.98609924316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

150 (!!!!! 3279.9243927002): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 6773.9486694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

152 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

153 (410.07995605469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723469 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723469 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (!!!!! 3103.0178070068): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (128.03077697754): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (330.20973205566): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (110.14938354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

158 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723469 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723469 AND published='1' LIMIT 1

159 (!!!!! 3590.1069641113): select jos_twitters.link from jos_twitters where cat=10

160 (114.91775512695): select jos_facebook.link from jos_facebook where cat=10

161 (!!!!! 3895.0443267822): select jos_google_plus.link from jos_google_plus where cat=10

162 (120.87821960449): select jos_linkedin.link from jos_linkedin where cat=10

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