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Targeted Microsphere Treatment for Liver Cancer Shows Promise

By MedImaging International staff writers
Posted on 01 Jun 2009

An innovative treatment for inoperable liver cancer delivers high doses of radiation directly to the site of tumors is extending and improving the quality of life of patients. Known as selective internal radiation therapy (SIRT), this innovative treatment uses millions of microscopic radioactive beads referred to as SIR-Spheres, delivered via catheter, to target primary and metastic liver cancer while largely sparing healthy tissue.

Dr. Seza Gulec, a Florida International University (FIU) College of Medicine (Miami, FL, USA) professor of surgery and radiology/nuclear medicine, is a leading researcher in the development of this treatment and was the first in the United States to use SIRT in combination with chemotherapy for the treatment of liver cancers. "We are essentially using the tumors' blood supply to kill them, by infusing them with beta radiation through the targeted delivery of yttrium 90 resin microspheres,” said Dr. Gulec, who has continued to advance this radiomicrosphere therapy for liver cancer since joining FIU College of Medicine in August 2008. "With this approach, we are able to use a much higher dose of radiation to effectively reduce the size and activity of cancer tumors in the liver. From my experience of treating more than 200 patients, all have responded positively to this treatment with some patients leading longer lives.”

Clinical trials have confirmed that liver cancer patients treated with SIR-Spheres microspheres have response rates higher than those with other forms of treatment. In a recently completed clinical trial, reported on in May 2009 in the Journal of Nuclear Medicine (JNM), SIRT combined with chemotherapy was shown to be superior to chemotherapy alone in patients with colorectal cancer liver metastases.

"Of the nearly 150,000 Americans diagnosed with colorectal cancer every year, at least 60% will see their cancer spread to the liver,” said Dr. John Rock, founding dean and senior vice president for medical affairs for FIU College of Medicine. "That makes Dr. Gulec's advancements in the field of radiomicrosphere therapy an incredibly important step forward in cancer research.”

The new approach is also used to treat pancreatic cancer patients who have recurrent disease and liver metastases and incorporates SIRT. The safety and efficacy of combining systemic chemotherapy with SIRT and external beam TomoTherapy for surgically untreatable pancreatic cancer was recently reported in the Journal of Interventional Oncology (JIO).

"It is essential that we continue conducting clinical trials combining SIRT with chemotherapy and other liver-directed treatment modalities to perfect this treatment,” Dr. Gulec stated. "Radiomicrosphere therapy is increasingly considered earlier in the course of treatment as opposed to a last resort. But, there is also a need for the development of more uniform patient selection criteria for treatment planning and execution.”

In the fall of 2008, Dr. Gulec and his team of FIU researchers, based at Jackson North Medical Center (Miami. FL, USA), were the first in the United States to begin implementing an advanced three-modality/three-dimensional treatment planning for SIRT. Since the U.S. Food and Drug Administration (FDA) granted SIR-Spheres microspheres premarket approval in March 2002, more than 1,800 treatments have been performed at more than 50 U.S.-based oncology centers, reported Sirtex (Wilmington, MA, USA), developer of the SIR-Spheres.

Related Links:
Florida International University College of Medicine
Sirtex

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60 (665.90309143066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

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62 (!!!!! 1177.0725250244): SELECT fid FROM jos_deeppockets WHERE id=294723402 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294723402 AND published='1' LIMIT 1

63 (332.83233642578): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

64 (!!!!! 1981.9736480713): select jos_twitters.link from jos_twitters where cat=10

65 (239.84909057617): select jos_facebook.link from jos_facebook where cat=10

66 (833.03451538086): select jos_google_plus.link from jos_google_plus where cat=10

67 (248.90899658203): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 3254.8904418945): SELECT fid FROM jos_deeppockets WHERE id=294723402 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294723402 AND published='1' LIMIT 1

69 (72.002410888672): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (!!!!! 1762.1517181396): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723402 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (860.92948913574): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723402 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (92.029571533203): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (100.13580322266): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (80.108642578125): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723402 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (215.05355834961): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723402 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (505.92422485352): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

105 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

106 (61.03515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723402 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (63.896179199219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723402 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

109 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

110 (48.160552978516): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294723402 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (546.93222045898): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294723402 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (468.96934509277): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (410.07995605469): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

115 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

116 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

117 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

118 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

119 (50.783157348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

120 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

121 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

122 (185.01281738281): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 154340.98243713): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 6682.8727722168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723402 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723402 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 6319.0460205078): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 1563.0722045898): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 1245.9754943848): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (48.160552978516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 2274.0364074707): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (80.82389831543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (57.93571472168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (418.90144348145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (337.12387084961): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (49.829483032227): SELECT name FROM jos_deeppockets WHERE id=211

138 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=211

139 (654.93583679199): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (617.98095703125): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 3576.9939422607): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

142 (!!!!! 7019.9966430664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

143 (!!!!! 14776.945114136): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1223.087310791): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723402 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (823.02093505859): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723402 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (458.95576477051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 1287.9371643066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 1538.9919281006): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

149 (!!!!! 3306.1504364014): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

150 (!!!!! 3406.0478210449): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (667.09518432617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

152 (375.03242492676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

153 (!!!!! 4425.048828125): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723402 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723402 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (!!!!! 1272.9167938232): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (257.96890258789): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 1795.0534820557): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

158 (!!!!! 3992.7959442139): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723402 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723402 AND published='1' LIMIT 1

159 (370.02563476562): select jos_twitters.link from jos_twitters where cat=10

160 (786.06605529785): select jos_facebook.link from jos_facebook where cat=10

161 (383.13865661621): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

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