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Brain Scans Show Young Adults at Future Risk of Alzheimer's have Different Brain Activity

By MedImaging International staff writers
Posted on 05 May 2009
Young adults with a genetic variant that increases their risk of developing Alzheimer's disease (AD) show changes in their brain activity decades before any symptoms might arise, according to a recent brain imaging study. The study's findings may support the hypothesis that the brain's memory function may gradually wear itself out in those who go on to develop AD.

Scientists from the University of Oxford (UK) and Imperial College London (UK) utilized functional magnetic resonance imaging (fMRI) scans on 36 healthy volunteers between the ages of 20 and 35, 18 of whom carried at least one copy of the APOE4 gene.

One-quarter of the wider population have the APOE4 genetic variant, which increases by up to four times the normal risk of developing Alzheimer's later in life, while those with two copies of the gene are at up to 10 times the normal risk. The study, published in the April 7, 2009, issue of the journal Proceedings of the [U.S.] National Academy of Sciences (PNAS), is the first to show hyperactivity in the hippocampus area of the brains of healthy young carriers of APOE4.

Rebecca Wood, chief executive of the Alzheimer's Research Trust (Cambridge, UK), said, "This significant development takes us a step closer to accurately predicting who will develop Alzheimer's before any symptoms become apparent. However, we are not yet at that stage; those with the APOE4 genetic variant--while at a statistically higher risk of developing the disease than others--will still not develop Alzheimer's in most cases. The causes of Alzheimer's are complex--both genetic and environmental--and if we can understand these better, we can enhance efforts to help people lower their risks. We can reduce our risk of developing dementia by maintaining a balanced diet, exercising regularly, and keeping our brains active, particularly through social activities. Alzheimer's and other dementias affect 700,000 people in the UK, costing our economy GBP 17 billion annually. Much more research is needed if we are to stop these figures from spiraling."

Dr. Clare Mackay, the lead author of the study from the department of psychiatry and the Center for Functional Magnetic Resonance Imaging of the Brain at the University of Oxford, said, "We have shown that brain activity is different in people with this version of the gene decades before any memory problems might develop. We've also shown that this form of fMRI, where people just lie in the scanner doing nothing, is sensitive enough to pick up these changes. These are exciting first steps towards a tantalizing prospect: a simple test that will be able to distinguish who will go on to develop Alzheimer's."

Dr. Christian Beckmann, another author of the study from the division of neurosciences and mental health at Imperial College London, added, "Our brains are always active--our minds wander even when we're not carrying out specific tasks. We were surprised to see that even when the volunteers carrying APOE4 weren't being asked to do anything, you could see the memory part of the brain working harder than it was in the other volunteers. Not all APOE4 carriers go on to develop Alzheimer's, but it would make sense if in some people, the memory part of the brain effectively becomes exhausted from overwork and this contributes to the disease. This theory is supported by studies that have found the opposite pattern in people who have developed Alzheimer's, with these people showing less activity than normal in the memory part of the brain."

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University of Oxford
Imperial College London


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91 (71.048736572266): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723062 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
92 (97.036361694336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
93 (560.99891662598): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (110.86463928223): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (113.96408081055): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (244.8558807373): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
105 (154.01840209961): SELECT show_live FROM jos_com_show_setting LIMIT 1
106 (360.96572875977): SELECT show_live FROM jos_com_show_setting LIMIT 1
107 (!!!!! 3301.1436462402): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
108 (560.99891662598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
109 (!!!!! 2042.0551300049): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723062 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
110 (99.897384643555): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723062 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
112 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
113 (123.02398681641): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294723062 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
114 (542.87910461426): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294723062 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
115 (557.89947509766): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
116 (330.92498779297): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
117 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
118 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
119 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
120 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
121 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
122 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
123 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
124 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
125 (309.94415283203): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
126 (!!!!! 20510.911941528): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
127 (554.08477783203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723062 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723062 AND type='deeppockets_item' AND published='1' LIMIT 1
128 (57.220458984375): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
129 (34.809112548828): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
130 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
131 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
132 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
133 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
134 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
135 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
136 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
137 (26.941299438477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
138 (487.8044128418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
139 (345.94535827637): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
140 (37.193298339844): SELECT name FROM jos_deeppockets WHERE id=211
141 (30.994415283203): SELECT name FROM jos_deeppockets WHERE id=211
142 (607.01370239258): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
143 (516.89147949219): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
144 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
145 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
146 (!!!!! 9334.0873718262): TRUNCATE TABLE jos_trademed_module
147 (133.99124145508): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723062 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
148 (63.896179199219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723062 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
149 (551.93901062012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
150 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
151 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
152 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
153 (!!!!! 1200.1991271973): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
154 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
155 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
156 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723062 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723062 AND type='deeppockets_item' AND published='1' LIMIT 1
157 (34.093856811523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
158 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
159 (33.140182495117): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
160 (78.201293945312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
161 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723062 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723062 AND published='1' LIMIT 1
162 (52.928924560547): select jos_twitters.link from jos_twitters where cat=10
163 (33.855438232422): select jos_facebook.link from jos_facebook where cat=10
164 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10
165 (32.186508178711): select jos_linkedin.link from jos_linkedin where cat=10