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Hormone Therapy Found to Compromise Breast Cancer Diagnosis

By MedImaging staff writers
Posted on 17 Mar 2008

A new US study found that women taking combined hormone therapy had an increased risk of otherwise avoidable abnormal mammograms and breast biopsies that compromised the ability of these two techniques to help diagnose breast cancer.

The study was conducted by Dr. Rowan T. Chlebowski, an investigator at the Los Angeles Biomedical Research Institute at Harbor-University of Los Angeles, California (UCLA) Medical Center (LA BioMed), and colleagues, and was published in the February 25, 2008, issue of the journal Archives of Internal Medicine.

Dr. Chlebowski reported that the findings "represent a concern for post-menopausal women who are considering hormone therapy.” The effect of combined hormone therapy on the detection of breast cancer has not been determined before, according to the investigators.

Dr. Chlebowski and colleagues studied 16,608 women enrolled in the 15-year Women's Health Initiative (WHI) clinical trial that started in 1993. The women were randomly assigned to two treatment groups: a hormone group and a placebo group. The hormone group received a combination of estrogen and progestin (equine estrogens at 0.625 mg per day and medroxyprogesterone acetate at 2.5 mg per day). The women underwent mammogram and breast exams at the beginning of the trial and annually thereafter. Breast biopsies were also performed if indicated from the clinical findings. The team then looked at the effect of the combined hormones on breast cancer detection over 5.6 years.

The findings of their study revealed that the hormone group had a higher frequency of mammograms with abnormalities compared with the placebo group (35 versus 25%). Women in the hormone group had a 4% greater risk of having a mammogram with abnormalities after one year and this risk was 11% after five years, compared to the women in the placebo group. There was a lower sensitivity for breast cancer detection and increased cumulative frequency of breast biopsy in the hormone group (10.0 versus 6.1%). Breast tumors were considerably increased and diagnosed at higher stages in the hormone group. Despite this, biopsies in the hormone group diagnosed cancer less frequently compared with the placebo group (14.8 versus 19.6%). When hormone therapy was stopped, the adverse effect on mammograms remained significantly different to that of placebo for at least 12 months after.

Dr. Chlebowski and colleagues concluded that "use of conjugated equine estrogens plus medroxyprogesterone acetate for approximately five years resulted in more than 1 in 10 and 1 in 25 women having otherwise avoidable mammogram abnormalities and breast biopsies, respectively, and compromised the diagnostic performance of both. This adverse effect on breast cancer detection should be incorporated into risk-benefit discussions with women considering even short-term combined hormone therapy.”

Dr. Chlebowski advised women considering hormone therapy to "take the results of this study into consideration and consult with their physicians before undergoing even short-term hormone therapy.”

He stated that the results were relevant for women just entering the menopause as well: "After discontinuation of combined hormone therapy, the adverse effects on mammogram and breast biopsy performance were seen even in younger women in the fifth decade of life.”

Related Links:
Los Angeles Biomedical Research Institute

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66 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10

67 (43.153762817383): select jos_linkedin.link from jos_linkedin where cat=10

68 (49.829483032227): SELECT fid FROM jos_deeppockets WHERE id=274800000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=274800000 AND published='1' LIMIT 1

69 (36.954879760742): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

70 (317.09671020508): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=274800000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (346.18377685547): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=274800000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1272.2015380859): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (75.101852416992): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=274800000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=274800000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (33.855438232422): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

105 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

106 (71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=274800000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=274800000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

109 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

110 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=274800000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (656.8431854248): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=274800000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (569.10514831543): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (329.97131347656): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

115 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

116 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

117 (37.193298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

118 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

119 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

120 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

121 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

122 (298.97689819336): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 20609.855651855): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (612.02049255371): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=274800000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=274800000 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7784.8434448242): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (79.870223999023): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (292.06275939941): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (279.90341186523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (205.03997802734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (121.11663818359): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (198.1258392334): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (476.12190246582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (347.13745117188): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (222.20611572266): SELECT name FROM jos_deeppockets WHERE id=211

138 (33.140182495117): SELECT name FROM jos_deeppockets WHERE id=211

139 (669.95620727539): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (560.04524230957): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (129.93812561035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

142 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

143 (!!!!! 8577.823638916): TRUNCATE TABLE jos_trademed_module

144 (108.95729064941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=274800000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (59.843063354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=274800000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (842.09442138672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (60.796737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

149 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

150 (!!!!! 1249.0749359131): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

152 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

153 (44.107437133789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=274800000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=274800000 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

156 (35.04753112793): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

158 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274800000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274800000 AND published='1' LIMIT 1

159 (93.936920166016): select jos_twitters.link from jos_twitters where cat=10

160 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

161 (27.894973754883): select jos_google_plus.link from jos_google_plus where cat=10

162 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

163 (225.78239440918): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (946.044921875): insert into jos_banners_delta values (14615,'2025-08-25 00:18:08','216.73.216.171','view'),(14202,'2025-08-25 00:18:08','216.73.216.171','view'),(14203,'2025-08-25 00:18:08','216.73.216.171','view')

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