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AI-Generated Synthetic Scarred Hearts Aid Atrial Fibrillation Treatment

By MedImaging International staff writers
Posted on 14 Apr 2025

Image: The diffusion model was trained on real LGE-MRI distributions and generated synthetic fibrosis distributions from Gaussian noise (Photo courtesy of Frontiers, DOI: 10.3389/fcvm.2025.1512356)

Atrial fibrillation (AF) is a common heart rhythm disorder, often linked to the development of fibrosis, which is the formation of scar tissue in the heart. This fibrosis typically arises due to aging, prolonged stress, or the AF condition itself. These areas of stiff, fibrous tissue can interfere with the heart's electrical system, leading to the irregular heartbeat characteristic of AF. Currently, the pattern and distribution of this scarring are assessed using specialized MRI scans known as LGE-MRI. The extent and location of fibrosis are critical factors that influence the effectiveness of AF treatments. A common treatment for AF is ablation, a procedure in which doctors intentionally create small, controlled scars to block abnormal electrical signals. However, success rates for ablation vary, and predicting the most effective approach for individual patients remains a significant challenge. Despite the promise of artificial intelligence (AI) in predicting treatment outcomes, its progress has been limited due to the lack of high-quality patient imaging data.

Researchers at Queen Mary University of London (QMUL, London, UK) have developed an AI tool designed to generate synthetic, yet medically accurate, models of fibrotic heart tissue. This innovation could assist in treatment planning for patients with AF. The study, published in Frontiers in Cardiovascular Medicine, has the potential to offer more personalized care for AF patients. Using an advanced diffusion model, the research team created synthetic fibrosis distributions that closely mirrored real patient data. When these AI-generated patterns were applied to 3D heart models and tested against various ablation techniques, the resulting predictions proved nearly as accurate as those derived from actual patient data.

One key advantage of this approach is that it ensures patient privacy while enabling researchers to explore a broader range of cardiac scenarios than traditional methods permit. The findings underscore AI's growing role as a supportive tool in clinical settings rather than a decision-making entity. Given that AF affects millions of people globally and that ablation procedures fail in about half of the cases, this technology could significantly reduce the need for repeat procedures. Moreover, the AI method addresses two important healthcare challenges: the limited availability of patient data and the ethical need to protect sensitive medical information.

“We’re very excited about this research as it addresses the challenge of limited clinical data for cardiac digital twin models,” said Dr. Caroline Roney of QMUL, lead author of the study. “Our key development enables large scale in silico trials and patient-specific modeling aimed at creating more personalized treatments for atrial fibrillation patients.”

“This isn't about replacing doctors' judgement,” added first author Dr. Alexander Zolotarev of QMUL. “It's about providing clinicians with a sophisticated simulator – allowing them to test different treatment approaches on a digital model of each patient's unique heart structure before performing the actual procedure.”

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67 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

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69 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

70 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

71 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

72 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

73 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (80.82389831543): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

77 (43.869018554688): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

78 (91.075897216797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (780.10559082031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

93 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

94 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804652 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

95 (!!!!! 3115.8924102783): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

96 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

97 (413.89465332031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804652 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

98 (541.92543029785): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804648 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

99 (761.03210449219): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

100 (540.97175598145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

101 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

102 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

103 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

104 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

105 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

106 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

107 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

108 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

109 (208.85467529297): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

110 (!!!!! 68928.003311157): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

111 (520.94459533691): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804652 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804652 AND type='deeppockets_item' AND published='1' LIMIT 1

112 (!!!!! 27135.133743286): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

113 (102.04315185547): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

114 (410.07995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

115 (71.048736572266): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

116 (221.01402282715): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

117 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

118 (140.90538024902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

119 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

120 (208.85467529297): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

121 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

122 (371.93298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

123 (205.99365234375): SELECT name FROM jos_deeppockets WHERE id=212

124 (52.928924560547): SELECT name FROM jos_deeppockets WHERE id=212

125 (802.04010009766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

126 (741.00494384766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

127 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

128 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

129 (!!!!! 16242.980957031): TRUNCATE TABLE jos_trademed_module

130 (127.07710266113): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804652 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

131 (!!!!! 3093.957901001): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

132 (140.90538024902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

133 (109.91096496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

134 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

135 (!!!!! 1571.8936920166): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

136 (138.0443572998): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

137 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

138 (170.94612121582): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804652 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804652 AND type='deeppockets_item' AND published='1' LIMIT 1

139 (54.121017456055): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

140 (47.922134399414): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

141 (69.856643676758): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

142 (941.99180603027): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

143 (136.13700866699): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804652 AND published='1' LIMIT 1

144 (110.86463928223): select jos_twitters.link from jos_twitters where cat=10

145 (42.915344238281): select jos_facebook.link from jos_facebook where cat=10

146 (42.915344238281): select jos_google_plus.link from jos_google_plus where cat=10

147 (40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10

148 (403.88107299805): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

149 (!!!!! 1287.9371643066): insert into jos_banners_delta values (14615,'2025-07-31 12:34:48','216.73.216.8','view'),(14202,'2025-07-31 12:34:48','216.73.216.8','view'),(14203,'2025-07-31 12:34:48','216.73.216.8','view')

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