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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

New Research Supports Routine Brain MRI Screening in Asymptomatic Late-Stage Breast Cancer Patients

By MedImaging International staff writers
Posted on 14 Feb 2025

Image: The new findings warrant brain MRI surveillance recommendations for neurologically asymptomatic stage IV breast cancer (Photo courtesy of 123RF)

Currently, screening for asymptomatic brain metastasis in stage IV breast cancer patients using brain MRIs is not recommended. The prevalence of asymptomatic brain metastasis is not well established. However, a new study has revealed that asymptomatic brain metastasis is more common in stage IV breast cancer patients than previously thought. Published in Neuro-Oncology, the study suggests that doctors may need to reassess the existing screening guidelines for detecting brain metastasis in patients who do not show symptoms.

The research, conducted by scientists at Moffitt Cancer Center (Tampa, FL, USA), focused on 101 asymptomatic patients diagnosed with stage IV breast cancer, including those with triple-negative, HER2-positive, and hormone receptor-positive/HER2-negative breast cancer. These patients underwent MRI scans to check for brain metastasis, with a follow-up MRI six months later if the initial scan showed no signs of cancer spread. Among the patients who completed the initial MRI, 14% were found to have brain metastasis.

The rates of metastasis varied by subtype: 18% in triple-negative breast cancer, 15% in HER2-positive breast cancer, and 10% in hormone receptor-positive/HER2-negative breast cancer. After the second MRI, the percentage of patients with brain metastasis increased to about 25% across all subtypes. Following the diagnosis of brain metastasis, patients received early treatment, which included adjustments to systemic therapy and the addition of local therapies.

“Our study suggests that asymptomatic brain metastasis is quite common in stage 4 breast cancer,” said Kamran Ahmed, M.D., associate member and section chief for Breast Radiation Oncology at Moffitt and principal investigator of the study. “Although larger studies are needed to confirm our findings, given the improvements in systemic and local therapies for breast cancer brain metastasis, the time may be appropriate to reconsider current guidelines that recommend against routine MRI surveillance in late stage breast cancer.

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88 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

91 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

92 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804036 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

94 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

95 (418.90144348145): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804036 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (565.0520324707): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (359.05838012695): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (75.817108154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

99 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

100 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

101 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

102 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

103 (37.193298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

104 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

105 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

106 (210.04676818848): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 39783.954620361): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (411.9873046875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804036 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804036 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 7218.8377380371): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (87.02278137207): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (278.94973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (155.21049499512): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (135.89859008789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (40.769577026367): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (128.03077697754): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (264.88304138184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (125.16975402832): SELECT name FROM jos_deeppockets WHERE id=212

121 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=212

122 (595.0927734375): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (503.0632019043): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

125 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

126 (!!!!! 7772.9225158691): TRUNCATE TABLE jos_trademed_module

127 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804036 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (830.88874816895): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

131 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

132 (!!!!! 1168.966293335): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

134 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

135 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804036 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804036 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (28.848648071289): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

137 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

138 (29.087066650391): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

140 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804036 AND published='1' LIMIT 1

141 (138.0443572998): select jos_twitters.link from jos_twitters where cat=10

142 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

143 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

144 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

145 (313.99726867676): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 1026.8688201904): insert into jos_banners_delta values (14615,'2025-06-21 03:09:03','216.73.216.120','view'),(14202,'2025-06-21 03:09:03','216.73.216.120','view'),(14203,'2025-06-21 03:09:03','216.73.216.120','view')

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