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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

New Model Improves Comparison of MRIs Taken at Different Institutions

By MedImaging International staff writers
Posted on 03 Mar 2025

Image: Researchers have come up with a better way to compare MRI images taken at different institutions (Photo courtesy of Adobe Stock)

Magnetic resonance imaging (MRI) plays a crucial role in medicine by offering detailed views of the internal structures of the body and providing valuable insights into various pathologies. However, inconsistencies in image acquisition protocols across different institutions create significant challenges in ensuring reliable and consistent interpretation, especially in multi-center research. To address this issue, a new study has introduced a method for modifying MRI scans from different hospitals, making them more comparable and enabling more accurate and dependable comparisons.

Harmonizing MRI results is a fundamental issue in both research and healthcare quality. Each medical facility, clinic, or research institution uses its own set of imaging protocols, equipment, and parameters, leading to variations in contrast, brightness, and other characteristics of the images. This variability presents a major challenge in clinical research, particularly when data from multiple research centers are combined. In a collaborative study led by researchers from Université de Montreal (Montreal, Canada), a new harmonization technique was developed, which involves three main steps. The first step is to create a model that learns how MRI images in the source domain.

Once the distribution of the source domain is understood, the next goal is to "re-format" MRI scans from other institutions to remove variations caused by differences in machine settings or parameter choices, while still maintaining patient-specific differences. Finally, when the model is applied to new images (for example, from an unfamiliar machine), it must adapt to ensure that the newly processed images continue to follow the learned distribution. To validate their approach, the researchers tested the harmonization method on MRI brain scans from databases in the United States, as well as from a neonatal imaging consortium developed with Australian researchers. These data were used for two key tasks: first, to segment brain images in both adults and newborns to verify if brain structures remained consistent after harmonization, and second, to estimate the brain age of newborns.

The study, published in Medical Image Analysis, demonstrated that this new technique outperforms existing harmonization methods, showcasing its versatility across various tasks and population groups. Notably, the method was successfully validated on MRI scans of a newborn’s brain with lesions—something that all other available models fail to handle since they are typically trained on images of healthy brains. Looking ahead, the researchers plan to apply this approach on a larger scale in future collaborations and studies, which will help improve the comparison and analysis of research data and further enhance the accuracy and reliability of medical diagnoses.

“Thanks to this model, we can now interpret data from several thousands of families and children who are monitored at various hospitals – data that come from different scanners," said Dr. Gregory Lodygensky, a clinical professor at Université de Montreal. "The analysis of these large cohorts in children and adults was hampered by the major harmonization problem, which has now been resolved.”

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82 (537.87231445312): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 3406.0478210449): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

91 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

92 (63.896179199219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804209 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (808.0005645752): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

94 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

95 (581.97975158691): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804209 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (810.86158752441): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (678.06243896484): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (200.03318786621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

99 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

100 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

101 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

102 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

103 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

104 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

105 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

106 (429.15344238281): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 22102.832794189): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (498.05641174316): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804209 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804209 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 6989.9559020996): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (91.791152954102): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (317.09671020508): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (211.95411682129): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (141.85905456543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (216.96090698242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (437.97492980957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (174.04556274414): SELECT name FROM jos_deeppockets WHERE id=212

121 (66.041946411133): SELECT name FROM jos_deeppockets WHERE id=212

122 (647.06802368164): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (702.85797119141): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (149.01161193848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

125 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

126 (!!!!! 9640.9320831299): TRUNCATE TABLE jos_trademed_module

127 (101.08947753906): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804209 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (643.96858215332): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

131 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

132 (!!!!! 1176.8341064453): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

134 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

135 (34.093856811523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804209 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804209 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

137 (27.179718017578): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

138 (29.802322387695): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (858.78372192383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

140 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804209 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804209 AND published='1' LIMIT 1

141 (113.01040649414): select jos_twitters.link from jos_twitters where cat=10

142 (26.941299438477): select jos_facebook.link from jos_facebook where cat=10

143 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

144 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

145 (319.00405883789): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 1131.0577392578): insert into jos_banners_delta values (14615,'2025-06-21 02:00:52','216.73.216.120','view'),(14202,'2025-06-21 02:00:52','216.73.216.120','view'),(14203,'2025-06-21 02:00:52','216.73.216.120','view')

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