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High Resolution Ultrasound Speeds Up Prostate Cancer Diagnosis

By MedImaging International staff writers
Posted on 25 Mar 2025

Image: microUS-guided biopsy can identify prostate cancer as effectively as MRI-guided biopsy (Photo courtesy of 123RF)

Each year, approximately one million prostate cancer biopsies are conducted across Europe, with similar numbers in the USA and around 100,000 in Canada. Most of these biopsies are performed using MRI images combined with conventional ultrasound, allowing urologists to directly target potential tumors for more accurate diagnoses. However, the process of MRI-guided biopsy involves two steps: first, an MRI scan, followed by an ultrasound-guided biopsy. This procedure requires multiple hospital visits and specialist radiological expertise to interpret the MRI images and align them with the ultrasound. Now, an international clinical trial has demonstrated that biopsies guided by high-resolution ultrasound are just as effective as those using MRI for diagnosing prostate cancer.

Known as micro-ultrasound, this technology is less expensive and easier to use compared to MRI. It could greatly accelerate diagnosis, reduce the need for multiple hospital visits, and free up MRI resources for other purposes, as per the findings of the trial led by researchers at the University of Toronto (Toronto, ON, Canada). Micro-ultrasound operates at a higher frequency than traditional ultrasound, providing three times the resolution, which captures detail comparable to MRI scans for targeted biopsies. Urologists and oncologists can quickly learn to use the technique and interpret the images, especially if they are already experienced with conventional ultrasound. Micro-ultrasound is not only cheaper to acquire and operate than MRI, but it could also allow imaging and biopsies to be completed in a single appointment, even in non-hospital settings.

The OPTIMUM trial is the first randomized study to compare micro-ultrasound (microUS)-guided biopsy with MRI-guided biopsy for prostate cancer detection. The trial involved 677 men who underwent biopsies at 19 hospitals across Canada, the USA, and Europe. Half of the participants had MRI-guided biopsies, a third received both microUS-guided biopsy followed by MRI-guided biopsy, and the remaining patients only had the microUS-guided biopsy. The results of the OPTIMUM trial were presented at the European Association of Urology Congress in Madrid and published in JAMA. The microUS technique was found to be as effective as MRI-guided biopsy, with nearly identical detection rates across all three groups. Even in the group that received both types of biopsies, microUS identified the majority of significant cancers. According to the researchers, the results of the OPTIMUM trial could have a similar transformative impact as the initial introduction of MRI technology.

“When MRI first emerged and you could image prostate cancer accurately for the first time to do targeted biopsies, that was a gamechanger. But MRI isn’t perfect. It’s expensive. It can be challenging to get access to it quickly. It requires a lot of experience to interpret properly. And it uses gadolinium which has some toxicity. Not all patients can have MRI, if they have replacement hips or pacemakers for example,” said Laurence Klotz, Professor of Surgery at the University of Toronto’s Temerty Faculty of Medicine and the Sunnybrook Chair of Prostate Cancer Research. “But we now know that microUS can give as good a diagnostic accuracy as MRI and that is also game changing. It means you can offer a one stop shop, where patients are scanned, then biopsied immediately if required. There’s no toxicity. There are no exclusions. It’s much cheaper and more accessible. And it frees up MRIs for hips and knees and all the other things they’re needed for.”

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76 (47.206878662109): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (76.770782470703): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

92 (!!!!! 2481.9374084473): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

93 (94.890594482422): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804445 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

94 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

95 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

96 (422.95455932617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804445 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

97 (365.9725189209): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804443 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

98 (787.01972961426): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

99 (498.05641174316): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

100 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

101 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

102 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

103 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

104 (52.213668823242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

105 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

106 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

107 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

108 (298.97689819336): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

109 (!!!!! 126138.92555237): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

110 (!!!!! 5218.0290222168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804445 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804445 AND type='deeppockets_item' AND published='1' LIMIT 1

111 (!!!!! 18126.010894775): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

112 (!!!!! 5408.0486297607): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

113 (343.08433532715): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

114 (82.015991210938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

115 (252.00843811035): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

116 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

117 (152.1110534668): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

118 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

119 (135.89859008789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

120 (80.108642578125): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

121 (337.83912658691): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

122 (124.21607971191): SELECT name FROM jos_deeppockets WHERE id=212

123 (74.863433837891): SELECT name FROM jos_deeppockets WHERE id=212

124 (746.9654083252): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

125 (632.04765319824): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

126 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

127 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

128 (!!!!! 6673.0976104736): TRUNCATE TABLE jos_trademed_module

129 (!!!!! 1920.9384918213): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804445 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

130 (465.15464782715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

131 (202.89421081543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

132 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

133 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

134 (!!!!! 1600.0270843506): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

135 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

136 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

137 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804445 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804445 AND type='deeppockets_item' AND published='1' LIMIT 1

138 (41.007995605469): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

139 (37.193298339844): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

140 (37.193298339844): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

141 (!!!!! 1410.961151123): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

142 (88.214874267578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804445 AND published='1' LIMIT 1

143 (147.10426330566): select jos_twitters.link from jos_twitters where cat=10

144 (33.855438232422): select jos_facebook.link from jos_facebook where cat=10

145 (38.862228393555): select jos_google_plus.link from jos_google_plus where cat=10

146 (!!!!! 3123.9986419678): select jos_linkedin.link from jos_linkedin where cat=10

147 (422.95455932617): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

148 (!!!!! 1304.8648834229): insert into jos_banners_delta values (14615,'2025-07-31 12:31:03','216.73.216.8','view'),(14202,'2025-07-31 12:31:03','216.73.216.8','view'),(14203,'2025-07-31 12:31:03','216.73.216.8','view')

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