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New Scan Method Shows Effects of Treatment on Lung Function in Real Time

By MedImaging International staff writers
Posted on 25 Dec 2024

Image: Lung function MRI showing measurements in lung transplant recipients (Photo courtesy of Newcastle University)

A new lung scanning technique has been developed that allows for real-time observation of how treatments affect lung function, enabling clinicians to assess the condition of transplanted lungs. This breakthrough could help doctors identify declines in lung function more quickly.

The method, developed by a team of researchers at Newcastle University (Newcastle upon Tyne, UK), allows experts to track how air moves in and out of the lungs in patients with asthma, chronic obstructive pulmonary disease (COPD), and who have undergone a lung transplant. The team published their findings in Radiology and JHLT Open, explaining their use of perfluoropropane, a special gas visible on an MRI scanner. Safe for patients to inhale and exhale, this gas helps reveal which areas of the lungs are receiving air. By using this technique, the team can identify which parts of the lungs are not properly ventilated and assess the extent of lung disease by measuring both well-ventilated and poorly ventilated regions.

The team demonstrated the effectiveness of the scans in patients with asthma or COPD, as detailed in their first paper in Radiology. This scanning method allows them to measure improvements in lung ventilation following treatments, such as the bronchodilator salbutamol. This finding suggests that the technique could be valuable for assessing new treatments for lung diseases in clinical trials. In another study, published in JHLT Open, the team applied the method to lung transplant recipients at Newcastle upon Tyne Hospitals NHS Foundation Trust. They refined the technique to measure lung function in transplant patients, which could improve the care and monitoring of these individuals. The sensitivity of the method enables early detection of lung function changes, allowing for quicker identification of lung problems and better patient care.

In their studies, the researchers scanned transplant recipients’ lungs as they breathed in and out, collecting MRI images that show how the gas reached different parts of the lungs. They examined patients with normal lung function as well as those experiencing chronic rejection, a common complication where the immune system attacks the transplanted lungs. In patients with chronic rejection, the scans revealed reduced air movement to the outer parts of the lungs, likely due to damage in the small airways, a hallmark of chronic lung allograft dysfunction. The researchers believe this scanning method holds promise for enhancing the clinical management of lung transplant recipients and patients with other lung diseases, providing an early, sensitive measurement of lung function that could lead to better treatment outcomes.

“We hope this new type of scan might allow us to see changes in the transplant lungs earlier and before signs of damage are present in the usual blowing tests,” said Professor Andrew Fisher, Professor of Respiratory Transplant Medicine at Newcastle Hospitals NHS Foundation Trust and Newcastle University, co-author of the study. “This would allow any treatment to be started earlier and help protect the transplanted lungs from further damage.”

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83 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

91 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

92 (76.055526733398): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803522 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

94 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

95 (563.14468383789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803522 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (760.07843017578): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (575.06561279297): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (159.97886657715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

99 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

100 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

101 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

102 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

103 (55.789947509766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

104 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

105 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

106 (404.83474731445): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 29670.000076294): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (707.86476135254): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803522 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803522 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 29958.009719849): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (98.943710327148): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (415.08674621582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (68.187713623047): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (341.89224243164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (70.095062255859): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (284.91020202637): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (447.98851013184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (149.01161193848): SELECT name FROM jos_deeppockets WHERE id=212

121 (40.054321289062): SELECT name FROM jos_deeppockets WHERE id=212

122 (725.03089904785): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (630.85556030273): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (83.208084106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

125 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

126 (!!!!! 7655.8589935303): TRUNCATE TABLE jos_trademed_module

127 (726.93824768066): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803522 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (519.99092102051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (145.91217041016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

131 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

132 (!!!!! 1639.1277313232): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

134 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

135 (267.98248291016): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803522 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803522 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (376.93977355957): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

137 (391.96014404297): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

138 (!!!!! 7879.9724578857): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (!!!!! 7529.0203094482): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

140 (!!!!! 5764.9612426758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803522 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803522 AND published='1' LIMIT 1

141 (746.9654083252): select jos_twitters.link from jos_twitters where cat=10

142 (46.014785766602): select jos_facebook.link from jos_facebook where cat=10

143 (39.815902709961): select jos_google_plus.link from jos_google_plus where cat=10

144 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

145 (!!!!! 1602.8881072998): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 2026.0810852051): insert into jos_banners_delta values (14615,'2025-07-31 12:16:57','216.73.216.8','view'),(14202,'2025-07-31 12:16:57','216.73.216.8','view'),(14203,'2025-07-31 12:16:57','216.73.216.8','view')

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