We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




New Compounds to Benefit Kidney Disease Patients Unable to Undergo MRI Examinations

By MedImaging International staff writers
Posted on 29 Nov 2024
Image: A molecular trap for exotic metals promises improved diagnostics and faster drug development (Photo courtesy of Tomáš Belloň/IOCB Prague)
Image: A molecular trap for exotic metals promises improved diagnostics and faster drug development (Photo courtesy of Tomáš Belloň/IOCB Prague)

Lanthanides play a vital role in biomedical fields, including as contrast agents for magnetic resonance imaging (MRI) and in radiotherapeutics. However, enhancing their binding strength within pharmaceutical molecules has remained a challenge for the past 30 years. Stability is especially critical for gadolinium-based MRI contrast agents, as gadolinium can be harmful to the body if it leaks from the drug molecule. Researchers have now developed compounds that are up to a million times more stable than those used in current treatments for tumors or MRI contrast agents. These new compounds securely bind lanthanides within the molecules of medical drugs.

The breakthrough synthetic technique, called ‘ClickZip,’ was created by scientists from IOCB Prague (Prague, Czech Republic) and incorporates lanthanides into molecules in a nearly irreversible manner, enhancing their safety. According to the study published in Nature Communications, ClickZip operates as a ‘trap.’ The molecule starts in an open state, allowing the metal to enter a prepared binding site. Once the metal is in place, a chemical reaction triggers the ‘trap door’ to close, locking the metal in securely and preventing its release. These compounds could significantly benefit individuals with impaired kidney function who cannot safely undergo certain MRI scans, as their bodies excrete contrast agents slowly, raising the risk of gadolinium toxicity.

The applications of ClickZip extend beyond MRI. The compounds are so stable that they can withstand boiling in concentrated acid without breaking down. This stability allows researchers to tag molecules, such as peptide drugs, for testing in animal models. The tags enable precise tracking of how the drug distributes through tissues and in what quantities. This discovery opens up new possibilities not only in medicine but also in various industrial sectors. The scientists have patented the technology and are currently seeking a partner to help bring it to the market.

Related Links:
IOCB Prague

Gold Member
Electrode Solution and Skin Prep
Signaspray
Gold Member
Ultrasound System
FUTUS LE
Wireless Flat Panel Detector
ExamVue 10" x 12" Glassless Substrate Wireless
Mammography Diagnostic Station
Mammo Module

Radcal

Channels

Nuclear Medicine

view channel
Image: In vivo imaging of U-87 MG xenograft model with varying mass doses of 89Zr-labeled KLG-3 or isotype control (Photo courtesy of L Gajecki et al.; doi.org/10.2967/jnumed.124.268762)

Novel Radiolabeled Antibody Improves Diagnosis and Treatment of Solid Tumors

Interleukin-13 receptor α-2 (IL13Rα2) is a cell surface receptor commonly found in solid tumors such as glioblastoma, melanoma, and breast cancer. It is minimally expressed in normal tissues, making it... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.

Notice: The user specified as a definer ('admin'@'%') does not exist in /home/www/medsites/shared/includes/database.php on line 307

/home/www/medsites/shared/includes/post_processing.php:42
/home/www/medsites/shared/includes/post_processing.php:5
/home/www/medsites/medicalimaging/index.php:409168 queries executed
1
(98.943710327148): SET sql_mode = 'MYSQL40'
2 (!!!!! 3545.0458526611): SELECT folder, element, published, params FROM jos_mambots WHERE published >= 1 AND access <= 0 AND folder = 'system' ORDER BY ordering
3 (326.87187194824): SELECT template FROM jos_templates_menu WHERE client_id = 0 AND ( menuid = 0 OR menuid = 294803276 ) ORDER BY menuid DESC LIMIT 1
4 (315.18936157227): DELETE FROM jos_session WHERE time < 1750476176 AND guest = 1 AND userid = 0
5 (614.88151550293): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
6 (48.87580871582): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
7 (35.04753112793): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
8 (!!!!! 1873.0163574219): SELECT * FROM jos_menu WHERE id = 294803276
9 (880.95664978027): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
10 (!!!!! 1093.864440918): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
11 (799.89433288574): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
12 (!!!!! 1766.9200897217): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294803276) AND (fid=212) ORDER BY id DESC, `created` DESC LIMIT 0,16
13 (432.01446533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294803276) AND (fid=212) ORDER BY id DESC, `created` DESC LIMIT 0,16
14 (!!!!! 3989.9349212646): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=212 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294803276 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
15 (!!!!! 18501.996994019): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=212 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294803276 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
16 (!!!!! 7673.978805542): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294803276 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
17 (!!!!! 4006.8626403809): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294803276 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
18 (!!!!! 2331.9721221924): SELECT name,id,title FROM jos_deeppockets WHERE id=212 LIMIT 1
19 (74.148178100586): SELECT name,id,title FROM jos_deeppockets WHERE id=212 LIMIT 1
20 (670.9098815918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
21 (604.86793518066): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
22 (106.0962677002): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
23 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
24 (623.94142150879): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
25 (469.92301940918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
26 (94.890594482422): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
27 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
28 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
29 (90.122222900391): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
30 (!!!!! 1991.0335540771): SELECT conference_items.channel_id, conference_items.tracking_code FROM conference_items LEFT JOIN conference_groups ON conference_groups.id = conference_items.group_id LEFT JOIN jos_deeppockets ON jos_deeppockets.id = conference_items.channel_id LEFT JOIN jos_journal ON jos_journal.cat = jos_deeppockets.cat AND jos_journal.real = 1 AND jos_journal.directory IS NOT NULL WHERE 1 = 1 ORDER BY conference_items.id
31 (600.09956359863): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
32 (66.995620727539): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
33 (386.95335388184): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
34 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
35 (!!!!! 1923.7995147705): SELECT id, title, module, position, content, showtitle, params FROM jos_modules AS m INNER JOIN jos_modules_menu AS mm ON mm.moduleid = m.id WHERE m.published = 1 AND m.access <= 0 AND m.client_id != 1 AND ( mm.menuid = 0 OR mm.menuid = 294803276 ) ORDER BY ordering
36 (!!!!! 2274.9900817871): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
37 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
38 (!!!!! 11238.098144531): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 98 AND `site_id` = 10 AND `published` = 1
39 (!!!!! 9168.1480407715): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 99 AND `site_id` = 10 AND `published` = 1
40 (!!!!! 2438.0683898926): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
41 (137.0906829834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
42 (540.97175598145): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
43 (75.101852416992): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
44 (34.809112548828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
45 (611.0668182373): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
46 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
47 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
48 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
49 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
50 (623.22616577148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
51 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
52 (411.03363037109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
53 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
54 (859.02214050293): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
55 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
56 (328.77922058105): SELECT name FROM jos_deeppockets WHERE id=294803276 LIMIT 1
57 (352.14424133301): SELECT name FROM jos_deeppockets_archive WHERE id=294803276 LIMIT 1
58 (51.975250244141): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'
59 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
60 (460.86311340332): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
61 (!!!!! 1065.9694671631): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
62 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
63 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
64 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
65 (88.930130004883): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1
66 (509.97734069824): SELECT fid FROM jos_deeppockets WHERE id=294803276 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294803276 AND published='1' LIMIT 1
67 (313.99726867676): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`
68 (55.074691772461): select jos_twitters.link from jos_twitters where cat=10
69 (34.093856811523): select jos_facebook.link from jos_facebook where cat=10
70 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10
71 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10
72 (39.815902709961): SELECT fid FROM jos_deeppockets WHERE id=294803276 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294803276 AND published='1' LIMIT 1
73 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`
74 (277.04238891602): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803276 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
75 (226.02081298828): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803276 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
76 (43.869018554688): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
77 (72.956085205078): SELECT show_live FROM jos_com_show_setting LIMIT 1
78 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1
79 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1
80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1
81 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1
83 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
84 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1
85 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1
86 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
87 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1
88 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1
89 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1
90 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (56.028366088867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803276 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
92 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803276 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
93 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
94 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
105 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
106 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
107 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
108 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
109 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
110 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
113 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
114 (49.829483032227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
115 (421.04721069336): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
116 (557.18421936035): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
117 (349.04479980469): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
118 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
119 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
120 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
121 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
122 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
123 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
124 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
125 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
126 (298.97689819336): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
127 (!!!!! 20370.960235596): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
128 (493.04962158203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803276 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803276 AND type='deeppockets_item' AND published='1' LIMIT 1
129 (!!!!! 7897.8538513184): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
130 (77.009201049805): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
131 (361.20414733887): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
132 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
133 (32.186508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
134 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
135 (206.94732666016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
136 (33.140182495117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
137 (207.90100097656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
138 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
139 (616.07360839844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
140 (404.83474731445): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
141 (249.14741516113): SELECT name FROM jos_deeppockets WHERE id=212
142 (38.862228393555): SELECT name FROM jos_deeppockets WHERE id=212
143 (705.00373840332): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
144 (614.16625976562): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
145 (147.10426330566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
146 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
147 (!!!!! 9920.1202392578): TRUNCATE TABLE jos_trademed_module
148 (118.97087097168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
149 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803276 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
150 (!!!!! 1206.8748474121): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
151 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
152 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
153 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
154 (!!!!! 1551.1512756348): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
155 (427.0076751709): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
156 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
157 (262.02201843262): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803276 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803276 AND type='deeppockets_item' AND published='1' LIMIT 1
158 (691.89071655273): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
159 (53.882598876953): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
160 (58.889389038086): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
161 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
162 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803276 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803276 AND published='1' LIMIT 1
163 (159.97886657715): select jos_twitters.link from jos_twitters where cat=10
164 (37.908554077148): select jos_facebook.link from jos_facebook where cat=10
165 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10
166 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10
167 (357.15103149414): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
168 (!!!!! 1492.977142334): insert into jos_banners_delta values (14615,'2025-06-21 03:37:56','216.73.216.120','view'),(14202,'2025-06-21 03:37:56','216.73.216.120','view'),(14203,'2025-06-21 03:37:56','216.73.216.120','view')