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Biology-Driven Radiomics Approach to Identify Rectal Cancer Patients without Tumor Post Therapy

By MedImaging International staff writers
Posted on 25 Jun 2024

Image: The researchers will use AI to derive specific metrics from MRI scans to analyze the therapeutic response of rectal tumors more effectively (Photo courtesy of Shutterstock)

The American Cancer Society estimates that this year, around 46,000 people in the U.S. will be diagnosed with rectal cancer, which ranks as the third most common type of cancer in the digestive system, following colon and pancreatic cancers. For rectal cancer patients undergoing chemotherapy and radiation, clinicians often encounter challenges in determining which tumors are dying or significantly regressing post-therapy. Researchers are now planning to use artificial intelligence (AI) to improve the treatment of rectal cancer patients by accurately assessing their response to therapy, thus enabling personalized care through the selection of suitable candidates for non-operative management.

A research group, including experts from Case Western Reserve University (CWRU, Cleveland, OH, USA), has secured a five-year, USD 2.78 million grant from the National Institutes of Health and the National Cancer Institute to better personalize treatments for patients with rectal cancer. They plan to use AI to derive specific metrics from magnetic resonance imaging (MRI) scans to analyze the therapeutic response of rectal tumors more effectively. This investigation will utilize AI to examine medical images from over 900 patients with rectal cancer, applying a novel, biology-driven radiomics method, and will also incorporate data from a prior clinical trial involving patients with this disease.

The researchers will evaluate how effectively patients are responding to treatment using the insights obtained through this analysis. Their objective is to establish a non-invasive and precise technique for identifying patients who show no remaining tumor after therapy, thereby reducing unnecessary surgical interventions and their related complications. This research holds significant promise for identifying signs of tumor regression, exploring traits that typically remain undetected by human observation alone. Additionally, the team plans to integrate AI analysis with clinical assessments to develop ways to incorporate AI-derived insights into regular clinical practices.

“Our goal is to develop new types of radiomic signatures, involving computational analysis of radiology and pathology images, to determine how well these patients have responded to therapy,” said Satish Viswanath, an associate professor of biomedical engineering at Case Western Reserve and the grant’s lead researcher. “By doing so, doctors will be able to better personalize treatments for patients with rectal cancer.”

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64 (!!!!! 6613.01612854): select jos_twitters.link from jos_twitters where cat=10

65 (!!!!! 8216.1426544189): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 7724.0467071533): select jos_google_plus.link from jos_google_plus where cat=10

67 (!!!!! 8172.0352172852): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 7612.943649292): SELECT fid FROM jos_deeppockets WHERE id=294801646 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294801646 AND published='1' LIMIT 1

69 (!!!!! 8270.0252532959): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (!!!!! 3809.928894043): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 12125.968933105): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 7655.143737793): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 1981.0199737549): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (894.06967163086): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (!!!!! 1159.9063873291): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (360.96572875977): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (203.13262939453): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (612.02049255371): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (653.02848815918): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (505.92422485352): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (989.19868469238): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (226.97448730469): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (426.05400085449): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 1382.8277587891): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (!!!!! 2316.951751709): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (452.99530029297): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (162.12463378906): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (169.03877258301): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (560.99891662598): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (186.92016601562): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (183.10546875): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (153.0647277832): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (241.99485778809): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (146.86584472656): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (543.11752319336): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (169.99244689941): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1558.0654144287): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

105 (159.97886657715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

106 (396.9669342041): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (998.97384643555): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 6898.8800048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

109 (362.15782165527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

110 (182.15179443359): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (720.97778320312): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1307.0106506348): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (663.04206848145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1120.0904846191): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

115 (!!!!! 2522.9454040527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

116 (616.07360839844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

117 (174.99923706055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

118 (718.83201599121): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

119 (!!!!! 1390.9339904785): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

120 (874.04251098633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

121 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

122 (!!!!! 1380.9204101562): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 181602.00119019): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1302.0038604736): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801646 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801646 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 2315.9980773926): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (56.982040405273): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (75.101852416992): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (442.0280456543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (563.14468383789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (437.02125549316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (381.9465637207): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (59.127807617188): SELECT name FROM jos_deeppockets WHERE id=212

138 (29.087066650391): SELECT name FROM jos_deeppockets WHERE id=212

139 (614.88151550293): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (708.81843566895): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (95.844268798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

142 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

143 (!!!!! 22944.927215576): TRUNCATE TABLE jos_trademed_module

144 (379.08554077148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (95.129013061523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (497.81799316406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 2228.9752960205): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 2959.0129852295): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

149 (!!!!! 4696.1307525635): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

150 (!!!!! 1827.9552459717): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 8670.8068847656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

152 (!!!!! 4463.9110565186): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

153 (144.95849609375): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801646 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801646 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (!!!!! 3232.0022583008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (257.01522827148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (381.9465637207): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 6355.0472259521): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

158 (!!!!! 2620.9354400635): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801646 AND published='1' LIMIT 1

159 (118.01719665527): select jos_twitters.link from jos_twitters where cat=10

160 (51.021575927734): select jos_facebook.link from jos_facebook where cat=10

161 (44.822692871094): select jos_google_plus.link from jos_google_plus where cat=10

162 (40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10

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