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Non-Invasive Medical Imaging Test Predicts Dementia Nine Years before Diagnosis

By MedImaging International staff writers
Posted on 12 Jun 2024

Image: The first-of-its-kind test predicts dementia with over 80% accuracy and up to nine years before diagnosis (Photo courtesy of Queen Mary University of London)

Predicting future cases of dementia is crucial for developing interventions aimed at preventing the irreversible loss of brain cells responsible for dementia symptoms. While advancements have been made in identifying brain proteins linked to Alzheimer’s disease, many individuals carry these proteins for years without exhibiting dementia symptoms. Currently, dementia is commonly diagnosed through memory tests or by measuring brain shrinkage. Now, a newly developed method offers over 80% accuracy in predicting dementia up to nine years before an official diagnosis, providing a more precise approach to early identification.

Researchers at Queen Mary University of London (London, UK) developed this predictive test by analyzing functional MRI (fMRI) scans to assess changes in the brain’s ‘default mode network’ (DMN), which is essential for cognitive functions and is the first neural network impacted by Alzheimer’s disease. Utilizing fMRI scans from more than 1,100 volunteers from the UK Biobank—a comprehensive biomedical database containing health and genetic information from half a million UK participants—the team evaluated the effective connectivity among ten brain regions that make up the DMN. Each participant was assigned a probability of developing dementia based on how closely their connectivity patterns matched those typically seen in dementia versus control-like patterns.

The predictions were then matched against the medical records of the participants from the UK Biobank. Results demonstrated that the model could accurately forecast the onset of dementia up to nine years before it was officially diagnosed, with an accuracy rate exceeding 80%. For those who eventually developed dementia, the model was also able to predict, within a two-year margin of error, the timeline until diagnosis. Further investigations by the researchers explored whether alterations to the DMN could be attributed to known dementia risk factors. Their findings indicated that genetic predispositions to Alzheimer’s disease strongly correlated with connectivity changes in the DMN, reinforcing the notion that these alterations are specific to Alzheimer’s. Additionally, they noted that social isolation could increase dementia risk due to its impact on DMN connectivity.

“Using these analysis techniques with large datasets we can identify those at high dementia risk, and also learn which environmental risk factors pushed these people into a high-risk zone. Enormous potential exists to apply these methods to different brain networks and populations, to help us better understand the interplays between environment, neurobiology and illness, both in dementia and possibly other neurodegenerative diseases,” said Samuel Ereira, lead author and Academic Foundation Program Doctor at the Centre for Preventive Neurology, Wolfson Institute of Population Health. “fMRI is a non-invasive medical imaging tool, and it takes about 6 minutes to collect the necessary data on an MRI scanner, so it could be integrated into existing diagnostic pathways, particularly where MRI is already used.”

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63 (509.02366638184): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (256.06155395508): select jos_twitters.link from jos_twitters where cat=10

65 (264.88304138184): select jos_facebook.link from jos_facebook where cat=10

66 (48.87580871582): select jos_google_plus.link from jos_google_plus where cat=10

67 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

68 (349.04479980469): SELECT fid FROM jos_deeppockets WHERE id=294801509 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294801509 AND published='1' LIMIT 1

69 (48.87580871582): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (741.00494384766): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801509 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (585.79444885254): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801509 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (41.007995605469): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 1883.9836120605): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (161.88621520996): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (155.92575073242): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (367.16461181641): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (!!!!! 2671.9570159912): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (555.99212646484): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (299.93057250977): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801509 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (252.96211242676): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801509 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (105.85784912109): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 3447.0558166504): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (105.85784912109): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (866.17469787598): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (996.82807922363): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 7884.0255737305): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (!!!!! 4618.8831329346): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (!!!!! 3622.0550537109): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (!!!!! 7022.8576660156): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 8638.1435394287): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (!!!!! 7989.8834228516): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (!!!!! 7960.0811004639): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (!!!!! 5380.1536560059): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 1946.9261169434): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (112.05673217773): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 3695.9648132324): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

105 (!!!!! 8025.8846282959): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

106 (675.91667175293): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801509 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 1451.0154724121): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801509 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 3187.894821167): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

109 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

110 (336.88545227051): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801509 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 3108.024597168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801509 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1482.0098876953): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (825.16670227051): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1157.9990386963): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

115 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

116 (967.97943115234): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

117 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

118 (710.01052856445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

119 (260.1146697998): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

120 (795.84121704102): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

121 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

122 (!!!!! 2655.029296875): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 58388.948440552): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1111.0305786133): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801509 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801509 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (528.09715270996): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (218.86825561523): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (975.13198852539): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (63.180923461914): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (535.96496582031): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (576.01928710938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (59.843063354492): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (413.89465332031): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (249.86267089844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 6197.9293823242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (650.88272094727): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (425.81558227539): SELECT name FROM jos_deeppockets WHERE id=212

138 (54.121017456055): SELECT name FROM jos_deeppockets WHERE id=212

139 (914.8120880127): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (973.93989562988): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1353.0254364014): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

142 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

143 (!!!!! 23496.866226196): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 4131.0787200928): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801509 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (103.95050048828): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801509 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (848.05488586426): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (330.92498779297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (610.1131439209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

149 (!!!!! 3466.8445587158): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

150 (!!!!! 2735.8531951904): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 3416.0614013672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

152 (99.18212890625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

153 (319.9577331543): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801509 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801509 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (266.07513427734): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (124.93133544922): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (257.01522827148): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (802.99377441406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

158 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801509 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801509 AND published='1' LIMIT 1

159 (!!!!! 5158.9012145996): select jos_twitters.link from jos_twitters where cat=10

160 (492.81120300293): select jos_facebook.link from jos_facebook where cat=10

161 (56.028366088867): select jos_google_plus.link from jos_google_plus where cat=10

162 (41.007995605469): select jos_linkedin.link from jos_linkedin where cat=10

163 (735.04447937012): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1407.8617095947): insert into jos_banners_delta values (14615,'2025-08-02 03:00:51','216.73.216.210','view'),(14202,'2025-08-02 03:00:51','216.73.216.210','view'),(14203,'2025-08-02 03:00:51','216.73.216.210','view')

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