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Novel MRI Method Could Predict Early Response to Neoadjuvant Chemotherapy in Breast Cancer Patients

By MedImaging International staff writers
Posted on 18 Sep 2023

Image: A new MRI exam could predict chemotherapy’s effectiveness in breast cancer patients (Photo courtesy of 123RF)

Neoadjuvant chemotherapy is often administered to shrink tumors before surgery in patients with breast cancer. However, due to the varying mutations within the same genes in breast tumors, almost 80% of patients experience either partial or no response to traditional chemotherapy. The conventional way to evaluate a patient's reaction to chemotherapy is by monitoring changes in the size of the tumor, a process that can take between four and six months and multiple treatment cycles. Researchers are now examining if a new type of MRI can assess the effectiveness of a chemotherapy regimen for women with breast cancer based on just one round of treatment.

Magnetic Resonance Fingerprinting (MRF) is an innovative MRI method that can examine multiple tissues in the body with a single, time-saving image or "fingerprint." This advanced technology has the potential for a wide range of clinical uses, including early disease identification and gauging how well a treatment is working. Researchers at Case Western Reserve University (Cleveland, OH, USA) are studying whether MRF can provide an early indication of how well neoadjuvant chemotherapy is working in breast cancer patients.

If MRF can deliver consistent insights into the effectiveness of neoadjuvant chemotherapy in breast cancer patients, it could help patients avoid treatments that are not required and enable physicians to explore other options more quickly. Early findings from their research suggest that MRF can accurately evaluate the effectiveness of therapy between seven and ten days after the first cycle of chemotherapy. This could greatly enhance patient care, offering the chance for more individualized treatment plans for many women.

“This study has great potential to bring real survival and quality-of-life benefits to our breast cancer patients,” said Yong Chen, an assistant professor of radiology at the Case Western Reserve School of Medicine. “The ultimate goal is to eliminate ineffective treatments in eligible subjects and instead tailor the treatment methods for optimum therapeutic outcomes for women with breast cancer.”

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71 (!!!!! 1059.0553283691): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (908.13636779785): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 1137.9718780518): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (385.04600524902): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (310.89782714844): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (704.05006408691): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (246.04797363281): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (821.11358642578): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (319.00405883789): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (701.904296875): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (682.83081054688): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (504.0168762207): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (91.075897216797): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (267.02880859375): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (149.96528625488): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (221.96769714355): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (630.85556030273): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (197.8874206543): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (154.01840209961): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (128.03077697754): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (!!!!! 1781.9404602051): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (211.00044250488): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (474.92980957031): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (304.9373626709): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (791.07284545898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

105 (!!!!! 1029.9682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

106 (629.90188598633): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798652 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 1701.831817627): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798652 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1064.0621185303): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

109 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

110 (333.07075500488): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798652 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 3197.9084014893): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798652 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (611.0668182373): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (352.14424133301): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

115 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

116 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

117 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

118 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

119 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

120 (288.00964355469): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 137329.1015625): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (!!!!! 7980.1082611084): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

123 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

124 (450.84953308105): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798652 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798652 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 865982.05566406): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (200.98686218262): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (214.0998840332): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (174.04556274414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (229.1202545166): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (186.92016601562): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (236.98806762695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (205.99365234375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (!!!!! 1420.0210571289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (!!!!! 2918.9586639404): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (161.88621520996): SELECT name FROM jos_deeppockets WHERE id=212

136 (51.975250244141): SELECT name FROM jos_deeppockets WHERE id=212

137 (854.9690246582): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (679.01611328125): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

140 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

141 (!!!!! 12608.051300049): TRUNCATE TABLE jos_trademed_module

142 (!!!!! 5472.8984832764): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798652 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (193.83430480957): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798652 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (774.86038208008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (313.04359436035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

147 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

148 (!!!!! 1245.0218200684): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (128.03077697754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

150 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

151 (393.15223693848): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798652 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798652 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (190.01960754395): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (177.86026000977): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

154 (380.9928894043): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (158.07151794434): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

156 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798652 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798652 AND published='1' LIMIT 1

157 (80.108642578125): select jos_twitters.link from jos_twitters where cat=10

158 (67.949295043945): select jos_facebook.link from jos_facebook where cat=10

159 (81.062316894531): select jos_google_plus.link from jos_google_plus where cat=10

160 (70.095062255859): select jos_linkedin.link from jos_linkedin where cat=10

161 (353.09791564941): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 11197.090148926): insert into jos_banners_delta values (14615,'2025-04-30 05:22:08','3.144.46.149','view'),(14202,'2025-04-30 05:22:08','3.144.46.149','view'),(14203,'2025-04-30 05:22:08','3.144.46.149','view')

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