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New Scanning Method Combines Two MRI Techniques to Detect Deadly Heart Condition Before Symptoms Appear

By MedImaging International staff writers
Posted on 20 Jul 2023

Image: New scanning methods can detect deadly hypertrophic cardiomyopathy ahead of symptoms (Photo courtesy of UCL)

Hypertrophic cardiomyopathy (HCM) is a genetic disorder characterized by thicker than normal heart muscle walls, affecting the heart's ability to pump blood efficiently. HCM is a primary cause of heart failure and sudden cardiac death. A new study has revealed that a combination of two types of heart scan techniques could enable medical professionals to detect HCM earlier than current conventional tests allow. This early detection of HCM could also support trials exploring gene therapies and medications aimed at preventing the disease's development in high-risk individuals.

In collaborative research involving investigators from University College London (UCL, London, UK), the team analyzed the hearts of three groups: healthy individuals, patients already diagnosed with HCM, and people with an HCM-inducing genetic mutation but no observable signs of the disease (no heart muscle thickening). The team employed two advanced heart scanning techniques: cardiac diffusion tensor imaging (cDTI), a type of MRI scan that reveals how individual heart muscle cells are organized and packed together (the heart's microstructure), and cardiac MRI perfusion (perfusion CMR), which identifies problems with small blood vessels supplying the heart muscle (microvascular disease).

The scans revealed that individuals with overt HCM symptoms exhibit severely disorganized heart muscle cells and a high incidence and severity of microvascular disease compared to healthy participants. Importantly, the scans were also capable of detecting abnormal microstructure (muscle cell disorganization) and microvascular disease in those carrying the problematic gene yet without any symptoms or muscle thickening. The researchers found that 28% of these individuals had blood supply defects compared to healthy volunteers. This enabled doctors to more accurately identify early HCM signs developing in patients' hearts.

Mavacamten - the first medication to slow HCM progression - recently received approval in Europe, allowing doctors to mitigate the disease's severity once symptoms and muscle thickening become apparent. In addition, genetic therapies are being developed that could potentially prevent symptoms altogether by intercepting HCM at an early stage. Perfusion CMR is already employed in some clinics to distinguish HCM patients from other causes of muscle thickening. The researchers believe that these groundbreaking therapies, combined with cDTI and perfusion CMR scans, offer doctors the best opportunity yet to treat high-risk HCM individuals early enough to prevent the disease's development.

“The ability to detect early signs of HCM could be crucial in trials testing treatments aimed at preventing early disease from progressing or correcting genetic mutations. The scans could also enable treatment to start earlier than we previously thought possible,” said Dr. George Joy from the UCL Institute of Cardiovascular Science who led the research. “We now want to see if we can use the scans to identify which patients without symptoms or heart muscle thickening are most at risk of developing severe HCM and its life-changing complications. The information provided from scans could therefore help doctors make better decisions on how best to care for each patient.”

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68 (36.001205444336): SELECT fid FROM jos_deeppockets WHERE id=294797966 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294797966 AND published='1' LIMIT 1

69 (36.954879760742): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (371.93298339844): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797966 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (234.84230041504): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797966 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (69.856643676758): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (42.915344238281): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797966 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.994415283203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797966 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (125.88500976562): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

105 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

106 (82.015991210938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294797966 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294797966 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

109 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

110 (74.863433837891): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294797966 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (547.17063903809): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294797966 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (679.96978759766): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (513.07678222656): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (125.88500976562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

115 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

116 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

117 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

118 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

119 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

120 (329.97131347656): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 29145.956039429): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

123 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

124 (439.16702270508): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797966 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797966 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 467622.99537659): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (134.94491577148): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (610.1131439209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (395.05958557129): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (206.23207092285): SELECT name FROM jos_deeppockets WHERE id=212

136 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=212

137 (427.0076751709): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (344.99168395996): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

140 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

141 (!!!!! 8894.9203491211): TRUNCATE TABLE jos_trademed_module

142 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294797966 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (53.167343139648): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294797966 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (853.06167602539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

147 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

148 (!!!!! 1125.0972747803): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

150 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

151 (55.074691772461): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797966 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797966 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (37.908554077148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

154 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (109.19570922852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

156 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797966 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797966 AND published='1' LIMIT 1

157 (56.982040405273): select jos_twitters.link from jos_twitters where cat=10

158 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

159 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

160 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

161 (339.98489379883): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1271.9631195068): insert into jos_banners_delta values (14615,'2025-04-30 04:39:56','18.222.178.70','view'),(14202,'2025-04-30 04:39:56','18.222.178.70','view'),(14203,'2025-04-30 04:39:56','18.222.178.70','view')

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